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Mediator in communication between neurons and muscle cells found
Date:10/22/2008

esearchers know LRP4's critical role, they will look in patient samples where they suspect they also will find mutant forms and autoantibodies to it as well, Dr. Zhang says. They'll also look to see if LRP4 has a role in later development and maintenance of the neuromuscular junction.

In research published in the Oct. 9 issue of Neuron, the same research team used the neuromuscular junction to identify Hsp90β as a stabilizing protein that helps receptors on muscle cells get and stay where needed to catch a neuron's signal. This process showed the need for teamwork as well since rapsyn, a protein responsible for anchoring the receptor, is oddly unstable. They showed Hsp90β gives rapsyn needed stability.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

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