Navigation Links
Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
Date:7/22/2013

Putnam Valley, NY. -- When melatonin, a hormone secreted by the pineal gland, was used as a pre-treatment for mesenchymal stem cells (MSCs) prior to their transplantation into the brains of laboratory animals to repair damage from stroke, researchers in China found that the stem cells survived longer after transplantation. Previous studies had shown that 80 percent of transplanted MSCs died within 72 hours of transplantation. By contrast, the melatonin pre-treatment "greatly increased" cell survival, said the researchers.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0998tang

The pineal gland is a small endocrine gland located in the center of the brain, but outside of the bloodbrain barrier. The melatonin it secretes acts as a signal and forms part of the system that regulates the sleepwake cycle by chemically causing drowsiness and lowering body temperature. Melatonin is also known to be a powerful antioxidant and has been used clinically to treat sleep disorders.

In this study, the researchers used a melatonin pre-treatment on MSCs they harvested from the laboratory animals that had been chemically modeled with ischemic brain injury (stroke). Previous studies had shown that MSCs "express" melatonin receptors M1 and M2.

"Mesenchymal cells can be harvested from self-donors (autologous) without ethical concerns," said study co-author Dr. Guo-Yuan Yang of the Neuroscience and Neuroengineering Research Center at the Shanghai Jiao Tong University in Shanghai, China. "Studies have shown that MSCs differentiate into various cells and can, upon transplantation, improve functional recovery after ischemic brain injury. In this study we used laboratory rats chemically modeled with stroke and tried to determine if pretre
'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
2. Pitt team finds melatonin delays ALS symptom onset and death in mice
3. Environmental factors in Tiny Tims near fatal illness
4. Soy-based S-equol supplement reduces metabolic syndrome risk factors
5. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
6. Impaired recovery of Atlantic cod -- forage fish or other factors?
7. Longer sleep times may counteract genetic factors related to weight gain
8. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
9. Time, place and how wood is used are factors in carbon emissions from deforestation
10. SRI Sarnoffs Iris on the Move® N-Glance™ Identification System Receives Lenel Factory Certification
11. Growth factor in stem cells may spur recovery from MS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... 11, 2014 The increased risk of kidney injury ... resuscitation fluids reflects the mass of HES molecules, according ... official journal of the International Anesthesia Research Society (IARS). ... harmful effect of HES on cultured human renal proximal ... Christian Wunder and colleagues of University Hospital Wrzburg, Austria. ...
(Date:7/11/2014)... , July 11, 2014 Research ... "International Biometrics Technology Market - Industry Analysis Size ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... and crimes has created a need for high level ... used for personnel authentication such as username and passwords, ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... When students using the Ask a Biologist Web site ask ... actually accessing the combined knowledge of more than 150 volunteer ... "That,s why Dr. Biology is so amazing," says Charles Kazilek, ... on the planet." Kazilek,s site, which attracts 3,000-4,000 visitors ...
... for the Advancement of Science has chosen Arizona State ... science education, to receive the Science Prize ... The prize, established to "encourage innovation and excellence in ... resources by students, teachers, and the public," recognizes the ...
... fish species in the ocean, but the majestic gliding ... astonishing feat of mathematics and energy conservation. In new ... Functional Ecology marine scientists reveal how these ... buoyancy and stay afloat. For most animals movement ...
Cached Biology News:Science selects 'Ask a Biologist' website to win SPORE award 2Science selects 'Ask a Biologist' website to win SPORE award 3Science selects 'Ask a Biologist' website to win SPORE award 4ASU’s Ask A Biologist website wins prestigious SPORE prize 2ASU’s Ask A Biologist website wins prestigious SPORE prize 3Whale sharks do the math to avoid that sinking feeling 2
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... 2014   Ceres, Inc . (Nasdaq: ... today financial results for the three months ended May ... Ceres reported that the company and its ... growing season in Brazil, which concluded in June, despite ... evaluation areas for part of the growing season. Yields ...
(Date:7/10/2014)... the journal PNAS (Proceedings of the National Academy ... and sleep deprivation have a significant effect on our ... the best time of day to test for diseases ... medicines effectively. , Researchers from the University of Surrey ... links between sleep deprivation, body clock disruption and metabolism, ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2
... drug discovery and development company eMetagen Corp . ... Marquette University Golden Angels Network , the angel investors ... Golden Angels investment, along with two grants received last ... the National Institutes of Health and a $150,000 Technology ...
... in any foreign land now requires a quick custom check. ... true nationality? What's this nation doing on the global scene ... Do I really like this nation? , ,It's no secret ... savvy than they were a decade ago. They clearly support ...
... - Ann Stunden, director of the Division of ... received a 2005 award for information technology leadership from ... honored Stunden for "strong and ground-breaking leadership in the ... 37 years ago." , ,A co-founder and executive ...
Cached Biology Technology:eMetagen gets $535,000 from MU angel investors 2Why are brands culturally profiled? 2Why are brands culturally profiled? 3
Anti-TNKS2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: ELISA, Western Blot...
Rabbit Anti-Human Janus Kinase 2 (JAK2 Polyclonal Antibody Family: Protein Kinase Sub-Family: TYK2/JAK Applications: ELISA, Western Blot...
Goat polyclonal to Lipocalin 2...
Human GCP-2 is a member of the CXC family of chemokines. It also promotes neutrophil chemotaxis and deganulation. GF063 is an 8.0 kDa protein containing 73 amino acid residues....
Biology Products: