Navigation Links
Melatonin helps control weight gain as it stimulates the appearance of 'beige fat'

Melatonin is a natural hormone segregated by the body and melatonin levels generally increase in the dark at night. It is also found in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries.

Spanish scientists have discovered that melatonin consumption helps control weight gain because it stimulates the appearance of 'beige fat', a type of fat cell that burns calories in vivo instead of storing them. White adipose tissue stores calories leading to weight gain whereas 'beige fat' (also known as 'good or thinning fat') helps regulate body weight control, hence its metabolic benefits.

In the Journal of Pineal Research, scientists from the University of Granada Institute for Neuroscience, the Hospital Carlos III, Madrid, and the University of Texas Health Science Center in San Antonio (USA) have revealed, for the first time, the previously unknown enigma of why melatonin has metabolic benefits in treating diabetes and hyperlipidemia.

In earlier publications, the researchers analysed the effects of melatonin on obesity, dyslipidemia, high blood pressure and type 2 diabetes mellitus associated with obesity in young obese diabetic Zucker ratsan experimental model of metabolic syndrome.

In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of 'beige fat' in obese diabetic rats, but also increases its presence in thin animals used as a control group. 'Beige fat' cells are found in scattered lentil-sized deposits beneath the inguinal skin in obese diabetic Zucker rats.

Melatonin is a natural hormone segregated by the human body itself and melatonin levels generally increase in the dark at night. It is also found in small quantities in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries. These findings, together with the pharmacologically safe profile of melatonin, mean it is a potentially useful tool both in its own right and to complement the treatment of obesity. Sleeping in the dark and consuming these foodstuffs could help control weight gain and prevent cardiovascular diseases associated with obesity and dyslipidemia.

The studycoordinated by University of Granada lecturer Ahmad Agilshowed that chronic administration of melatonin sensitizes the thermogenic effect of exposure to cold, heightens the thermogenic effect of exercise and, therefore, constitutes excellent therapy against obesity. The fact is that one of the key differences between 'beige fat', which appears when administering melatonin, and 'white fat', is that 'beige fat' cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

The studyauthored by Aroa Jimnez-Aranda, Gumersindo Fernndez-Vzquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agilhas been part-financed and supported by the Granada Research of Excellence Initiative on BioHealth (GREIB), the University of Granada Vice-Rectorate for Scientific Policy and Research, and the regional government of Andalusia research group CTS-109.

Given the importance of this discovery, the researchers are confident they will obtain the funding needed to continue their worksays principle researcher Ahmad Agil"and be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes".


Contact: Ahmad Agil
University of Granada

Related biology news :

1. Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
2. Pitt team finds melatonin delays ALS symptom onset and death in mice
3. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
4. Study helps bring genomes dark matter into light
5. Discovery helps to unlock brains speech-learning mechanism
6. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
7. High-angle helix helps bacteria swim
8. Researchers discover protein that helps plants tolerate drought, flooding, other stresses
9. $20,000 APS Foundation grant helps fund TGen2School education initiative
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons
Post Your Comments:
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. ... human interface solutions, today announced expansion of its ... ™ touch controller and display driver integration ... of smartphones. These new TDDI products add to ... (HD resolution), TD4302 (WQHD resolution), and TD4322 (FHD ...
(Date:11/11/2015)... Minn. , Nov. 11, 2015   MedNet Solutions ... entire spectrum of clinical research, is pleased to announce that ... in Clinical Trials (PCT) event, to be held November ... be able to view live demonstrations of iMedNet ... and learn how iMedNet has been able to ...
(Date:11/9/2015)... JOSE, Calif. , Nov. 9, 2015  Synaptics ... human interface solutions, today announced broader entry into the ... vehicle-specific solutions that match the pace of consumer electronics ... and biometric sensors are ideal for the automotive industry ... vehicle. Europe , ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Muncie, IN (PRWEB) , ... November 25, 2015 ... ... Aeronautics (AMA) and the Organization of Black Aerospace Professionals (OPBAP) has been formalized ... Mathewson and other AMA team leaders met with OPBAP leaders Capt. Karl Minter ...
(Date:11/25/2015)... PORTLAND, Oregon , November 25, 2015 /PRNewswire/ ... Deep Market Research Report is a professional and ... Genomics industry.      (Logo: ... basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including ...
(Date:11/24/2015)... , Nov. 24, 2015  Asia-Pacific (APAC) ... research organisation (CRO) market. The trend of outsourcing ... lower margins but higher volume share for the ... and scale, however, margins in the CRO industry ... (CRO) Market ( ), finds that ...
(Date:11/24/2015)... Nov. 24, 2015 Cepheid (NASDAQ: CPHD ... at the following conference, and invited investors to participate ...      Tuesday, December 1, 2015 at 11.00 a.m. ...      Tuesday, December 1, 2015 at 11.00 a.m. ... New York, NY      Tuesday, December ...
Breaking Biology Technology: