Navigation Links
Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer
Date:2/14/2008

New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics.

The protein called mesothelin appears to play an important role in promoting pancreatic cancer growth, said the senior author Dr. Qizhi (Cathy) Yao, professor of surgery vascular surgery at BCM. She, along with co-lead authors Dr. Min Li, assistant professor of surgery, and research associate Dr. Uddalak Bharadwaj carried out the studies of the protein that is found on the tumor cells surface.

Mesothelin is found in other cancers for several years, said Yao, also a researcher in the Dan L. Duncan Cancer Center at BCM. However, we didnt know the role it played in pancreatic cancer: until she and her colleagues reported in this article. In fact, they found very high levels of mesothelin in 18 of 21 samples of patients pancreatic tissues compared to amounts found in nearby normal tissues. In studies of this protein in the lab, pancreatic cancer cell lines that produced high levels of mesothelin grew faster and spread more than those in which mesothelin levels were lower.

Pancreatic cancer cells grew and spread faster in mice whose tumors expressed high levels of mesothelin than in those whose cancer did not, said the researchers, who conducted the studies in an immune deficient mouse.

We saw this molecule as very significant in the life of the tumor cells, Yao said. Our next step is to identify whether this would be a good active immunotherapy target.

Making a treatment vaccine of virus-like particles (VLPs) that contained mesothelin, researchers injected mice having pancreatic cancer with this vaccine three times. Virus-like particles have the unique property of inducing protective immune responses but they lack the infectious capacities of
'/>"/>

Contact: Graciela Gutierrez
ggutierr@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. MIT works toward engineered blood vessels
2. Engineered weathering process could mitigate global warming
3. Genetically engineered corn may harm stream ecosystems
4. Study shows genetically engineered corn could affect aquatic ecosystems
5. Engineered eggshells to help make hydrogen fuel
6. Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials
7. A step toward tissue-engineered heart structures for children
8. Tiny dust particles from Asian deserts common over western United States
9. MIT sculpts 3-D particles with light
10. MIT: Remote-control nanoparticles deliver drugs directly into tumors
11. Worldwide atmospheric measurements will determine the role of atmospheric fine particles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... October 1, 2014 Novel ... life science field  The life science ... go over the years. Some are shooting stars ... is a novel detection technology that has raised ... finally, this technology is becoming commercially available. With ...
(Date:9/30/2014)... something that we enjoy when we visit a national park ... of ourselves as a part of nature? A bird,s nest ... , The answers to these questions reflect different cultural ... and in cultural artifacts. , A new Northwestern University study, ... Center of Chicago and the Menominee tribe of Wisconsin, focuses ...
(Date:9/30/2014)... and Howard Hughes Medical Institute investigator, and Margarita ... in the 2014 round of grants from the ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative for ... 30, provides more than $3 million in funding ... The BRAIN Initiative, launched last year, is a ...
Breaking Biology News(10 mins):First-of-a-kind Solution for Utilizing Photon Upconversion 2The cultural side of science communication 2Salk scientists receive $3 million for BRAIN Initiative grant 2
... than a dozen countries joined together to sequence the tomato ... The Tomato Genomics Consortium directed the research effort, which ... Foundation and the USDA,s Agriculture Research Services. The OU ... Emeritus in the College of Arts and Sciences, was one ...
... 2012) -- A detailed analysis of more than 4 ... help electricity producers slash as much as 30 percent ... dioxide from power plant emissions. The research by ... Lawrence Berkeley National Laboratory (LBNL) and the Electric Power ...
... Madrid, May, 31st, 2012.- Madrid will become ... during the Biomedical Innovation Conference 2012, focused on ... Madrid-MIT M+Vision Consortium. This new organization has been ... and the regional Government of the Comunidad de ...
Cached Biology News:New materials could slash energy costs for CO2 capture 2New materials could slash energy costs for CO2 capture 3MADRID-MIT M+Vision Consortium hosts Biomedical Innovation Conference 2012 2
(Date:10/1/2014)... 2014 Today the National Institutes ... grants for the Brain Research through Advancing Innovative ... develop and revolutionize new methods of understanding the ... brain. This first round of grants totaling $46 ... allocated to more than 100 investigators in 15 ...
(Date:10/1/2014)... TeselaGen Biotechnology has received ... expand their bioCAD/CAM software suite, which uses synthetic ... Small Business Innovation Research Phase II grant will be ... license from the Lawrence Berkeley National Laboratory. j5 was ... LBNL laboratory that develops alternative fuel technologies for the ...
(Date:9/30/2014)... 2014 Applying a well-known optical phenomenon called ... University has demonstrated the ability to "paint" ultra-thin ... holds promise for making future, flexible electronic devices, ... of next-gen rocket ships and spacecraft with extremely ... oil in water, it becomes iridescent, revealing a ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released the DSES-1000 ... tool for measuring displacement in rubber and other ... movement distance, the DSES-1000 can measure elongations up ... 10 mm. In addition, it achieves +/- 0.2 ... within +/- 100 µm below 50-mm stroke. , ...
Breaking Biology Technology:NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Taking thin films to the extreme 2Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2
... announced that Ricky Takai, Ph.D., has joined the company ... the firm, Dr. Takai will become the leader of ... Takai brings his more than 20 years experience in ... the field of education to the company.Most recently, Dr. ...
... Inc. (Nasdaq: BMRN ) today announced ... placebo-controlled clinical study of 6R-BH4 in patients with ... no statistical significance observed between the 6R-BH4 treatment ... peak walking time (PWT), did not show a ...
... CHICAGO, Feb. 3 Advanced Life Sciences Holdings,Inc. (Nasdaq: ... the discovery,development and commercialization of novel drugs in the ... that the Company,will make a corporate presentation to investors ... Company,s presentation will be delivered in the Windsor Suite,at ...
Cached Biology Technology:Dr. Ricky Takai, Expert in Designing and Managing Federal Evaluation Studies in Education, Joins Abt Associates 2Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 2Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 3Results From Phase 2 Clinical Study of 6R-BH4 in Peripheral Arterial Disease Not Statistically Significant 4Advanced Life Sciences to Present at the 11th Annual BIO CEO & Investor Conference 2Advanced Life Sciences to Present at the 11th Annual BIO CEO & Investor Conference 3
... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ... 11.25 6.40 in. Mfr ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
...
...
Biology Products: