Navigation Links
Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
Date:2/14/2008

New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics.

The protein called mesothelin appears to play an important role in promoting pancreatic cancer growth, said the senior author Dr. Qizhi (Cathy) Yao, professor of surgery vascular surgery at BCM. She, along with co-lead authors Dr. Min Li, assistant professor of surgery, and research associate Dr. Uddalak Bharadwaj carried out the studies of the protein that is found on the tumor cells surface.

Mesothelin is found in other cancers for several years, said Yao, also a researcher in the Dan L. Duncan Cancer Center at BCM. However, we didnt know the role it played in pancreatic cancer: until she and her colleagues reported in this article. In fact, they found very high levels of mesothelin in 18 of 21 samples of patients pancreatic tissues compared to amounts found in nearby normal tissues. In studies of this protein in the lab, pancreatic cancer cell lines that produced high levels of mesothelin grew faster and spread more than those in which mesothelin levels were lower.

Pancreatic cancer cells grew and spread faster in mice whose tumors expressed high levels of mesothelin than in those whose cancer did not, said the researchers, who conducted the studies in an immune deficient mouse.

We saw this molecule as very significant in the life of the tumor cells, Yao said. Our next step is to identify whether this would be a good active immunotherapy target.

Making a treatment vaccine of virus-like particles (VLPs) that contained mesothelin, researchers injected mice having pancreatic cancer with this vaccine three times. Virus-like particles have the unique property of inducing protective immune responses but they lack the infectious capacities of the original virus.

Tumor growth in the immunized mice slowed and in some cases the tumor disappeared. The average life span for the mice not treated was four weeks. The immunized mice survived five weeks longer than those not treated.

Researchers found that the immunization works by suppressing production of key immune system cells that suppress the bodys ability to fight the tumor. The researchers said pancreatic cancers produce these cells, called T regulatory cells, as a protective measure.

If we are able to see the same results in humans, this would allow us to incorporate a combination therapy to treat the tumor, Yao said. Treatment with a single drug is not effective.

Yao and her colleagues are seeking U.S. Food and Drug Administration approval to begin studies using their vaccination on people suffering from pancreatic cancer.


'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. MIT works toward engineered blood vessels
2. Engineered weathering process could mitigate global warming
3. Genetically engineered corn may harm stream ecosystems
4. Study shows genetically engineered corn could affect aquatic ecosystems
5. Engineered eggshells to help make hydrogen fuel
6. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
7. A step toward tissue-engineered heart structures for children
8. Tiny dust particles from Asian deserts common over western United States
9. MIT sculpts 3-D particles with light
10. MIT: Remote-control nanoparticles deliver drugs directly into tumors
11. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... News solutions for biometrics, bag drop and New ADA-compliant kiosk ... At PTE 2017 ... Materna will present its complete end-to-end passenger journey, from ... benefit for passengers. To accelerate the whole passenger handling process, ... to take passengers through the complete integrated process with a ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader of ... elite iris biometric solution on the latest Qualcomm® ... at Mobile World Congress 2017 (February 27 ... in Hall 3, Stand 3E10. ... Haven™ security platform—a combination of hardware, software ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a community ... that it has received Laboratory Accreditation from the ... is presented to laboratories that meet stringent requirements ... scientifically rigorous processes. "Genos is committed ... laboratory practices. We,re honored to be receiving CAP ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... -- GlobeImmune, Inc. today announced it has entered into a ... of its common stock to NantCell, Inc., a member ... sale of its common stock, NantCell has agreed to ... 200,000 shares, an estimated $2.0 million in value, of ... to enter into this strategic agreement with NantCell," said ...
(Date:3/23/2017)... 23, 2017 Kineta, Inc., a biotechnology ... therapies in immuno-oncology, today announced the discovery and ... compounds that activate interferon response factor 3 (IRF3) ... immune-mediated tumor regression in a murine colon carcinoma ... demonstrated complete tumor regression to initial drug treatment ...
(Date:3/23/2017)... GREENWOOD VILLAGE, Colo. , March 23, 2017 /PRNewswire/ ... million in Series A financing and note conversion to ... products. Cool Planet is focused on developing products that ... raised nearly $30 million in the last 18 months. ... Coppel and North Bridge Venture Partners. ...
(Date:3/22/2017)... March 22, 2017 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), ... Center (RGC), U.K. Biobank and GSK to generate genetic sequence ... resource. The initiative will enable researchers to gain valuable insights ... a wide range of serious and life threatening diseases. ... Genetic evidence ...
Breaking Biology Technology: