Navigation Links
Mesenchymal stem cell transplantation may heal a mother's childbirth injury
Date:9/17/2013

Putnam Valley, NY. (Sept. 17 2013) Vaginal delivery presents the possibility of injury for mothers that can lead to "stress urinary incontinence" (SUI), a condition affecting from four to 35 percent of women who have had babies via vaginal delivery. Many current treatments, such as physiotherapy and surgery, are not very effective.

Seeking better methods to alleviate SUI, researchers carried out a study in which female laboratory rats modeled with simulated childbirth injuries received injections of mesenchymal stem cells (MSCs; multipotent cells found in connective tissues that can differentiate into a variety of cell types including: bone, cartilage and fat cells) to see if the cells would home to and help to repair the damaged pelvic organs.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-cog_09636897_ct0957dissaranan.

"Stem cell-based therapy has recently gained attention as a promising treatment for SUI," said study co-author Dr. Margot S. Damaser of the Cleveland Clinic's Department of Biomedical Engineering. "Stem cell therapies may be more feasible and less invasive than current therapies."

The current study extended the results of the researcher's previous studies by demonstrating that the transplanted MSCs homed to the animals' spleens. This suggested that the transplanted cells could have a beneficial impact when they released trophic factors, agents that stimulate differentiation and survival of cells and then engrafted into the smooth muscle of the urethra and vagina, as demonstrated previously in prior studies.

"Our results suggest a potential therapy for postpartum SUI," said Dr. Damaser.

The group of female rats that received simulated childbirth injury
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
2. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
3. Some factors that impact islet transplantation explored in Cell Transplantation papers
4. Some factors that impact islet transplantation explored in Cell Transplantation papers
5. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
6. New studies show spinal cord injury and ALS respond to cell transplantation
7. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
8. Neurons made from stem cells drive brain activity after transplantation in laboratory model
9. Cell Transplantation reports islet cell advancement increases impact on transplantation
10. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
11. Impact of stem cell transplantation location in brain a crucial factor for cell survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... --- Do we think of nature as something that we ... need to "preserve?" Or do we think of ourselves as ... of nature, but what about a house? , The ... also reflected in our actions, our speech and in cultural ... the University of Washington, the American Indian Center of Chicago ...
(Date:9/30/2014)... do seedless watermelon, salmon, and strawberries all have in ... two sets of chromosomes and are diploid, these organisms ... sets of chromosomesseedless watermelon and salmon have 3 and ... While this might seem surprising, in fact most ... first discovered over a century ago, but only recently, ...
(Date:9/30/2014)... The National Institutes of Health (NIH) awarded ... to develop an electrode array system that will ... works through unprecedented resolution and scale. , LLNL,s ... support President Obama,s BRAIN (Brain Research through ... effort to revolutionize our understanding of the human ...
Breaking Biology News(10 mins):The cultural side of science communication 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4NIH taps lab to develop sophisticated electrode array system to monitor brain act 2NIH taps lab to develop sophisticated electrode array system to monitor brain act 3
... having a child and attending university may be subconsciously influenced ... a Queen,s University study. "Life expectancy might be driving ... doctoral fellow in the Queen,s math department who has a ... to live, the more time they will invest in education. ...
... drink blood and spread disease such as river blindnesscreating misery ... that the pesky insects can be useful. Don Champagne, ... Environmental Sciences, discovered a way to use the black fly,s ... were published in the journal PLoS One . ...
... nanoparticles to convert laser energy into "plasmonic nanobubbles," researchers ... Cancer Center and Baylor College of Medicine (BCM) are ... directly into cancer cells. In tests on drug-resistant cancer ... nanobubbles was up to 30 times more deadly to ...
Cached Biology News:Black flies may have a purpose after all 2Black flies may have a purpose after all 3'Nanobubbles' plus chemotherapy equals single-cell cancer targeting 2'Nanobubbles' plus chemotherapy equals single-cell cancer targeting 3'Nanobubbles' plus chemotherapy equals single-cell cancer targeting 4
(Date:9/30/2014)... Hungary , September 30, 2014 ... and intuitive browsing of chemistry in documents ... chemistry software solutions and consulting services for life ... chemical information and generate Markush structures from documents. ... an organizations intellectual property, however generating and understanding ...
(Date:9/30/2014)... 30, 2014 OriginOil Inc. (OTC/QB: OOIL), ... process to clean up large quantities of water, announced ... Eckelberry reported on the launch of the company's CLEAN-FRAC™ ... provided by partner STW Resources . , Immediately ... per day (bpd) and achieved a 99.8% reduction in ...
(Date:9/30/2014)... 30, 2014 BioHealth Innovation, Inc. ... biohealth innovations and increasing access to early-stage funding in ... venture capitalist, Tania Fernandez , Ph.D., has joined ... will be a member of the management team for ... to $50 million in seed and early-stage equity investments ...
(Date:9/30/2014)... iLab Solutions announced the results of its ... focuses on core facility operations, growth and utilization as ... , In its 4th year running, a number of ... year-over-year decrease in the percentage of revenue that comes ... the constraints of this trend. When asked, “What are ...
Breaking Biology Technology:ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3
... RainDance Technologies, Inc., a privately held provider ... disease research, today announced it will be shipping ... and reviewed the company,s opportunities for growth at ... initial application of the company,s RainStorm(TM) microdroplet-based technology ...
... and CEO of Cryo-Cell International and C,elle(SM), Welcomes President ... As the CEO of Cryo-Cell International, the nation,s most ... been an active participant in the stem cell and ... the changes that have taken place over the past ...
... Biotech, an Advanced Instruments company, will introduce its ... which delivers faster cycle times, a touch screen ... and efficiency in microbiology laboratories -- at The ... May, 2009."The introduction of the new Autoplate represents ...
Cached Biology Technology:RainDance Technologies Reviews Opportunities for Growth at Cowen Health Care Conference 2RainDance Technologies Reviews Opportunities for Growth at Cowen Health Care Conference 3Stem Cell Industry Insider Mercedes Walton Discusses President Obama's Stem Cell Executive Order 2Stem Cell Industry Insider Mercedes Walton Discusses President Obama's Stem Cell Executive Order 3Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 2Spiral Biotech to Introduce New Autoplate Spiral Plating System at ASM General Meeting in May 3
Rabbit polyclonal to LCAT ( Abpromise for all tested applications). entrezGeneID: 3931 SwissProtID: P04180...
Mouse monoclonal [7E10] to C Peptide ( Abpromise for all tested applications). entrezGeneID: 3630 SwissProtID: P01308...
... transporter 2 (APT2) (Peptide ... PSF2) (Peptide supply factor ... involved in antigen processing ... Antigen: Recombinant ...
This monoclonal antibody recognizes the light chain of human Factor XII and at 100 nM inhibits 50% of Factor XII activity. It may be used in ELISA to detect human Factor XII and in coagulation assay...
Biology Products: