Navigation Links
Medicines from plants
Date:5/26/2011

This release is available in German.

Medicines from plants one thinks of herbal teas or valerian drops. However, that has nothing in common with what the researchers at the Fraunhofer Institute for Molecular Biology and Applied Ecology IME in Aachen, Germany, are doing. They use plants to produce biopharmaceuticals. Those are proteins that, unlike many other medications, cannot be chemically produced.

Biologically produced medications, such as recombinant insulin or therapeutic antibodies to fight cancer, have become indispensable. Plants are particularly suitable for producing complex active substances. The reason is that these substances can be produced inexpensively and on a large scale in plants. Compared to producing them in animal cells, plants have the advantage that they grow quickly, are easy to look after and can be protected well against damaging influences.

Precisely controlled raising of plants

Tobacco was the plant of choice. Dr. Jrgen Drossard explains the reason: Tobacco has long been a very interesting plant for molecular biologists. It is easy to modify, meaning a foreign gene coding for the pharmaceutical protein can be introduced. In addition, a lot of biomass grows quickly and therefore a greater quantity of the desired proteins is also produced. The active substances must be absolutely safe. It is for this reason that the requirements both for growing the plants and for the processes and equipment for the preparations are particularly high. The researchers from Aachen passed the stringent tests of the supervisory and approval authorities for both. The tobacco plants are protected from all external influences and grown under precisely controlled conditions. We practically grow them on sterile substrates. And fertilization with manure is absolutely out of the question, of course, says Dr. Thomas Rademacher.

But growing the plants only solved a part of the problem. Because, how does one get as much protein as possible from the leaves that are harvested? The team developed the equipment that is suitable for that itself, because current processes, coming from food technology, for example, work on an entirely different scale. The complete pulping process now takes place in a closed loop.

Biopharmaceuticals for clinical studies

Dr. Jrgen Drossard, Dr. Thomas Rademacher and Dr. Stefan Schillberg from the IME, in cooperation with Prof. Dr. Wiltrud Treffenfeldt from Dow AgroSciences and Dr. ctive substances in transgenic plants and plant suspension cells economically and safely. They are being honored with the Prize for Human-Centered Technology for their achievements.

We wanted to show that it can be done, that biopharmaceuticals can be produced that are suitable for clinical studies, says Dr. Stefan Schillberg of the IME. And this is exactly where the team is at with its development. The proteins that are produced in this manner are currently being tested with the objective that they be used in clinical studies. For example, the antibodies could be used to manufacture a vaginal gel with which women could protect themselves from an HIV infection. In a new project, the researchers are currently working on producing a malaria vaccine in plants.


'/>"/>

Contact: Dr. Stefan Schillberg
stefan.schillberg@ime.fraunhofer.de
49-241-608-511-050
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related biology news :

1. Accelerated lab evolution of biomolecules could yield new generation of medicines
2. Sunlight can influence the breakdown of medicines in the body
3. New treaty on search for life-saving medicines in remote areas
4. 40-year-old test procedure finds modern niche in developing new medicines
5. Reducing gene-damaging impurities in medicines
6. Problem of fake medicines in developing countries could be solved
7. Insight into cells could lead to new approach to medicines
8. Toward bold new anti-cancer medicines
9. Quality of medicines and food ingredients the focus at USP 2009 Annual Scientific Meeting
10. Comprehensive genetic study paves way for new blood-pressure medicines
11. Research exposes the risk to infants from the chemicals used in liquid medicines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Medicines from plants
(Date:1/25/2016)... SEATTLE , Jan. 25, 2016  Glencoe Software, ... biotech, pharma and publication industries, will provide the data ... Phenotypic Screening Centre (NPSC). ... Phenotypic analysis ... even whole organisms, allowing comparisons between states such as ...
(Date:1/20/2016)... Minn. , Jan. 20, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... 2015. MedNet,s significant achievements are the result of the ... iMedNet eClinical , it,s comprehensive, easy-to-use ... --> --> Key MedNet growth achievements ...
(Date:1/13/2016)... , January 13, 2016 ... the addition of the  "India Biometrics ... & Forecast (2015-2020)"  report to ... ) has announced the addition of ... Market - Estimation & Forecast (2015-2020)" ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... DIEGO, Feb. 11, 2016  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ... ended December 31, 2015. --> ... a net loss of $29.3 million, or $0.34 loss per share, ... per share for the same period in 2014. For the year ... $88.9 million, or $1.05 loss per share, as compared to a ...
(Date:2/11/2016)... , Germany and ... QGEN ; Frankfurt Prime Standard: QIA) today ... Targeted RNA Panels for gene expression profiling, expanding QIAGEN,s ... (NGS). The panels enable researchers to select from over ... changes and discover interactions between genes, cellular phenotypes and ...
(Date:2/11/2016)... 2016  Spectra BioPharma Selling Solutions (Spectra) is ... biopharma companies the experience, expertise, operational delivery and ... sales teams. Created in concert with industry leading ... strategic and tactical needs of its clients by ... both personal and non-personal promotion. ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... dedicated to delivering cutting-edge information focused on the development and manufacture of ... become a premier sponsor of the 2016 BioProcess International Awards – Recognizing ...
Breaking Biology Technology: