Navigation Links
Melanoma treatment options 1 step closer
Date:10/20/2009

A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.

U of A chemistry professor Dennis Hall said after three years of work, his research team has successfully produced the substance called Palmerolide A.

"The potency of palmerolide is exceptional and melanoma is a very aggressive cancer for which there is almost no chemotherapeutic recourse," said Hall. "Natural substances like palmerolide offer real hope for such treatments.

"Current chemotherapy as an overall strategy is not very effective in treating melanoma. Less than a quarter of patients respond to chemotherapy and it typically only works for less than a year, and it has little to no effect on survival time. Palmerolide A as a targeted therapy may prove to be more effective [for treatment] with less toxicity," said Hall.

"One of the problems with most cancer drugs is the lack of selectivity for cancer cells versus normal cells. Preliminary data for Palmerolide A looks very promising in terms of solving this issue," he said.

"For commercialization, the structure needs to be made more 'drug-like;' smaller and more water-soluble, while preserving the potency," said Hall, who is optimistic that his U of A team is moving forward in the race to develop a treatment for melanoma.


'/>"/>

Contact: Wanda Vivequin
wanda.vivequin@ualberta.ca
780-492-4073
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Trial of new treatment for advanced melanoma shows rapid shrinking of tumors
2. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
3. Zebrafish provide a model for cancerous melanoma in humans
4. New method for detection of phosphoproteins reveals regulator of melanoma invasion
5. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
6. Stress may hasten the growth of melanoma tumors
7. GUMC researchers find gene function lost in melanoma and glioblastoma
8. Vitiligo skin disorder could yield clues in fight against melanoma
9. Variant of vitamin D receptor gene linked to melanoma risk
10. As rates rise, researchers find better way to identify melanoma
11. New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... PUNE, India , December 1, 2016 /PRNewswire/ ... Market by Authentication type (Fingerprint, Voice), Future Technology (Iris ... Vehicle), and Region - Global Forecast to 2021", ... be USD 442.7 Million in 2016, and is ... 2021, at a CAGR of 14.06%. ...
(Date:11/30/2016)... 2016  higi SH llc (higi) announced today ... national brands, industry thought-leaders and celebrity influencers looking ... for taking steps to live healthier, more active ... higi has built the largest self-screening health station ... people who have conducted over 185 million biometric ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's ... Systems) ... largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of an ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 2016 Savannah River Remediation LLC group ... NewTechBio,s NT-MAX Lake & Pond Sludge and ... in conjunction with Hexa Armor/ Rhombo cover manufactured ... Pollutant Discharge Elimination System requirements. The ... history of elevated pH levels, above 8.5, especially ...
(Date:12/7/2016)... ... December 07, 2016 , ... ACEA Biosciences, Inc. presented today ... clinical trial for its lead drug candidate, AC0010, at the World Conference on ... to determine the safety, antitumor activity, and recommended phase II dosage of AC0010 ...
(Date:12/7/2016)... 2016 /PRNewswire/ - OncoQuest Inc. ("OncoQuest"), a biopharmaceutical ... immunotherapeutic products for the treatment of cancer, today ... Manufacturing Development Program with Cytovance Biologics ( ... oregovomab antibody product. Supported by recent positive interim ... in ovarian cancer patients, OncoQuest has engaged Cytovance ...
(Date:12/7/2016)... The report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection ... to 2026", published by MarketsandMarkets, the global market size was USD 645.4 Million ... an of CAGR of 6.2% between 2016 and 2026. ... ... , , ...
Breaking Biology Technology: