Navigation Links
Medical College of Wisconsin researchers show molecule inhibits metastasis
Date:10/10/2011

Researchers at the Medical College of Wisconsin have shown that a protein can inhibit metastasis of colon and melanoma cancers. The findings are published in the October 10, 2011 issue of Proceedings of the National Academy of Sciences.

Michael B. Dwinell, Ph.D., director of the Bobbie Nick Voss Laboratory and associate professor of microbiology and molecular genetics, is the lead author on the paper.

Chemokines and chemokine receptors are extensively involved in metastasis of 23 different forms of cancer. The chemokine referred to as CXCL12 is naturally expressed in the bone marrow, lungs and liver, all organs where cancer commonly metastasizes, but is often repressed in colon, breast and lung cancers.

In previous studies, researchers from the Dwinell laboratory had shown CXCL12 to reduce tumor growth and metastasis in colon and breast cancers. In those experiments, CXCL12 was engineered to produce the protein. However, for this study, researchers administered wild-type CXCL12 (naturally occurring CXCL12) or different oligomeric structures, either "monomer" (single) CXCL12 or a "dimer," a paired CXCL12 protein molecule and compared the results for both tumor growth and metastatic suppression.

CXCL12 proteins effectively blocked metastasis of the colon cancer and dramatically improved survival time, with the dimer showing effectiveness in blocking melanoma metastasis as well. Together with their prior results, the laboratory has shown that repression of native CXCL12 expression is a key signature in colon cancer whose impact on tumor malignancy can be reversed by administering the chemokine proteins. They also demonstrated that the single or paired proteins blocked metastasis while initiating unique biochemical signals through the receptor CXCR4.

"These data establish CXCL12 as a potential avenue for the next generation of biologic therapies that specifically target metastasis, which is key in cancer treatment and the improvement of survival rates" said Dr. Dwinell.


'/>"/>
Contact: Maureen Mack
mmack@mcw.edu
414-955-4744
Medical College of Wisconsin
Source:Eurekalert

Related biology news :

1. American College of Medical Genetics receives $13.5M NIH contract
2. Researchers design artificial cells that could power medical implants
3. Salk scientist Fred H. Gage to receive the Keio Medical Science Prize
4. New book dissects statistics for doctors and medical students
5. Supercomputer provides massive computational boost to biomedical research at TGen
6. A card-swipe for medical tests
7. Rhode Island Hospital simulation center examines benefits and applications of medical simulation
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. NC State finds new nanomaterial could be breakthrough for implantable medical devices
10. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
11. New book helps medical students master clinical skills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, ... of the Supplyframe Design Lab . Located in Pasadena, Calif., the Design ... of how hardware projects are designed, built and brought to market. , The ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology: