Navigation Links
Melanoma treatment options 1 step closer
Date:10/20/2009

A targeted chemotherapy for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.

U of A chemistry professor Dennis Hall said after three years of work, his research team has successfully produced the substance called Palmerolide A.

"The potency of palmerolide is exceptional and melanoma is a very aggressive cancer for which there is almost no chemotherapeutic recourse," said Hall. "Natural substances like palmerolide offer real hope for such treatments.

"Current chemotherapy as an overall strategy is not very effective in treating melanoma. Less than a quarter of patients respond to chemotherapy and it typically only works for less than a year, and it has little to no effect on survival time. Palmerolide A as a targeted therapy may prove to be more effective [for treatment] with less toxicity," said Hall.

"One of the problems with most cancer drugs is the lack of selectivity for cancer cells versus normal cells. Preliminary data for Palmerolide A looks very promising in terms of solving this issue," he said.

"For commercialization, the structure needs to be made more 'drug-like;' smaller and more water-soluble, while preserving the potency," said Hall, who is optimistic that his U of A team is moving forward in the race to develop a treatment for melanoma.


'/>"/>

Contact: Wanda Vivequin
wanda.vivequin@ualberta.ca
780-492-4073
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. Trial of new treatment for advanced melanoma shows rapid shrinking of tumors
2. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
3. Zebrafish provide a model for cancerous melanoma in humans
4. New method for detection of phosphoproteins reveals regulator of melanoma invasion
5. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
6. Stress may hasten the growth of melanoma tumors
7. GUMC researchers find gene function lost in melanoma and glioblastoma
8. Vitiligo skin disorder could yield clues in fight against melanoma
9. Variant of vitamin D receptor gene linked to melanoma risk
10. As rates rise, researchers find better way to identify melanoma
11. New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/2/2015)... According to preliminary estimates Fingerprint ... higher than 125 MSEK. This exceeds the guidance provided ... revenues for Q1 2015 would be in line with ... 2014. The operating result for the first quarter is ... report will as previously communicated be published on May ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... early in pregnancy may have a profound and long-lasting effect ... lack of iron is not enough to cause severe anemia, ... in the scientific journal PLoS One . The ... mild or moderate iron deficiency, and therefore the study authors ...
... is pleased to announce the 2011 Student Research Achievement ... this competitive event held during the Biophysical Society Annual ... the Society,s subgroups selected twenty winners. The winners ... and received a monetary award. The winners are: ...
... EAST LANSING, Mich. When it comes to survival ... adaptable tortoise than a fitness-oriented hare, a Michigan State ... Science magazine, Richard Lenski, MSU Hannah Distinguished Professor ... more adaptable bacteria oriented toward long-term improvement prevailed over ...
Cached Biology News:Pre-conception and early pregnancy iron deficiency harms brain 2Pre-conception and early pregnancy iron deficiency harms brain 3In the race of life, better an adaptable tortoise than a fit hare 2
(Date:4/21/2015)... , April 21, 2015  Scientists from ... genomic research organization, published a paper today outlining ... of microalgae called diatoms. The researchers, led by ... senior author Philip Weyman , Ph.D., conclude ... better understanding of diatom genetics and thus facilitate ...
(Date:4/21/2015)... YORK , April 21, 2015 Immune ... that its Board of Directors has elected Rene-Pierre ... the Transaction and Pricing Committee, with oversight on strategic ... member of the Audit Committee, the Compensation Committee and ... his election, Mr. Azria commented: "I have a long-time ...
(Date:4/21/2015)... PRC Clinical, a Clinical Trial ... ACRP 2015 Global Conference and Exhibition on April 25-28, ... Clinical Research Professionals (ACRP) Global Conference and Exhibition is ... the conduct of clinical trials. ACRP supports clinical research ... industry certifications. , The ACRP 2015 Global Conference ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Whether it’s used ... lab, or bolted to a Kessler CineDrive in ... at the beach, the TS3-H is designed to help any ... a brand-new state-of-the-art 5MP sensor, the TS5-H offers the same ... superior imaging characteristics. , According to Tom Boldt for ...
Breaking Biology Technology:Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 2Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 3Immune Board Elects Rene-Pierre Azria A Director And Chair Of The Transaction Committee 2Immune Board Elects Rene-Pierre Azria A Director And Chair Of The Transaction Committee 3Immune Board Elects Rene-Pierre Azria A Director And Chair Of The Transaction Committee 4PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3
... Skills Related to Nutrition Care in Mosby,s Nursing Skills ... Elsevier/MC Strategies , a pioneer in providing ... today its collaboration with the American Society for ... amend the nutrition-related skills in Mosby,s Nursing Skills. , ...
... -- Using clever but elegant design, University at Buffalo ... used to capture and purify nanomaterials. , Sculpted from ... the traps consist of tiny, organic tubes whose interior ... tubes to selectively encapsulate only positively charged particles. , ...
... & Korsinsky is investigating potential claims on behalf of ... Inc. ("PacBio" or the "Company") (NASDAQ: PACB ... For more information, click here: http://zlk.9nl.com/pacific-biosciences-california-pacb/ . ... the Company failed to disclose the following: (a) that ...
Cached Biology Technology:Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 2Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 3Chemists become molecular sculptors, synthesizing tiny, molecular traps 2Chemists become molecular sculptors, synthesizing tiny, molecular traps 3The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc. 2
...
Homogenizing Solution, 18ml Proteinase K - [50ug/l] 75 l...
...
Chicken polyclonal to ADI1 ( Abpromise for all tested applications). Antigen: Full length native protein (purified), corresponding to amino acids 1-179 of Human ADI1. Entrez GeneID: 55256 ...
Biology Products: