Navigation Links
Melatonin helps control weight gain as it stimulates the appearance of 'beige fat'
Date:9/25/2013

Melatonin is a natural hormone segregated by the body and melatonin levels generally increase in the dark at night. It is also found in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries.

Spanish scientists have discovered that melatonin consumption helps control weight gain because it stimulates the appearance of 'beige fat', a type of fat cell that burns calories in vivo instead of storing them. White adipose tissue stores calories leading to weight gain whereas 'beige fat' (also known as 'good or thinning fat') helps regulate body weight control, hence its metabolic benefits.

In the Journal of Pineal Research, scientists from the University of Granada Institute for Neuroscience, the Hospital Carlos III, Madrid, and the University of Texas Health Science Center in San Antonio (USA) have revealed, for the first time, the previously unknown enigma of why melatonin has metabolic benefits in treating diabetes and hyperlipidemia.

In earlier publications, the researchers analysed the effects of melatonin on obesity, dyslipidemia, high blood pressure and type 2 diabetes mellitus associated with obesity in young obese diabetic Zucker ratsan experimental model of metabolic syndrome.

In view of their most recent results, it seems the key lies in the fact that chronic melatonin consumption not only induces the appearance of 'beige fat' in obese diabetic rats, but also increases its presence in thin animals used as a control group. 'Beige fat' cells are found in scattered lentil-sized deposits beneath the inguinal skin in obese diabetic Zucker rats.

Melatonin is a natural hormone segregated by the human body itself and melatonin levels generally increase in the dark at night. It is also found in small quantities in fruit and vegetables like mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries. These findings, together with the pharmacologically safe profile of melatonin, mean it is a potentially useful tool both in its own right and to complement the treatment of obesity. Sleeping in the dark and consuming these foodstuffs could help control weight gain and prevent cardiovascular diseases associated with obesity and dyslipidemia.

The studycoordinated by University of Granada lecturer Ahmad Agilshowed that chronic administration of melatonin sensitizes the thermogenic effect of exposure to cold, heightens the thermogenic effect of exercise and, therefore, constitutes excellent therapy against obesity. The fact is that one of the key differences between 'beige fat', which appears when administering melatonin, and 'white fat', is that 'beige fat' cell mitochondria express levels of UCP1 protein, responsible for burning calories and generating heat.

The studyauthored by Aroa Jimnez-Aranda, Gumersindo Fernndez-Vzquez, Daniel Campos, Mohamed Tassi, Lourdes Velasco-Perez, Tx Tan, Russel J. Reiter and Ahmad Agilhas been part-financed and supported by the Granada Research of Excellence Initiative on BioHealth (GREIB), the University of Granada Vice-Rectorate for Scientific Policy and Research, and the regional government of Andalusia research group CTS-109.

Given the importance of this discovery, the researchers are confident they will obtain the funding needed to continue their worksays principle researcher Ahmad Agil"and be able to achieve their final objective: to confirm these findings in humans, by administering melatonin to help combat obesity and diabetes".


'/>"/>

Contact: Ahmad Agil
aagil@ugr.es
34-958-243-538
University of Granada
Source:Eurekalert

Related biology news :

1. Melatonin pre-treatment is a factor that impacts stem cell survival after transplantation
2. Pitt team finds melatonin delays ALS symptom onset and death in mice
3. FASEB SRC announces conference registration open for: Melatonin Biology: Actions & Therapeutics
4. Study helps bring genomes dark matter into light
5. Discovery helps to unlock brains speech-learning mechanism
6. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
7. High-angle helix helps bacteria swim
8. Researchers discover protein that helps plants tolerate drought, flooding, other stresses
9. $20,000 APS Foundation grant helps fund TGen2School education initiative
10. UT Southwestern researchers identify novel mechanism that helps stomach bug cause illness
11. Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
(Date:3/23/2017)... 23, 2017 The report "Gesture Recognition and Touchless Sensing ... Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is expected ... 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give ... Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los Angeles ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... event entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, ... was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
Breaking Biology Technology: