Navigation Links
Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
Date:2/14/2008

New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics.

The protein called mesothelin appears to play an important role in promoting pancreatic cancer growth, said the senior author Dr. Qizhi (Cathy) Yao, professor of surgery vascular surgery at BCM. She, along with co-lead authors Dr. Min Li, assistant professor of surgery, and research associate Dr. Uddalak Bharadwaj carried out the studies of the protein that is found on the tumor cells surface.

Mesothelin is found in other cancers for several years, said Yao, also a researcher in the Dan L. Duncan Cancer Center at BCM. However, we didnt know the role it played in pancreatic cancer: until she and her colleagues reported in this article. In fact, they found very high levels of mesothelin in 18 of 21 samples of patients pancreatic tissues compared to amounts found in nearby normal tissues. In studies of this protein in the lab, pancreatic cancer cell lines that produced high levels of mesothelin grew faster and spread more than those in which mesothelin levels were lower.

Pancreatic cancer cells grew and spread faster in mice whose tumors expressed high levels of mesothelin than in those whose cancer did not, said the researchers, who conducted the studies in an immune deficient mouse.

We saw this molecule as very significant in the life of the tumor cells, Yao said. Our next step is to identify whether this would be a good active immunotherapy target.

Making a treatment vaccine of virus-like particles (VLPs) that contained mesothelin, researchers injected mice having pancreatic cancer with this vaccine three times. Virus-like particles have the unique property of inducing protective immune responses but they lack the infectious capacities of
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. MIT works toward engineered blood vessels
2. Engineered weathering process could mitigate global warming
3. Genetically engineered corn may harm stream ecosystems
4. Study shows genetically engineered corn could affect aquatic ecosystems
5. Engineered eggshells to help make hydrogen fuel
6. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
7. A step toward tissue-engineered heart structures for children
8. Tiny dust particles from Asian deserts common over western United States
9. MIT sculpts 3-D particles with light
10. MIT: Remote-control nanoparticles deliver drugs directly into tumors
11. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... but deadly disease that exists as five strains, none ... lethal strains is the Sudan ebolavirus (SUDV). Although not ... widespread illness, even as recently as 2012. In a ... Biology , researchers now report a possible therapy that ... John Dye, Sachdev Sidhu, Jonathan Lai and colleagues explain ...
(Date:8/27/2014)... lost or abandoned each year in U.S. waters and ... to catch fish, crabs, and other species such as ... and the watermen who depend on the resources--losses that ... study. , The report, published in the Marine ... to examine the derelict fish trap problem, and so-called ...
(Date:8/27/2014)... shown that piglets can be weaned later with no ... of the study at the University,s Roseworthy campus, published ... an important finding for pig producers. It allows improvements ... , "Sows don,t usually start their oestrous cycles again ... have been weaned," says Ms Alice Weaver, PhD candidate ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2
... , New Rochelle, NY, June 24, 2011Basal insulin ... treatment of type 2 diabetes, enabling patients to ... reducing hypoglycemic episodes. These revolutionary, long-acting basal insulin ... in diabetes, and infusion pumps that provide subcutaneous, ...
... years ago, a tiny mayfly had a problem. Like most adult ... was no time to waste. She took her mating flight, got fertilized, ... She got stuck in some oozing tree sap and died, preserved for ... It was a pretty rude ending to what was already going ...
... Astronomers, research on celestial bodies may have an ... astronomers are working with medical physicists and radiation oncologists ... that is intended to be tougher on tumors, but ... elements emit and absorb radiation inside stars and around ...
Cached Biology News:Safer and more effective diabetes control with basal insulin analogs 2Ancient species of mayfly had short, tragic life 2Astronomers reach for the stars to discover new cancer therapy 2Astronomers reach for the stars to discover new cancer therapy 3Astronomers reach for the stars to discover new cancer therapy 4
(Date:8/27/2014)... 2014 Budding Biomedical Scientists , ... School participated in the Scientific Enrichment and ... School of Medicine . , The ... professional experience in the sciences and brings them ... and students for both academic and career mentoring. ...
(Date:8/26/2014)... 2014 The 20 ambassadors representing the ... community issued the following statement on Facebook today regarding ... driving new funding specifically for ALS research: , “Who ... some ice would raise all this awareness and funding ... and on behalf of the entire ALS community, would ...
(Date:8/26/2014)...  ViveBio, LLC a leading provider of products ... announced today that it has signed a distribution ... Knoxville, Tennessee to distribute ... United States . ViveST is the first ... biological specimen transport systems.  The technology enables easy, ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 Genedata, ... drug discovery and life science research, today announced ... will be held in Asia, Europe, and ... global pharmaceutical companies and leading research organizations will ... best practices, case studies, and upcoming challenges in ...
Breaking Biology Technology:Students at Cleveland's University School Conduct Biomedical Research at Case Western Reserve University’s School of Medicine 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3
... Madison, Wis. - Stratatech Corp. has received ... Institute on Aging , a division of the National ... gene therapy products for the use in the treatment of ... stasis and pressure ulcers. , ,It is estimated that in ...
... Brookfield, Wis.-based Fiserv, Inc. and CUNA ... delivery and presentation of CUNA Mutual's payment ... with the technology solutions offered by Fiserv ... CUNA Mutual's payment protection products, which include credit life, ...
... Wis. -- We take it for granted the lights ... and ice storms can temporarily bring down power lines and ... of us believe affordable power will always be there - ... ,If only it was as easy as flipping a switch. ...
Cached Biology Technology:Keeping Wisconsin supplied with energy won't get any easier 2Keeping Wisconsin supplied with energy won't get any easier 3
... Have you bought a Perkin Elmer UltraVIEW system ... the Andor iXon and iQ software? No problem. ... upgrade. You keep your existing microscope, lasers, Sutter ... customise it to work with our precision controller ...
...
... is a 96-well ELISA-compatible plate (containing 12 x ... Monoclonal Antibody is immobilized by a method that ... the tail fiber protein of the T7 bacteriophage. ... 10 9 phage per well and low ...
... The TRAPeze RT Telomerase Detection ... in vitro assay for the ... quantification of telomerase activity. It ... TRAPeze assay and adds the ...
Biology Products: