Navigation Links
Melatonin helps control weight gain as it stimulates the appearance of 'beige fat'
Date:9/25/2013

Melatonin is a natural hormone segregated by the body and melatonin levels generally increase in the dark at night. It is also found in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries.

Spanish scientists have discovered that melatonin consumption helps control weight gain because it stimulates the appearance of 'beige fat', a type of fat cell that burns calories in vivo instead of storing them. White adipose tissue stores calories leading to weight gain whereas 'beige fat' (also known as 'good or thinning fat') helps regulate body weight control, hence its metabolic benefits.

In the Journal of Pineal Research, scientists from the University of Granada Institute for Neuroscience, the Hospital Carlos III, Madrid, and the University of Texas Health Science Center in San Antonio (USA) have revealed, for the first time, the previously unknown enigma of why melatonin has metabolic benefits in treating diabetes and hyperlipidemia.

In earlier publications, the researchers analysed the effects of melatonin on obesity, dyslipidemia, high blood pressure and type 2 diabetes mellitus associated with obesity in young obese diabetic Zucker ratsan experimental model of metabolic syndrome.

In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of 'beige fat' in obese diabetic rats, but also increases its presence in thin animals used as a control group. 'Beige fat' cells are found in scattered lentil-sized deposits beneath the inguinal skin in obese diabetic Zucker rats.

Melatonin is a natural hormone segregated by the human body itself and melatonin levels generally increase in the dark at night. It is also found in small quantities in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries. These findings, together with the pharmacologically safe profile of melatonin, mean it is a potentially useful tool both in its own right and to complement the treatment of obesity. Sleeping in the dark and consuming these foodstuffs could help control weight gain and prevent cardiovascular diseases associated with obesity and dyslipidemia.

The studycoordinated by University of Granada lecturer Ahmad Agilshowed that chronic administration of melatonin sensitizes the thermogenic effect of exposure to cold, heightens the thermogenic effect of exercise and, therefore, constitutes excellent therapy against obesity. The fact is that one of the key differences between 'beige fat', which appears when administering melatonin, and 'white fat', is that 'beige fat' cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

The studyauthored by Aroa Jimnez-Aranda, Gumersindo Fernndez-Vzquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agilhas been part-financed and supported by the Granada Research of Excellence Initiative on BioHealth (GREIB), the University of Granada Vice-Rectorate for Scientific Policy and Research, and the regional government of Andalusia research group CTS-109.

Given the importance of this discovery, the researchers are confident they will obtain the funding needed to continue their worksays principle researcher Ahmad Agil"and be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes".


'/>"/>

Contact: Ahmad Agil
aagil@ugr.es
34-958-243-538
University of Granada
Source:Eurekalert

Related biology news :

1. Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
2. Pitt team finds melatonin delays ALS symptom onset and death in mice
3. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
4. Study helps bring genomes dark matter into light
5. Discovery helps to unlock brains speech-learning mechanism
6. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
7. High-angle helix helps bacteria swim
8. Researchers discover protein that helps plants tolerate drought, flooding, other stresses
9. $20,000 APS Foundation grant helps fund TGen2School education initiative
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... regulatory and technical consulting, provides a free webinar on Performing Quality ... 13, 2016 at 12pm CT at no charge. , Incomplete investigations are still ...
Breaking Biology Technology: