Navigation Links
Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies

See it for yourself: a new breakthrough in imaging technology using a combination of light and sound will allow health care providers to see microscopic details inside the body. Access to this level of detail potentially eliminates the need for some invasive biopsies, but it also has the potential to help health care providers make diagnoses earlier than ever beforeeven before symptoms arise. Details describing this advance are published online in the FASEB Journal (

In the online research report, researchers from St. Louis describe how they combined photoacoustic tomography (PAT) with gold nanobeacons (GNB) to achieve an unprecedented level of imaging detail. Specifically, the researchers were able to identify the first signs of new blood vessel growth, which is necessary for new tumors to form. Specifically, not only were the newest blood vessels with initial blood flow imaged, but pre-vessel formation of inter-vessel bridges and vessel off-shoot sprouts in which blood flow had yet to begin also were captured. This is the first time that the angiogenic process was imaged in such clear detail without a microscope. The scientists anticipate that the combined use of PAT and GNB will be able to further pinpoint precise molecular disease markers.

According to one of the researchers involved in the work, Dipanjan Pan, Ph.D. from the Consortium for Translational Research in Advanced Imaging and Nanomedicine at the Washington University School of Medicine, "This study further establishes the opportunity provided by molecular imaging and photoacoustic tomography to identify, characterize, and guide the rational management of high-risk patients with life-threatening disease earlier when treatment is the most likely to help and quality of life is best preserved."

To make this advance, the researchers implanted mice with a gel (Matrigel) that stimulates natural capillary formation, mimicking the same process occurring in an aggressive cancer or unstable atherosclerotic plaque. Then they used GNB to target a prominent molecular indicator of proliferating new vessels. Unlike common ultrasound techniques that send in a sound wave and "listen" for the echo, PAT sends in a light beam that excites and warms certain proteins, such as the hemoglobin in red blood cells. The minutely heated proteins emit a sound wave that is then detected by the ultrasound transducer.

"This type of imaging verges on Star Trek territory," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "We're now exploring inner space with tools developed for outer space.

Early tumors and latent infections give rise to microscopic changes in blood vessels that no one could pick up until this technique came along. It's the new age of nanomedicine."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. Researchers design artificial cells that could power medical implants
3. Salk scientist Fred H. Gage to receive the Keio Medical Science Prize
4. New book dissects statistics for doctors and medical students
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. A card-swipe for medical tests
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
11. New book helps medical students master clinical skills
Post Your Comments:
(Date:11/2/2015)... 2015  SRI International has been awarded a contract ... services to the National Cancer Institute (NCI) PREVENT Cancer ... expertise, modern testing and support facilities, and analytical instrumentation ... toxicology studies to evaluate potential cancer prevention drugs. ... Cancer Drug Development Program is an NCI-supported pipeline to ...
(Date:10/29/2015)... health pioneer, Joseph C. Kvedar , MD, describes ... wellness, and the business opportunities that arise from it ... Healthy Things . Long before health and wellness ... vice president, Connected Health, Partners HealthCare, was creating a ... the hospital or doctor,s office into the day-to-day lives ...
(Date:10/27/2015)... SAN JOSE, Calif. , Oct. 27, 2015 /PRNewswire/ ... human interface solutions, today announced that Google has adopted ... family of touch controller solutions to power its newest ... Nexus 6P by Huawei. --> ... ecosystem partners like Google to provide strategic collaboration in ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... Dec. 1, 2015  CardioCell LLC, a Stemedica ... cells for cardiovascular indications, intends to proceed with ... on recommendations from a Heart Failure Advisory Board ... Scientific Advisory Board members . In a recent ... IIa safety and efficacy data from CardioCell,s on-going ...
(Date:12/1/2015)... Cepheid (Nasdaq: CPHD ) today announced ... Jaffray Healthcare Conference in New York City ... its outlook for the fourth quarter of 2015 and ... longer term business model expectations. John Bishop ... to be the fastest growing company of the major ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... physicians, aesthetic practitioners and aesthetics professionals from Central America and abroad for the ... in Panama City, Panama Feb. 17-19, 2016. Testart will present and discuss new ...
(Date:11/30/2015)... , Dec. 1, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... it has joined the American Business Act on Climate Pledge, ... that are standing with the Obama Administration to demonstrate an ... a strong outcome to the COP21 Paris ... --> Sarnia, Canada . --> ...
Breaking Biology Technology: