Navigation Links
Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms
Date:8/31/2014

This news release is available in French.

Montral, August 31, 2014 A study just published in the prestigious Nature Neuroscience journal by, Sylvain Williams, PhD, and his team, of the Research Centre of the Douglas Mental Health University Institute and McGill University, opens the door towards better understanding of the neural circuitry and dynamic mechanisms controlling memory as well of the role of an essential element of the hippocampus a sub-region named the subiculum.

In 2009, they developed a unique approach namely, the in vitro preparation of a hippocampal formation. Now, the research team of Dr. Williams has succeeded in demonstrating in mice that, contrary to what has been thought to be the case for a hundred years, the flow of activity linked to memory in the hippocampus is not unidirectional and that the subiculum is not simply the exit point of this flow.

At the heart of memory

Memories form the very core of our identity. Despite this, the creation and retrieval of memories are phenomena that are not yet well understood. The neural circuitry underlying learning and memory are studied primarily because of their fundamental role in memory and diseases affecting it, such as Alzheimer's. The work of Dr. Williams and his team in the last few years has been concerned with understanding the dynamics of this circuitry. While we can say that the processes of memory encoding and retrieval require the activation of hundreds of thousands of neurons in the hippocampus working together synchronously, we still know very little about the circuits or "routes" underlying these processes.

Understanding how neurons of the hippocampus behave will give powerful insights into the anomalies in neural circuitry involved in Alzheimer's disease and schizophrenia and will lead to more targeted interventions.

"It is only by identifying these circuits as well as their dynamic within the hippocampus that we will understand the mechanisms responsible for memory," says Dr. Williams. "Moreover, a better comprehension of the intricate dynamics of these circuits could be used to identify very early changes indicating the development, or future development, of Alzheimer's disease. Indeed, we have recent results that show that, in mouse models of Alzheimer's, these small alterations can appear long before memory loss."

This recent research was able to be undertaken thanks to optogenetics, a revolutionary technique which offers the unique capability to manipulate specific groups of neurons with light to better understand their role in neural circuits and brain rhythms.

The complete article (Reversal of theta rhythm flow through intact hippocampal circuits) is published on August 31in Nature Neuroscience.


'/>"/>

Contact: Florence Meney
florence.meney@douglas.mcgill.ca
Douglas Mental Health University Institute
Source:Eurekalert

Related biology news :

1. A gene linked to disease found to play a critical role in normal memory development
2. Selective verbal memory impairment due to left fornical crus injury after IVH
3. UC Davis memory researcher wins Pentagon grant
4. A protein couple controls flow of information into the brains memory center
5. Experiments prove stemness of individual immune memory cells
6. Studying estrogens made by the brain may offer new insights in learning and memory
7. Transplantation of new brain cells reverses memory loss in Alzheimers disease model
8. Substance P in hippocampus versus striatal marginal division for learning/memory function
9. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
10. Rescue of Alzheimers memory deficit achieved by reducing excessive inhibition
11. Immune response affects sleep and memory -- new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer and ... they have entered into a multiyear collaboration to identify and characterize novel CRISPR-Cas ... tools for gene editing across all applications. , Under the terms of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... genomics analysis platform specifically designed for life science researchers to analyze and ... researcher Rosalind Franklin, who made a major contribution to the discovery of ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
Breaking Biology Technology: