Navigation Links
Media highlights in the March 1 issue of Biophysical Journal

The reductionist goal of cell biology is to explain cellular activities in physical-chemical terms. To do this, one needs to quantify molecular concentrations and aggregation states in living cells as they execute and regulate various complex processes. For a complex cellular activity like migration, which is characterized by highly localized, transient component processes, the need is for high resolution spatial maps is essential. The currently available techniques only measure protein concentration and aggregation either for the cell as a whole or for limited number of points at a relatively few time points, thus blurring both spatial and temporal information. The method described by Digman, et al. uses fluorescence fluctuations to map molecular interactions at each pixel of an image. The novelty of this technique, termed the N and B analysis, is that quantitative information about the number of molecules and their aggregation states are mapped pixel by pixel. This method is fast and can be applied to molecular signaling events to follow the aggregation states of receptors and downstream components as a function of time. Another advantage is that immobile or slowly moving features, like cell edges and borders as well as contributions from photobleaching are separated so that only the species that fluctuate more rapidly are analyzed. This technique is can be used with laser scanning microscopes and is a powerful, new tool for anyone interested in live cell imaging.


Contact: Ellen R. Weiss
Biophysical Society

Page: 1

Related biology news :

1. September Geology and GSA Today media highlights
2. Heart of Herschel to be presented to media
3. Last chance for media to register for ECCO 14 -- the European Cancer Conference
4. October Geology and GSA Today media highlights
5. Media highlights in the November issues of Biophysical Journal
6. November GEOLOGY and GSA TODAY Media Highlights
7. Nanotechnology and the media: The inside story
8. December GEOLOGY and GSA TODAY media highlights
9. Better protection for biomedial devices could result from Rutgers-Camden research
10. Media highlights in the Dec. 15 issue of Biophysical Journal
11. Immediate action needed to save corals from climate change
Post Your Comments:
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a United States multicenter, prospective clinical study that demonstrates the accuracy ... test capable of identifying clinically significant acute bacterial and viral respiratory tract ...
(Date:10/11/2017)... LINDA, CA (PRWEB) , ... October 11, 2017 ... ... to upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding ... (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... HILLS, Calif. , Oct. 11, 2017  SkylineDx today ... (ICR) and University of Leeds ... risk-stratify patients with multiple myeloma (MM), in a multi-centric Phase ... University of Leeds is the sponsor ... and ICR will perform the testing services to include high-risk ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
Breaking Biology Technology: