Navigation Links
Mesenchymal stem cell transplantation may heal a mother's childbirth injury
Date:9/17/2013

Putnam Valley, NY. (Sept. 17 2013) Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence" (SUI), a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective.

Seeking better methods to alleviate SUI, researchers carried out a study in which female laboratory rats modeled with simulated childbirth injuries received injections of mesenchymal stem cells (MSCs; multipotent cells found in connective tissues that can differentiate into a variety of cell types including: bone, cartilage and fat cells) to see if the cells would home to and help to repair the damaged pelvic organs.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-cog_09636897_ct0957dissaranan.

"Stem cell-based therapy has recently gained attention as a promising treatment for SUI," said study co-author Dr. Margot S. Damaser of the Cleveland Clinic's Department of Biomedical Engineering. "Stem cell therapies may be more feasible and less invasive than current therapies."

The current study extended the results of the researcher's previous studies by demonstrating that the transplanted MSCs homed to the animals' spleens. This suggested that the transplanted cells could have a beneficial impact when they released trophic factors, agents that stimulate differentiation and survival of cells and then engrafted into the smooth muscle of the urethra and vagina, as demonstrated previously in prior studies.

"Our results suggest a potential therapy for postpartum SUI," said Dr. Damaser.

The group of female rats that received simulated childbirth injury (vaginal distension) and MSCs showed homing of the MSCs to the urethra and vagina, facilitating the recovery of continence.

The researchers noted that other kinds of stem cells from different sources have been used in other studies aimed at treating SUI via stem cell transplantation. Autologous (self-donated) muscle-derived stem cells have demonstrated therapeutic potential for SUI in animal models and in clinical trials. Adipose (fat)-derived stem cells have also been used to improve urethral function after simulated childbirth injury in rats.

This study used MSCs, cells which are believed to be "immune-privileged," with no rejection issues. The advantage in this, said the researchers, is that MSCs may have potential as an "off-the-shelf" therapy.

"Since rat MSCs were used in this study, the results can only be applied to rat models of injury-treated rats," explained Dr. Damaser. "Human adult stem cells need to be investigated in future studies to see if these findings also apply to humans."

The researchers suggested that their work also has potential to develop into a therapy for older women with SUI at a time "remote from delivery."

"This study provides evidence that mesenchymal stem cell transplantation could favorably impact a side effect of delivery and aging by releasing factors that can influence the urethra and vagina to treat stress urinary incontinence" said Dr Amit N. Patel, director of cardiovascular regenerative medicine at the University of Utah and section editor for Cell Transplantation. "Further studies are required to confirm that this animal study translates to humans."


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
2. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
3. Some factors that impact islet transplantation explored in Cell Transplantation papers
4. Some factors that impact islet transplantation explored in Cell Transplantation papers
5. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
6. New studies show spinal cord injury and ALS respond to cell transplantation
7. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
8. Neurons made from stem cells drive brain activity after transplantation in laboratory model
9. Cell Transplantation reports islet cell advancement increases impact on transplantation
10. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
11. Impact of stem cell transplantation location in brain a crucial factor for cell survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric Face ... ... DERMALOGs Face Matching enables to match face pictures against ... basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching ...
(Date:3/9/2017)... FRANCISCO and MOUNTAIN VIEW, Calif. ... , "Eating Well Made Simple," and 23andMe , ... help guide better food choices.  Zipongo can now provide ... their food preferences, health goals and biometrics, but also ... certain food choices. Zipongo,s personalized food decision ...
Breaking Biology News(10 mins):
(Date:3/22/2017)...   iSpecimen ®, the marketplace for ... Service (DPS), a full-service anatomic pathology reference lab ... States , has joined a program offered by ... (DHIN) to make human biospecimens and associated data available ... announced in 2015 as a collaboration between iSpecimen and ...
(Date:3/22/2017)... 22, 2017 MarketNewsUpdates.com News Commentary  ... The traditional ... being pressured as of late due to the rise of ... has a dramatic impact on patient,s quality of life as ... for identifying new forms of opioid formulations that prevent abuse. ...
(Date:3/22/2017)... Mass. , March 22, 2017   Boston ... next-generation cancer therapeutics designed to target cancer stemness pathways, ... Patricia S. Andrews as Chief Executive Officer, effective ... succeed Chiang J. Li , M.D., FACP, who ... ten years ago. Under his leadership, Boston Biomedical has ...
(Date:3/22/2017)... ... March 21, 2017 , ... Premier executive recruitment firm, Slone Partners, is ... by Hunt Scanlon Media. , Hunt Scanlon Media is one of the ... global news source in the human capital sector. , “It is a great honor ...
Breaking Biology Technology: