Navigation Links
Medical imaging breakthrough uses light and sound to see microscopic details inside our bodies
Date:11/22/2010

See it for yourself: a new breakthrough in imaging technology using a combination of light and sound will allow health care providers to see microscopic details inside the body. Access to this level of detail potentially eliminates the need for some invasive biopsies, but it also has the potential to help health care providers make diagnoses earlier than ever beforeeven before symptoms arise. Details describing this advance are published online in the FASEB Journal (http://www.fasebj.org/content/early/2010/11/19/fj.10-171728.abstract).

In the online research report, researchers from St. Louis describe how they combined photoacoustic tomography (PAT) with gold nanobeacons (GNB) to achieve an unprecedented level of imaging detail. Specifically, the researchers were able to identify the first signs of new blood vessel growth, which is necessary for new tumors to form. Specifically, not only were the newest blood vessels with initial blood flow imaged, but pre-vessel formation of inter-vessel bridges and vessel off-shoot sprouts in which blood flow had yet to begin also were captured. This is the first time that the angiogenic process was imaged in such clear detail without a microscope. The scientists anticipate that the combined use of PAT and GNB will be able to further pinpoint precise molecular disease markers.

According to one of the researchers involved in the work, Dipanjan Pan, Ph.D. from the Consortium for Translational Research in Advanced Imaging and Nanomedicine at the Washington University School of Medicine, "This study further establishes the opportunity provided by molecular imaging and photoacoustic tomography to identify, characterize, and guide the rational management of high-risk patients with life-threatening disease earlier when treatment is the most likely to help and quality of life is best preserved."

To make this advance, the researchers implanted mice with a gel (Matrigel) that stimulates natural capillary formation, mimicking the same process occurring in an aggressive cancer or unstable atherosclerotic plaque. Then they used GNB to target a prominent molecular indicator of proliferating new vessels. Unlike common ultrasound techniques that send in a sound wave and "listen" for the echo, PAT sends in a light beam that excites and warms certain proteins, such as the hemoglobin in red blood cells. The minutely heated proteins emit a sound wave that is then detected by the ultrasound transducer.

"This type of imaging verges on Star Trek territory," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "We're now exploring inner space with tools developed for outer space.

Early tumors and latent infections give rise to microscopic changes in blood vessels that no one could pick up until this technique came along. It's the new age of nanomedicine."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. Researchers design artificial cells that could power medical implants
3. Salk scientist Fred H. Gage to receive the Keio Medical Science Prize
4. New book dissects statistics for doctors and medical students
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. A card-swipe for medical tests
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
11. New book helps medical students master clinical skills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , Aug. 16, 2017  This year,s edition of the Inc. ... in life sciences workforce solutions, has made the list for the third ... recognizes the nation,s fastest-growing private companies based on a set of quantitative ... which includes the fastest-growing companies in the Bay State ... Inc. 5000 ...
(Date:8/15/2017)... NC (PRWEB) , ... August 15, 2017 , ... ... 2017, celebrating 10 years of successes helping medical technology companies and inventors develop and ... to a renowned full-service national engineering firm with a portfolio of clients in the ...
(Date:8/15/2017)... , ... August 15, 2017 , ... Any expert in ... has compromised these disciplines for more than half a century. Despite their essential ... It is widely known that molecular tags developed for this purpose also tag ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... and is threatened by various biotic and abiotic factors. During this educational webinar, ... history of coffee, as well as gain a better understanding of how genomics ...
Breaking Biology Technology: