Navigation Links
Medical researcher's discovery may explain how certain cancers develop

A Florida State University College of Medicine researcher has discovered a new interaction between a cell signaling system and a specific gene that may be the cause of B-cell lymphoma. The finding suggests a similar interaction could be occurring during the development of other types of cancer, leading to further understanding of how cancer works and how it might be stopped.

Yoichi Kato, an assistant professor in the Department of Biomedical Sciences, and his lab team found that the gene known in scientific shorthand as BCL6 can inhibit one of the pathways cells use to transmit signals to other cells. Called the Notch signaling pathway, it's an important mechanism for cells to control gene regulation.

"There are very few molecules that we know directly inhibit Notch signaling," Kato said. "So that is why the interaction, and our finding, is very interesting to people in many areas cancer specialists, neuroscientists, and many others."

Kato's team produced a paper outlining the findings that was published in the journal Developmental Cell, and Kato recently presented the paper at an international conference in Cold Spring Harbor, N.Y., for scientists studying early development of vertebrates.

Kato and his researchers have focused on the Notch signaling pathway's role in vertebrate early development. In their study, they found that when BCL6 inhibits the Notch signaling pathway during the early stages of embryo development, the alignment of the embryo's internal organs is affected, which can lead to a congenital disorder.

However, the Notch signaling pathway, which creates the equivalent of a molecular highway across a cell's membrane, is involved in many types of cell-to-cell interaction, including neuron development, stem cell differentiation and apoptosis (programmed cell death).

The fact that BCL6 regulates the Notch signaling pathway could be important for any cellular process where Notch plays a role, including the formation of many cancers. BCL6 is a gene that, when mutated in certain ways, can lead to several types of B-cell lymphoma. B-cell lymphomas, including both Hodgkin's and non-Hodgkin's lymphomas, occur when B-cells, which produce antibodies to fight infections, mutate and become cancerous.

With more study of the interaction between the Notch signaling pathway and the BCL6 gene, scientists may be able to better understand how these cancers form. Kato and his lab plan to further investigate the interaction's role in neural development, as well as how the interaction could affect stem cell formation.


Contact: Doug Carlson
Florida State University

Related biology news :

1. UM receives 5th consecutive Howard Hughes Medical Institute grant for science education
2. ScriptRx and DigitalPersona Team Up to Secure Emergency Room and Urgent Care Electronic Medical Records
3. Scientists use biomedical technique to image marine worm
4. Historic medical conference finds Bolivar may have been poisoned
5. Concord Medical Enters Agreement to Acquire Four Radiotherapy and Diagnostic Imaging Centers in Hebei Province
6. Winner Medical Group inc. Prices Offering of 1,380,000 Shares of Common Stock
7. Depression symptoms increase during medical internship
8. Chronix Biomedicals serum DNA assays monitor disease activity and treatment response in MS
9. Electronic medical records may accelerate genome-driven diagnoses and treatments
10. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
11. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
Post Your Comments:
Related Image:
Medical researcher's discovery may explain how certain cancers develop
(Date:10/29/2015)... , Oct. 29, 2015  Rubicon Genomics, Inc., ... U.S. distribution of its DNA library preparation products, ... Rubicon,s new ThruPLEX Plasma-seq kit. ThruPLEX Plasma-seq has ... preparation of NGS libraries for liquid biopsies--the analysis ... and prognostic applications in cancer and other conditions. ...
(Date:10/27/2015)... -- In the present market scenario, security is one ... verticals such as banking, healthcare, defense, electronic gadgets, and ... secure & simplified access control and growing rate of ... bank accounts, misuse of users, , and so on. ... and smartphones are expected to provide potential opportunities for ...
(Date:10/26/2015)... and LAS VEGAS , Oct. ... Labs , an innovator in modern authentication and a ... announced the launch of its latest version of the ... enabling organizations to use standards-based authentication that supports existing ... S3 Authentication Suite is ideal for organizations deploying customer-facing ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... PA (PRWEB) , ... November 27, 2015 , ... ... Technical Program that includes over 2,000 technical presentations offered in symposia, oral ... chemistry and applied spectroscopy, covers a wide range of applications such as, but ...
(Date:11/26/2015)... MUMBAI , November 26, 2015 ... --> Accutest Research ... accredited Contract Research Organization (CRO), has ... Chase Cancer Center - Temple Health ... ,     (Photo: ) ...
(Date:11/25/2015)... , November 26, 2015 ... Global Biobanking Market 2016 - 2020 report analyzes ... maintaining integrity and quality in long-term samples, minimizing ... long-term cost-effectiveness. Automation minimizes manual errors such as ... technical efficiency. Further, it plays a vital role ...
(Date:11/25/2015)... -- 2 nouvelles études permettent d , ... entre les souches bactériennes retrouvées dans la plaque ... . Ces recherches  ouvrent une nouvelle voie ... efficace de l,un des problèmes de santé les ...    --> 2 nouvelles études permettent d ...
Breaking Biology Technology: