Navigation Links
Medicines from plants
Date:5/26/2011

This release is available in German.

Medicines from plants one thinks of herbal teas or valerian drops. However, that has nothing in common with what the researchers at the Fraunhofer Institute for Molecular Biology and Applied Ecology IME in Aachen, Germany, are doing. They use plants to produce biopharmaceuticals. Those are proteins that, unlike many other medications, cannot be chemically produced.

Biologically produced medications, such as recombinant insulin or therapeutic antibodies to fight cancer, have become indispensable. Plants are particularly suitable for producing complex active substances. The reason is that these substances can be produced inexpensively and on a large scale in plants. Compared to producing them in animal cells, plants have the advantage that they grow quickly, are easy to look after and can be protected well against damaging influences.

Precisely controlled raising of plants

Tobacco was the plant of choice. Dr. Jrgen Drossard explains the reason: Tobacco has long been a very interesting plant for molecular biologists. It is easy to modify, meaning a foreign gene coding for the pharmaceutical protein can be introduced. In addition, a lot of biomass grows quickly and therefore a greater quantity of the desired proteins is also produced. The active substances must be absolutely safe. It is for this reason that the requirements both for growing the plants and for the processes and equipment for the preparations are particularly high. The researchers from Aachen passed the stringent tests of the supervisory and approval authorities for both. The tobacco plants are protected from all external influences and grown under precisely controlled conditions. We practically grow them on sterile substrates. And fertilization with manure is absolutely out of the question, of course, says Dr. Thomas Rademacher.

But growing the plants only solved a part of the problem. Because, how does one get as much protein as possible from the leaves that are harvested? The team developed the equipment that is suitable for that itself, because current processes, coming from food technology, for example, work on an entirely different scale. The complete pulping process now takes place in a closed loop.

Biopharmaceuticals for clinical studies

Dr. Jrgen Drossard, Dr. Thomas Rademacher and Dr. Stefan Schillberg from the IME, in cooperation with Prof. Dr. Wiltrud Treffenfeldt from Dow AgroSciences and Dr. ctive substances in transgenic plants and plant suspension cells economically and safely. They are being honored with the Prize for Human-Centered Technology for their achievements.

We wanted to show that it can be done, that biopharmaceuticals can be produced that are suitable for clinical studies, says Dr. Stefan Schillberg of the IME. And this is exactly where the team is at with its development. The proteins that are produced in this manner are currently being tested with the objective that they be used in clinical studies. For example, the antibodies could be used to manufacture a vaginal gel with which women could protect themselves from an HIV infection. In a new project, the researchers are currently working on producing a malaria vaccine in plants.


'/>"/>

Contact: Dr. Stefan Schillberg
stefan.schillberg@ime.fraunhofer.de
49-241-608-511-050
Fraunhofer-Gesellschaft
Source:Eurekalert  

Related biology news :

1. Accelerated lab evolution of biomolecules could yield new generation of medicines
2. Sunlight can influence the breakdown of medicines in the body
3. New treaty on search for life-saving medicines in remote areas
4. 40-year-old test procedure finds modern niche in developing new medicines
5. Reducing gene-damaging impurities in medicines
6. Problem of fake medicines in developing countries could be solved
7. Insight into cells could lead to new approach to medicines
8. Toward bold new anti-cancer medicines
9. Quality of medicines and food ingredients the focus at USP 2009 Annual Scientific Meeting
10. Comprehensive genetic study paves way for new blood-pressure medicines
11. Research exposes the risk to infants from the chemicals used in liquid medicines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Medicines from plants
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
Breaking Biology Technology: