Navigation Links
Memory machine
Date:8/16/2007

What happens in our brains when we learn and remember" Are memories recorded in a stable physical change, like writing an inscription permanently on a clay tablet" Prof. Yadin Dudai, Head of the Weizmann Institutes Neurobiology Department, and his colleagues are challenging that view. They recently discovered that the process of storing long-term memories is much more dynamic, involving a miniature molecular machine that must run constantly to keep memories going. They also found that jamming the machine briefly can erase long-term memories. Their findings, which appeared today in the journal Science, may pave the way to future treatments for memory problems.

Dudai and research student Reut Shema, together with Todd Sacktor of the SUNY Downstate Medical Center, trained rats to avoid certain tastes. They then injected a drug to block a specific protein into the taste cortex an area of the brain associated with taste memory. They hypothesized, on the basis of earlier research by Sacktor, that this protein, an enzyme called PKMzeta, acts as a miniature memory machine that keeps memory up and running. An enzyme causes structural and functional changes in other proteins: PKMzeta, located in the synapses the functional contact points between nerve cells changes some facets of the structure of synaptic contacts. It must be persistently active, however, to maintain this change, which is brought about by learning. Silencing PKMzeta, reasoned the scientists, should reverse the change in the synapse. And this is exactly what happened: Regardless of the taste the rats were trained to avoid, they forget their learned aversion after a single application of the drug.

The technique worked as successfully a month after the memories were formed (in terms of life span, more or less analogous to years in humans) and all signs so far indicate that the affected unpleasant memories of the taste had indeed disappeared. This is the first time that memories in the brain
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers Uncover Key Step In Manufacture of Memory Protein
2. Nanogen Issued Patent for Electronic Microarray With Memory
3. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
4. Structure-building cell signals also may influence learning and memory
5. Mice brains shrink during winter, impairing some learning and memory
6. Montreal researchers probe the genetic basis of memory
7. New research shows why too much memory may be a bad thing
8. U of MN researchers reverse memory loss in mice
9. Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. Tracking the memory trace
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new implementation of ... enable rapid and secure transactions and reliable identification ... is a turnkey solution providing mouse and keyboard ... integrate fingerprint ID solutions into their product offerings, ...
(Date:3/2/2015)... 2, 2015   Neurotechnology , a provider of ... SentiGaze Software Development Kit (SDK). The SentiGaze ... use off-the-shelf webcams to track eye movements and generate ... monitor. Heatmaps can be used for applications such as ... advertising. The SDK can also be used to develop ...
(Date:2/24/2015)... YORK , Feb. 24, 2015 This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11
... classified as overweight are less likely to die over a ten ... according to a new study published today in the Journal ... taken over a decade among more than 9,200 Australian men and ... study, who were assessed for their health and lifestyle as part ...
... As so-called primary producers, plants use solar energy to ... process of photosynthesis works in much the same way as ... these, plant leaves must cope with variations in the level ... and his colleagues at LMU Munich have been studying how ...
... Disease Control and Prevention, the U.S. Food and Drug Administration ... Service are investigating a multistate outbreak of Salmonella Montevideo. ... Iowa confirmed on Monday, Jan. 25, that this strain of ... people in 39 states (one case in Iowa) since July ...
Cached Biology News:'Overweight' adults age 70 or older are less likely to die over a 10-year period 2Green energy management 2Green energy management 3Hygienic Lab at U. Iowa first to confirm salmonella in nationwide outbreak 2
(Date:3/26/2015)... the popular news television program that airs in numerous markets ... actor James Earl Jones, has announced that it will address ... Botany is commonly described as the scientific study of plants, ... complicated than that. Scientists and other professionals study a wide ... bacteria known to man to the largest trees that grow ...
(Date:3/25/2015)... Russia,s pharmaceutical market is one of the ... to its absolute size, plus a growing economy and ... from Business Monitor International. The Russian market is set ... pharmaceutical market, with growth estimates around 10-15% annually reaching ... About Green Cross Green Cross ...
(Date:3/25/2015)... , March 25, 2015 Optimal Research, LLC ... Industry Excellence (ViE) Award "Best Clinical Site or Trial ... that Optimal has been selected as a nominee in ... receiving a "Highly Recommended" distinction in 2014. The ViE ... the efforts, accomplishments, and positive contributions of companies and ...
(Date:3/25/2015)... 2015 Laboratory workers can turn ... Analytical Balances to get best-performing features while still ... balances from the trusted brand include: , ... your efficiency by providing a large weighing surface ... modes include parts counting, percent weighing, checkweighing, animal/dynamic ...
Breaking Biology Technology:Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
... TORAYMYXIN™ IN SEPTIC SHOCK ... ... --> ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r in ...
... Oct. 19 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc. (OTC Bulletin ... a fast-growing, profitable developer, manufacturer and seller of medicine ... announced today that its wholly owned subsidiary, En Ze ... the State Intellectual Property Office of the People,s Republic ...
... The US and European medical technology industry struggled ... but managed to improve overall net income by nearly ... While medtech has fared better than many industries in ... strain on the industry,s long-standing business model. These and ...
Cached Biology Technology:SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 2SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 3SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 4SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 5SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 6SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 7SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 8SPECTRAL INITIATES U.S. PIVOTAL TRIAL OF TORAYMYXIN™ IN SEPTIC SHOCK 9Lotus Pharmaceuticals Announces New Patent for Controlled-Release Diabetes Drug 2Lotus Pharmaceuticals Announces New Patent for Controlled-Release Diabetes Drug 3Medtech Industry Successfully Weathering Challenges of Economic Downturn 2Medtech Industry Successfully Weathering Challenges of Economic Downturn 3Medtech Industry Successfully Weathering Challenges of Economic Downturn 4Medtech Industry Successfully Weathering Challenges of Economic Downturn 5
... NEW VSOS-4P, all Programmable and Digital Orbital Shaker. ... been redesigned to make every day use even ... memory for up to 4 different programs. Its ... your program. Furthermore, the VSOS-4P has a pulse ...
... Fixed clamp trays ... easy Magnetic drive ... rpm 25 mm amplitude ... 25 ml to 2000 ml, including ...
... System is a fluorescent microscopy-based imaging system ... cells and automatically calculates cell viability, in ... routine function, the variability associated with the ... eliminated. Using the EasyCount ViaSure Kit, up ...
... 2-3x faster than western blotting. Get results ... Direct on gel detection. Eliminates the need ... detection methods. All reagents are ready-to-use. No ... to use. Only 2 reagents required. Guarantees a ...
Biology Products: