Navigation Links
Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms
Date:8/31/2014

This news release is available in French.

Montral, August 31, 2014 A study just published in the prestigious Nature Neuroscience journal by, Sylvain Williams, PhD, and his team, of the Research Centre of the Douglas Mental Health University Institute and McGill University, opens the door towards better understanding of the neural circuitry and dynamic mechanisms controlling memory as well of the role of an essential element of the hippocampus a sub-region named the subiculum.

In 2009, they developed a unique approach namely, the in vitro preparation of a hippocampal formation. Now, the research team of Dr. Williams has succeeded in demonstrating in mice that, contrary to what has been thought to be the case for a hundred years, the flow of activity linked to memory in the hippocampus is not unidirectional and that the subiculum is not simply the exit point of this flow.

At the heart of memory

Memories form the very core of our identity. Despite this, the creation and retrieval of memories are phenomena that are not yet well understood. The neural circuitry underlying learning and memory are studied primarily because of their fundamental role in memory and diseases affecting it, such as Alzheimer's. The work of Dr. Williams and his team in the last few years has been concerned with understanding the dynamics of this circuitry. While we can say that the processes of memory encoding and retrieval require the activation of hundreds of thousands of neurons in the hippocampus working together synchronously, we still know very little about the circuits or "routes" underlying these processes.

Understanding how neurons of the hippocampus behave will give powerful insights into the anomalies in neural circuitry involved in Alzheimer's disease and schizophrenia and will lead to more targeted interventions.

"It is only by identifying these circuits as well as their dynamic within the hippocampus that we will understand the mechanisms responsible for memory," says Dr. Williams. "Moreover, a better comprehension of the intricate dynamics of these circuits could be used to identify very early changes indicating the development, or future development, of Alzheimer's disease. Indeed, we have recent results that show that, in mouse models of Alzheimer's, these small alterations can appear long before memory loss."

This recent research was able to be undertaken thanks to optogenetics, a revolutionary technique which offers the unique capability to manipulate specific groups of neurons with light to better understand their role in neural circuits and brain rhythms.

The complete article (Reversal of theta rhythm flow through intact hippocampal circuits) is published on August 31in Nature Neuroscience.


'/>"/>

Contact: Florence Meney
florence.meney@douglas.mcgill.ca
Douglas Mental Health University Institute
Source:Eurekalert

Related biology news :

1. A gene linked to disease found to play a critical role in normal memory development
2. Selective verbal memory impairment due to left fornical crus injury after IVH
3. UC Davis memory researcher wins Pentagon grant
4. A protein couple controls flow of information into the brains memory center
5. Experiments prove stemness of individual immune memory cells
6. Studying estrogens made by the brain may offer new insights in learning and memory
7. Transplantation of new brain cells reverses memory loss in Alzheimers disease model
8. Substance P in hippocampus versus striatal marginal division for learning/memory function
9. Portable brain-mapping device allows UT Arlington researchers to see where memory fails
10. Rescue of Alzheimers memory deficit achieved by reducing excessive inhibition
11. Immune response affects sleep and memory -- new study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... 2017 , ... Dr. Asher Kimchi, Founder and Chairman of the International ... at the 22nd World Congress on Heart Disease held in Vancouver, BC, Canada. In ... Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. John A. Elefteriades ...
(Date:7/20/2017)... and PLYMOUTH, Minn., July 20, 2017 /PRNewswire/ ... , a personalized genetic evaluations company, today announced ... their partnership investigating a genetic mutation implicated in ... extend the partnership for a second case involving ... year, the KCNQ2 Cure Alliance and Pairnomix entered ...
(Date:7/18/2017)... ... , ... Sourcing custom glass or quartz parts can be a daunting task. ... execute your job can take many hours of emails, phone calls and on-line research. ... showcase the company’s capabilities and core custom categories, and enables you to start the ...
(Date:7/18/2017)... ... July 18, 2017 , ... Allotrope Foundation won the 2017 ... of the Allotrope Framework for commercial use. , The Bio-IT World Best Practices ... elevate the critical role of information technology in modern biomedical research, but also ...
Breaking Biology Technology: