Navigation Links
Men and women are different in terms of genetic predispositions
Date:9/20/2012

We are not all the same when it comes to illness. In fact, the risk of developing a disease such as diabetes or heart disease varies from one individual to another. A study led by Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty of Medicine of the University of Geneva (UNIGE) reveals that the genetic predisposition to develop certain diseases may differ from one individual to another depending on their sex. Together with his collaborators, the professor has shown that genetic variants have a different impact on the level of gene expression between men and women. The results of this research have been published in the scientific journal Genome Research.

For decades geneticists have been interested in genetic variants that affect the level of gene expression. These variants spark the interest of researchers because they play a role in the predisposition to certain diseases. Professor Dermitzakis' team from UNIGE, in collaboration with Oxford University, focused on the fundamental differences in the genetics of gene expression between men and women. After analyzing the impact of genetic variants on the level of gene expression in women, and then in men, the scientists have found that the effect of certain variants affecting gene expression and the genetic risk of developing a disease resulting from these genetic variants is different depending on the sex of the individual.

Everyone will agree that men and women are different but, beyond the obvious, genetics brings to light more subtle differences. The researchers found that even with the same DNA mutation in men and in women, the impact on the level of gene expression will be different. Of all the genetic variants that have an impact on the level of gene expression, about 15% work differently depending on whether they are acting upon a man or a woman.

We already knew that certain environmental factors like diet had a variable impact depending on the sex of an individual. Today, we are able to confirm that genetic variants have a different impact on the level of gene expression in men and women; that is to say that although two individuals of opposite sex both have a same variant predisposing them to a disease, they will not have the same propensity to develop it, states Professor Dermitzakis.


'/>"/>

Contact: Emmanouil Dermitzakis
emmanouil.dermitzakis@unige.ch
41-223-795-483
Universit de Genve
Source:Eurekalert

Related biology news :

1. 2 servings of salmon a week is healthy for pregnant women and their babies
2. American Society of Plant Biologists honors early career women scientists
3. Supplement use predicts folate status in Canadian women
4. Knee injuries in women linked to motion, nervous system differences
5. Women & Infants participating in study of treatment of common viral infection in pregnancy
6. Vitamin D for pregnant women and babies -- how much is enough?
7. Breast cancer in young women: A distinct disease
8. Womens scientific achievements often overlooked and undervalued
9. Brain circuitry is different for women with anorexia and obesity
10. Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa
11. UCSB anthropologists finds high levels of omega-3 fatty acids in breast milk of Amerindian women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
(Date:3/21/2016)... 22, 2016 Unique technology ... for superior security   Xura, ... of secure digital communications services, today announced it is ... offer enterprise customers, particularly those in the Financial Services ... voice authentication within a mobile app, alongside, and in ...
Breaking Biology News(10 mins):
(Date:5/5/2016)... ... May 05, 2016 , ... American ... two additional patents, U.S. Patent Nos. 9,322,133 and 9,322,134, to API and its ... nanocellulose as well as hydrophobic nanocellulose compositions. In addition to these patents ...
(Date:5/5/2016)... ... May 05, 2016 , ... ProMIS Neurosciences (“ProMIS” ... first three targets, it has identified a fourth in a series of novel ... development and progression of Alzheimer’s disease (AD). , “This discovery is ...
(Date:5/4/2016)... ... May 04, 2016 , ... Looking for ... San Diego’s premiere hands-on cooking experience. Offering everything from gourmet cooking classes to ... she won’t forget. , Guests that visit LaJollaCooks4u share an experience unlike any ...
(Date:5/4/2016)... May 4, 2016  Bayer today announced that ... Stivarga ® (regorafenib) tablets for the treatment ... met its primary endpoint of a statistically significant ... evaluated the efficacy and safety of regorafenib in ... treatment with sorafenib. The safety and tolerability were ...
Breaking Biology Technology: