Navigation Links
Medical researchers in Canada and the US discover hidden side of prion diseases
Date:11/30/2011

Medical researchers in Canada and the United States recently published their joint findings that fatal prion diseases, which include BSE or "mad cow disease," have a hidden signature.

Findings published this month in the peer-reviewed journal, Public Library of Science (PLoS) Pathogens, demonstrate that up to seven months before an animal shows physical signs of having a prion infection, a particular prion protein in the brain was being eradicated. This member of the prion family is known as shadoo protein.

"What we discovered is that as the early prion disease process unfolds in an infected brain, that the shadoo protein is simultaneously disappearing," said lead author and co-principal investigator, David Westaway, a researcher in the Faculty of Medicine & Dentistry at the University of Alberta.

"This is telling us there is a process within the disease that we were previously unaware of, a process that is happening before the infected animals are getting sick. It's telling us that the brain cells are more active in defending themselves than what we thought they were. The brain cells are in fact trying to get rid of the prion protein and as a consequence, this bystander shadoo protein is being destroyed unintentionally.

"This finding suggests that prion diseases are dynamic and not necessarily unstoppable, that there could be a cellular process trying to destroy the infectious prions as they appear. And if we could help that process a little bit more, that might be an avenue to attenuate the disease."

Westaway, who works in both the Division of Neurology of the Faculty of Medicine & Dentistry, and the Centre for Prions and Protein Folding Diseases at the U of A, collaborated with a team of researchers from Ontario, the University of California, the Institute for Systems Biology in Washington, the McLaughlin Research Institute in Montana and a researcher in Germany, on this discovery.

The same day th
'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Roche NimbleGen and BGI develop advanced MHC region capture technology for biomedical research
2. New medical, research tool possible by probing cell mechanics
3. University Hospitals Case Medical Center unlocks mystery of dystonia with advanced imaging
4. Advanced Medical Care for At-Risk Newborns Nets Economic Benefits
5. Biotech start-up brings DNA-sequencing to the medical market
6. Medical researchers make important research link between active ingredient in saffron and MS
7. Athens Regional Medical Center Upgrades to Omnicell G4 Platform for Supply and Medication Management
8. Manufacturing microscale medical devices for faster tissue engineering
9. Lung regeneration closer to reality with new discovery by Weill Cornell Medical College researchers
10. 21 Fellows inducted into American College of Medical Informatics
11. Researchers at NYU Langone Medical Center review the microbiome and its possible role in cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... can alleviate the symptoms of Alzheimer,s disease, ... and effectively scavenge amyloid beta peptide in ... reduced and eliminated Aβ deposition in an ... significantly improved behavioral and cognitive impairment. Dr. ... Hospital of China Medical University, China immunized ...
(Date:7/9/2014)... cancer patients with high levels of vitamin D in their ... shows. , Patients with the highest levels of vitamin ... with the lowest levels, the findings reveal. , The study ... D in bowel cancer patients after their diagnosis which ... from dietary sources with their long term survival prospects. ...
(Date:7/9/2014)... first make a copy of its DNA, a fundamental step ... times a day in the human body. While scientists have ... to replicate DNAthe enzymes that unzip the double-stranded DNA and ... how the process works. , Now, researchers at Rockefeller University ... on at the "replication fork"the point where DNA is split ...
Breaking Biology News(10 mins):Rockefeller scientists first to reconstitute the DNA 'replication fork' 2Rockefeller scientists first to reconstitute the DNA 'replication fork' 3Rockefeller scientists first to reconstitute the DNA 'replication fork' 4
... German . It would appear reasonable to assume ... blueprints. However, scientists from the Max Planck Institute for Developmental ... team have now decoded, for the first time, the entire ... a close relative of the thale cress ( Arabidopsis thaliana ...
... at the Keck School of Medicine of the University ... the first time that the human placenta plays an ... new treatment strategies that could mitigate health impacts such ... findings, conducted with researchers from Vanderbilt University as part ...
... , Berkeley In a new study suggesting pesticides ... researchers at the University of California, Berkeley,s School of Public ... widely used on food crops is related to lower ... that every tenfold increase in measures of organophosphates detected during ...
Cached Biology News:Evolution can cause a rapid reduction in genome size 2Evolution can cause a rapid reduction in genome size 3USC research shows critical role of placenta in brain development 2Prenatal pesticide exposure tied to lower IQ in children 2Prenatal pesticide exposure tied to lower IQ in children 3Prenatal pesticide exposure tied to lower IQ in children 4
(Date:1/15/2014)...  Bill Jacobs Automotive, a group of car dealerships headquartered in ... Heartland Blood Center and offering free oil change coupons for ... Saturday, Jan. 18 at the Bill Jacobs Cadillac and Chevrolet ... http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs Auto ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
(Date:1/15/2014)... 2014 Cynvenio, a cancer diagnostics company ... genomic analysis of tumor cells in the bloodstream, today ... cancer decision support application powered by CollabRx, Inc. ... genomic test, Therapy Finder will provide breast cancer patients ...
(Date:1/15/2014)... , Jan. 15, 2014 ­ RedBrick Health , ... change technology, today announces that EmblemHealth , the ... wellness company, is now providing the RedBrick Compass health ... program, to all of its members. EmblemHealth is among ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3
... Session Highlights New Small Molecule Drug ... ... Inc.,(Nasdaq: ENMD ), a clinical-stage pharmaceutical company developing,therapeutics for the ... and mechanism of action data for,its selective kinase inhibitor, ENMD-2076. On ...
... (Nasdaq: IMRX ) today announced that it received ... that for the last 30,consecutive business days, the bid ... share. As a result, the company fails to comply ... forth in,Marketplace Rule 4310(c)(4)., In accordance with Marketplace ...
... SGN ) has confirmed that it has filed ... Officer, Dr. Lowell T. Harmison, has,scheduled a webcast on ... Harmison stated: "Now that Signalife has closed filing the,company,s ... I am pleased to provide direction on new contracts, ...
Cached Biology Technology:EntreMed's Kinase Inhibitor, ENMD-2076, Presented During AACR Special Session 2EntreMed's Kinase Inhibitor, ENMD-2076, Presented During AACR Special Session 3ImaRx Therapeutics Receives Notification from NASDAQ Regarding Non-Compliance with NASDAQ's Minimum Bid Price Requirement 2Signalife Announces Webcast 2Signalife Announces Webcast 3
Whole blood is collected from healthy guinea pigs of either sex from US source which are free of visible diseases at time of blood collection. Hemolytic titer: CH50 = 435 units...
...
... Designed for serial preparation ... fractions including cytosol/particulate/cytoskeleton/nuclear fractions ... these fractions can directly ... assays such as 2-D ...
Wheat Germ Agglutinin (WGA) PS SPA Imaging Bead, 2 g. Category: Leadseeker Beads....
Biology Products: