Navigation Links
Men unaware of their cancer risk when female relatives test positive for BRCA mutation

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk. That is the conclusion of a study at Fox Chase Cancer Center exploring how families communicate genetic test results.

Like their female relatives, fathers, sons or brothers can also harbor a mutation in the BRCA 1 or 2 genes. Male carriers of these mutations, more commonly called the breast cancer genes, face a 14 percent lifetime risk of developing prostate cancer as well as a 6 percent lifetime risk of developing breast cancer

Despite these health implications, we have found a lack of understanding of genetic test results among men in these families, said Mary B. Daly, M.D., Ph.D., senior vice president for population science at Fox Chase and lead author of the new research presented at the San Antonio Breast Cancer Symposium today.

Daly and her colleagues interviewed 24 men, each with a first-degree female relative who tested positive for having a BRCA1 or BRCA2 mutation. The women reported telling the results of their genetic test result to the male relative in the study, though only 18 of the men remember receiving the results.

Daly said what they learned demonstrates a level of cognitive and emotional distance that men experience from the genetic testing process.

Nearly half of the men (seven) who remembered receiving results did not believe that the test results increased their own risk of cancer. Only five (28 percent) could correctly identify their chance of being a mutation carrier.

We devote a significant amount of time learning how best to communicate genetic test results to women, but this study shows we also need to help them communicate the information to their male family members who may be impacted by the test results, concluded Daly.

Fourteen of the 18 men who recalled receiving the results expressed some level of concern about the meaning of the test result, but most (11) directed their concern toward other family members, primarily daughters and sisters.

Based on the responses, we were not surprised to learn that the level of interest in genetic testing was relatively low. Of the six men who did express interest, half said theyd do it for their childrens sake.


Contact: Karen Mallet
Fox Chase Cancer Center

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Elephantnose fish see with their chin
3. Flies can turn off their immune response
4. UCR plant cell biologist to study how plant stem cells maintain and change their identity
5. Species still have more viable offspring if they can choose their best mate
6. Spatial patterns in tropical forests can help to understand their high biodiversity
7. Clever plants chat over their own network
8. Saltwater crocodiles can find their way home
9. Doctors learn to control their own brains pain responses to better treat patients
10. Sea cucumbers fast track organ regrowth by healing their wounds
11. Scientists uncover how hormones achieve their effects
Post Your Comments:
(Date:11/26/2015)... Research and Markets ( ) has ... - Technology and Patent Infringement Risk Analysis" report ... --> Fingerprint sensors using capacitive technology represent ... sensor vendor Idex forecasts an increase of 360% of ... and of the fingerprint sensor market between 2014 and ...
(Date:11/18/2015)... York , November 18, 2015 ... Research has published a new market report titled  Gesture ... Trends, and Forecast, 2015 - 2021. According to the report, ... 2014 and is anticipated to reach US$29.1 bn by ... 2021. North America dominated ...
(Date:11/16/2015)... Calif. , Nov 16, 2015  Synaptics ... of human interface solutions, today announced expansion of ... TouchView ™ touch controller and display driver ... revolution of smartphones. These new TDDI products add ... TD4100 (HD resolution), TD4302 (WQHD resolution), and TD4322 ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... N.Y. , Nov. 30, 2015  Culprits ... by assistant chemistry professor Jan Halámek, is taking ...   --> ...   --> ... at UAlbany have discovered a straightforward concept for ...
(Date:11/30/2015)... Md. , Nov. 30, 2015 ... development company committed to the fostering and monetization ... the current and prospective initiatives designed to create ... Chief Executive Officer of Spherix. "Based on published ... future licensees exceeds $50 billion and Spherix will ...
(Date:11/30/2015)... DIEGO , Nov. 30, 2015 Human ... that the company has acquired Cypher Genomics, Inc., a ... robust human genomic interpretation software solutions. The ... will join HLI including Cypher CEO and Co-founder, Ashley ... of HLI,s Pediatric Business.  Financial details of the deal ...
(Date:11/30/2015)... Nov. 30, 2015  Aytu BioScience, Inc. (OTCQB: AYTU), ... related conditions, will present at two upcoming investor conferences. ... interactive real-time virtual conference, to be held December 3, ... to be held December 2 nd & 3 ... and streamed live via webcast. Josh ...
Breaking Biology Technology: