Navigation Links
Medical College of Wisconsin researchers show molecule inhibits metastasis
Date:10/10/2011

Researchers at the Medical College of Wisconsin have shown that a protein can inhibit metastasis of colon and melanoma cancers. The findings are published in the October 10, 2011 issue of Proceedings of the National Academy of Sciences.

Michael B. Dwinell, Ph.D., director of the Bobbie Nick Voss Laboratory and associate professor of microbiology and molecular genetics, is the lead author on the paper.

Chemokines and chemokine receptors are extensively involved in metastasis of 23 different forms of cancer. The chemokine referred to as CXCL12 is naturally expressed in the bone marrow, lungs and liver, all organs where cancer commonly metastasizes, but is often repressed in colon, breast and lung cancers.

In previous studies, researchers from the Dwinell laboratory had shown CXCL12 to reduce tumor growth and metastasis in colon and breast cancers. In those experiments, CXCL12 was engineered to produce the protein. However, for this study, researchers administered wild-type CXCL12 (naturally occurring CXCL12) or different oligomeric structures, either "monomer" (single) CXCL12 or a "dimer," a paired CXCL12 protein molecule and compared the results for both tumor growth and metastatic suppression.

CXCL12 proteins effectively blocked metastasis of the colon cancer and dramatically improved survival time, with the dimer showing effectiveness in blocking melanoma metastasis as well. Together with their prior results, the laboratory has shown that repression of native CXCL12 expression is a key signature in colon cancer whose impact on tumor malignancy can be reversed by administering the chemokine proteins. They also demonstrated that the single or paired proteins blocked metastasis while initiating unique biochemical signals through the receptor CXCR4.

"These data establish CXCL12 as a potential avenue for the next generation of biologic therapies that specifically target metastasis, which is key in cancer treatment and the improvement of survival rates" said Dr. Dwinell.


'/>"/>
Contact: Maureen Mack
mmack@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. Researchers design artificial cells that could power medical implants
3. Salk scientist Fred H. Gage to receive the Keio Medical Science Prize
4. New book dissects statistics for doctors and medical students
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. A card-swipe for medical tests
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
11. New book helps medical students master clinical skills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC , ... that the United States Patent and Trademark Office (USPTO) ... covers the linking of an iris image with a ... and represents the company,s 45 th issued patent. ... is very timely given the multi-modal biometric capabilities that ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... California (PRWEB) , ... April 27, 2017 , ... ... new infographic explaining why mass flow controllers based on capillary thermal mass flow ... industrial gas mass flow control applications. Over 80% of all industrial processes—such ...
(Date:4/27/2017)... -- Pendant Biosciences, Inc. (formerly Nanoferix, Inc.), a privately-held advanced ... technologies, today announced that it has been accepted into ... . Shawn Glinter , Founder ... are excited to become part of the JLABS @ ... to be the first Tennessee -based ...
(Date:4/26/2017)... ... April 26, 2017 , ... Led ... phase I clinical trials comes to Tampa, San Francisco and Boston in 2017. ... representing FDA regulated organizations such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular ...
(Date:4/26/2017)... ... April 26, 2017 , ... As ... conversations among healthcare industry stakeholders, the discussion surrounding the topic will continue at ... 15-18, 2017 in Los Angeles, Calif. Hosted by the Workgroup for Electronic Data ...
Breaking Biology Technology: