Navigation Links
Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers
Date:1/6/2008

to the death of the surrounding muscular tissue. This was a very surprising result, since the muscle received too little oxygen to survive under normal circumstances. In the mice lacking the PHD1 oxygen meter, the tissue apparently reprogrammed itself by means of a metabolic shift, so that the muscle needed less oxygen in order to continue to function. Furthermore, less oxygen in the muscle meant fewer toxic oxygen particles and thus less damage. So, the muscle could use the little oxygen that was available in a better and safer manner. These alterations enabled the muscle to stay perfectly healthy in these normally life-threatening conditions. In addition, the researchers also demonstrated that treating healthy mice even briefly with a PHD1-blocker could protect the muscles against oxygen deficiency - which opens a path to new therapies.

New therapeutic possibilities?

These findings have significant implications for several medical applications. Scientists can now begin to investigate whether PHD1-blockers can prevent the damage caused by blockage of a blood vessel through thrombosis or after a heart attack (in which the cardiac muscle experiences a shortage of oxygen). New treatment alternatives may also be possible for strokes, and surgeons may also be able to reduce the oxygen supply to organs for a longer period of time during many types of operations.

The absence of PHD1 might also explain the mysterious adaptations of hibernating animals, with important implications for the preservation of organs for transplant. Such tissues often have to contend with prolonged oxygen deficiency, which destroys their viability for transplantation. If these organs could be kept in a hibernation condition, perhaps more lives could be saved...


'/>"/>

Contact: Joke Comijn
joke.comijn@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology news :

1. UVa biomedical engineering study shows magnetic field can reduce swelling
2. New report finds great potential for Swedish medical technology
3. Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network
4. Titanium Group Signs Letter of Intent to Acquire Multimilion Dollar Medical Software Company and Its Existing Sales Network
5. Triage study challenges notions of emergency medical response to disaster
6. Natural product discovery by Cleveland medical researchers blocks tissue destruction
7. UMass Medical School researchers receive $8.5M grant award to fight AIDS
8. Phase 2 of Singapores Biomedical Sciences Initiative gains momentum for clinical research
9. 3 Columbia University Medical Center faculty elected to Institute of Medicine
10. USC biomedical team to participate in $6 million low vision project
11. $22 million gift from Alfred Taubman launches new biomedical research institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... State University shows that urban "heat islands" are slowly ... factor is that researchers have found warmer temperatures increase ... insect a significant tree pest by 300 ... adult gloomy scales on urban trees. , "We,d been ... scale in cities, and now we know why," says ...
(Date:7/23/2014)... of Antarctic fur seals, alongside decades of in-depth ... of climate change on a population of top-predators. ... findings show that the seals have significantly altered ... are associated with climate conditions. Despite a shift ... is not passing down through generations, leaving the ...
(Date:7/23/2014)... Popeye super strength, but it also holds the promise ... the ability to convert sunlight into a clean, efficient ... an international group using spinach to study the proteins ... the sun,s energy into carbohydrates used to power cellular ... the most efficient system ever built, capable of converting ...
Breaking Biology News(10 mins):Urban heat boosts some pest populations 200-fold, killing red maples 2Urban heat boosts some pest populations 200-fold, killing red maples 3Genetic study shows major impact of climate change on Antarctic fur seals 2Genetic study shows major impact of climate change on Antarctic fur seals 3Spinach could lead to alternative energy more powerful than Popeye 2
... up with a new twist on the mysterious visual ... The scientists have found that monkeys sense it too. ... Japanese researcher nearly three decades ago, describes that disquieting ... to be as human-like as possible -- whether computer ...
... are setting their minimum population size targets too low ... by University of Adelaide and Macquarie University scientists which ... to persist in the face of global climate change ... individuals or more. The findings have been published online ...
... multi-national research team has discovered that two genetic factors converge ... investigators from the United States, Italy and South Africa ... in the gene NOS1AP increase the risk of cardiac symptoms ... disease called congenital long-QT syndrome. , The findings will help ...
Cached Biology News:Like humans, monkeys fall into the 'uncanny valley' 2Like humans, monkeys fall into the 'uncanny valley' 3Conservation targets too small to stop extinction 2Gene mingling increases sudden death risk 2Gene mingling increases sudden death risk 3
(Date:7/23/2014)... Shire plc (LSE: SHP, ... biopharmaceutical company, and ArmaGen, a US privately held ... collaboration agreement for AGT-182, an investigational enzyme replacement ... the central nervous system (CNS) and somatic manifestations ... collaboration strengthens Shire,s rare disease pipeline of innovative ...
(Date:7/23/2014)... With the ability to record continuously at over 500 ... minutes, Fastec Imaging has brought the same ease-of-use of today’s ... a high speed camera that can be used as simply ... proclaims Matt Kearney, VP of Sales for Fastec Imaging. ... simplify the traditionally complicated workflow of a high speed camera. ...
(Date:7/23/2014)... Astra Nova Training , a ... pharma training services, and the Alliance for ... non-profit integrating the expertise and investments of research ... system for clinical trials, are pleased to announce ... of industry professionals through improved and easily available ...
(Date:7/22/2014)... and Technology (NIST) and California Institute of Technology ... atomic clock that is based on a chip-scale ... clock, featured on the cover of the inaugural ... is the first demonstration of all-optical control of ... frequencies to lower microwave frequencies. (Optical frequencies are ...
Breaking Biology Technology:Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5Fastec Imaging Introduces the First High Speed Camcorder 2Fastec Imaging Introduces the First High Speed Camcorder 3Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 2Astra Nova and ACRES Partner on Quality and Access of Training for Research Professionals 3'Comb on a chip' powers new NIST/Caltech atomic clock design 2
... Highlights: - Revenues of $88.4 million, up 14% from the, prior ... 47% over last year,s third quarter - Operating cash flow of ... year 2008 ... earnings guidance, COLUMBIA, Md., Sept. 4 Martek Biosciences,Corporation (Nasdaq: ...
... The University of North Carolina-Chapel Hill ... Safety Sciences, RESEARCH TRIANGLE PARK, N.C., Sept. 4 ... of North Carolina at,Chapel Hill announced they are establishing ... led by Dr. Paul Watkins, one of the world,s ...
... -- Genesis,Pharmaceuticals Enterprises, Inc. (OTC Bulletin Board: GNPH) ... the People,s Republic,of China, today announced that it ... stock which will begin trading under the symbol ... stock will no longer trade,under the symbol "GTEC" ...
Cached Biology Technology:Martek Announces Third Quarter 2008 Financial Results 2Martek Announces Third Quarter 2008 Financial Results 3Martek Announces Third Quarter 2008 Financial Results 4Martek Announces Third Quarter 2008 Financial Results 5Martek Announces Third Quarter 2008 Financial Results 6Martek Announces Third Quarter 2008 Financial Results 7Martek Announces Third Quarter 2008 Financial Results 8Martek Announces Third Quarter 2008 Financial Results 9Martek Announces Third Quarter 2008 Financial Results 10New Hamner-UNC Center for Drug Safety Sciences 2New Hamner-UNC Center for Drug Safety Sciences 3Genesis Pharmaceuticals Completes Reverse Stock Split and Will Trade Under a New Symbol 2Genesis Pharmaceuticals Completes Reverse Stock Split and Will Trade Under a New Symbol 3
Human SEAP ORF, provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... These 2800mL PYREX Fernbach-style culture flasks ... of the flask bottom to achieve maximal ... have a large marking spot., A wide ... these bottles including:, Polypropylene colored caps ...
... Complete kit for stabilizing 400g of ... been optimised for the stabilization of aqueous ... traditional methods such as guanidine, phenol/chloroform, silica, ... Our StabMRT Kits contain all the necessary ...
...
Biology Products: