The studycoordinated by University of Granada lecturer Ahmad Agilshowed that chronic administration of melatonin sensitizes the thermogenic effect of exposure to cold, heightens the thermogenic effect of exercise and, therefore, constitutes excellent therapy against obesity. The fact is that one of the key differences between 'beige fat', which appears when administering melatonin, and 'white fat', is that 'beige fat' cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.
The studyauthored by Aroa Jimnez-Aranda, Gumersindo Fernndez-Vzquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agilhas been part-financed and supported by the Granada Research of Excellence Initiative on BioHealth (GREIB), the University of Granada Vice-Rectorate for Scientific Policy and Research, and the regional government of Andalusia research group CTS-109.
Given the importance of this discovery, the researchers are confident they will obtain the funding needed to continue their worksays principle researcher Ahmad Agil"and be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes".
|Contact: Ahmad Agil|
University of Granada