Navigation Links
Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk. That is the conclusion of a study at Fox Chase Cancer Center exploring how families communicate genetic test results.

Like their female relatives, fathers, sons or brothers can also harbor a mutation in the BRCA 1 or 2 genes. Male carriers of these mutations, more commonly called the breast cancer genes, face a 14 percent lifetime risk of developing prostate cancer as well as a 6 percent lifetime risk of developing breast cancer

Despite these health implications, we have found a lack of understanding of genetic test results among men in these families, said Mary B. Daly, M.D., Ph.D., senior vice president for population science at Fox Chase and lead author of the new research presented at the San Antonio Breast Cancer Symposium today.

Daly and her colleagues interviewed 24 men, each with a first-degree female relative who tested positive for having a BRCA1 or BRCA2 mutation. The women reported telling the results of their genetic test result to the male relative in the study, though only 18 of the men remember receiving the results.

Daly said what they learned demonstrates a level of cognitive and emotional distance that men experience from the genetic testing process.

Nearly half of the men (seven) who remembered receiving results did not believe that the test results increased their own risk of cancer. Only five (28 percent) could correctly identify their chance of being a mutation carrier.

We devote a significant amount of time learning how best to communicate genetic test results to women, but this study shows we also need to help them communicate the information to their male family members who may be impacted by the test results, concluded Daly.

Fourteen of the 18 men who recalled receiving the results expressed some level of concern about the meaning of the test result, but most (11) directed their concern toward other family members, primarily daughters and sisters.

Based on the responses, we were not surprised to learn that the level of interest in genetic testing was relatively low. Of the six men who did express interest, half said theyd do it for their childrens sake.


Contact: Karen Mallet
Fox Chase Cancer Center

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Elephantnose fish see with their chin
3. Flies can turn off their immune response
4. UCR plant cell biologist to study how plant stem cells maintain and change their identity
5. Species still have more viable offspring if they can choose their best mate
6. Spatial patterns in tropical forests can help to understand their high biodiversity
7. Clever plants chat over their own network
8. Saltwater crocodiles can find their way home
9. Doctors learn to control their own brains pain responses to better treat patients
10. Sea cucumbers fast track organ regrowth by healing their wounds
11. Scientists uncover how hormones achieve their effects
Post Your Comments:
(Date:11/4/2015)... , November 4, 2015 ... market report published by Transparency Market Research "Home Security Solutions ... and Forecast 2015 - 2022", the global home security solutions ... bn by 2022. The market is estimated to expand ... from 2015 to 2022. Rising security needs among customers ...
(Date:10/29/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that it has ... as one of only three finalists for a ... and Growing" category. The Tekne Awards honor Minnesota ... technology innovation and leadership. iMedNet™ eClinical ...
(Date:10/29/2015)... Va. , Oct. 29, 2015 Daon, ... today that it has released a new version of ... customers in North America have ... IdentityX v4.0 also includes a FIDO UAF certified ... are already preparing to activate FIDO features. These customers ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris ... that its business and prospects remain fundamentally strong ... Zoptrex™ (zoptarelin doxorubicin) recently received DSMB recommendation to ... completion following review of the final interim efficacy ... 2 Primary Endpoint in men with heavily pretreated ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
(Date:11/24/2015)... ... 24, 2015 , ... The United States Golf Association (USGA) today announced Dr. ... Award. Presented annually since 1961, the USGA Green Section Award recognizes an individual’s distinguished ... , Clarke, of Iselin, N.J., is an extension specialist of turfgrass pathology in ...
(Date:11/24/2015)... VANCOUVER , Nov. 24, 2015 /CNW/ - iCo ... ICOTF), today reported financial results for the quarter ... are expressed in Canadian dollars and presented under ... the United States ," said Andrew ... "These advancements regarding iCo-008 are not only value ...
Breaking Biology Technology: