Navigation Links
Media highlights in the January issues of Biophysical Journal
Date:1/29/2008

laxation
Christoph P Riethmuller, University of Munster Hans Oberleithner, University of Munster Marianne Wilhelmi, University of Munster Jonas Franz, University of Munster Eberhard Schlatter, University of Munster Jens Klokkers, University of Munster Bayram Edemir, University of Munster
Keywords: AFM; Aquaporin; Elasticity; Epithelial cells; Force Mapping; Kidney

The study adds a biomechanical perspective to the knowledge of vesicle transport regulation. Shuttling vesicle-embedded proteins from cytosol to the plasma membrane is an essential process for living cells. Biochemists have discovered a high number of proteins that contribute to this intricate regulation mostly by monitoring their phosphorylation status. Likewise numerous biophysical studies have explored the mechanics of single motor proteins of the myosin, dynein and kinesin families involved.

Here, a biomechanical approach is taken, where in living cells the tension of the cytoskeletal network is monitored by atomic force microscopy. This network spans all cells and thereby constitutes a supramolecular (mesoscopic) stiffness of the cell body.

The idea of the authors was that vesicles, driven by motor proteins along a fiber, face a resistance of crossing fibers, which varies with the tension of this network. The experiments performed on rat kidney cells favor this view. The vesicle transport is accelerated when the network fibers relax. In simple words, a physically relaxed cell is doing much better in vesicle transport compared to a cell under tension. This finding indicates that intracellular vesicle trafficking has a strong biomechanical component.


'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
301-634-7176
Biophysical Society
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. February Geology and GSA Today media highlights
2. Media advisory -- 2008 Ocean Sciences Meeting
3. Oliguridylation-mediated histone mRNA decay
4. Immediate action needed to save corals from climate change
5. Media highlights in the Dec. 15 issue of Biophysical Journal
6. Better protection for biomedial devices could result from Rutgers-Camden research
7. December GEOLOGY and GSA TODAY media highlights
8. Nanotechnology and the media: The inside story
9. November GEOLOGY and GSA TODAY Media Highlights
10. Media highlights in the November issues of Biophysical Journal
11. October Geology and GSA Today media highlights
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2008)...ndia "Waterproof" versions of popular varieties o...bmergence, have passed tests in farmers, fields wi...ow close to official release by national and state...ia, where farmers suffer major crop losses because...ear. This is enough rice to feed 30 million people...
(Date:11/21/2008)...ed Professor, DSc Barbara Ann Halkier, Department ...of Life Sciences, University of Copenhagen, has be...e prestigious award for her excellent research int...tive substances in, for instance, plants. In part...athways, regulation and transport of glucosinolate...
(Date:11/21/2008)...CE, R.I. [Brown University] Although Americans ar...posure from everyday household products like bisph... women do not readily connect typical household pr... adverse health effects, according to research fro... Social Behavior . Brown University sociologist Ph...
(Date:11/20/2008)...periences Record Revenue Growth from Operations in...PRNewswire-FirstCall/ -- bioMETRX, Inc. (OTC Bulle...based finger recognition products, today announced...mber 30, 2008. , , -- Revenues for the thir...ncrease over second quarter revenues of $100,000. ...
Breaking Biology News(10 mins):From genes to farmers' fields 2From genes to farmers' fields 3The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen 2Household exposure to toxic chemicals lurks unrecognized, researchers find 2Household exposure to toxic chemicals lurks unrecognized, researchers find 3bioMETRX, Inc. Highlights 3rd Quarter 2008 Financial Results 2Hylands Cough and Cold Medicines Remain a Safe and Effective Option for Toddlers and Young Children 9783 1Hylands Cough and Cold Medicines Remain a Safe and Effective Option for Toddlers and Young Children 9783 2Statehouse Atrium to be Site for Childrens Dental Access Event Ohio Legislators to Mingle With Children and Dentists for This Free Care Event 21 9781 1Statehouse Atrium to be Site for Childrens Dental Access Event Ohio Legislators to Mingle With Children and Dentists for This Free Care Event 21 9781 2Barr Will Host Calendar 2007 and Fourth Quarter Earnings Conference Call on February 28 2008 2664 1Barr Will Host Calendar 2007 and Fourth Quarter Earnings Conference Call on February 28 2008 2664 2Barr Will Host Calendar 2007 and Fourth Quarter Earnings Conference Call on February 28 2008 2664 3Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV I HTLV II 2662 1Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV I HTLV II 2662 2Abbott Announces Approval of First Fully Automated Blood Screening Test for HTLV I HTLV II 2662 3
...ing a common ingredient in shampoo to paints and v...requently touched surfaces in public buildings tha...research conducted by a multi-state consortium of ...gh the website science-projects.com, 10 students f...d War II veterans and a retired railroader from Vi...
...t genetic resources ?"blue gold" on the internatio...d commercial exploitation, warns a new report from...te for Advanced Studies (UNU-IAS). , Increasingly ...ential medical and other uses, deep sea resources ...ecause of rapid advances in exploration technology...
...odification to an "ace" gene prediction program by...t. Louis now enables scientists to predict the ver... where the first splice occurs thereby defining th...e gene prediction software TWINSCAN is called N-SC...ence at Washington University in St. Louis, togeth...
...ew way to monitor the effects of climate change on...iversity. Researchers are using biomarkers in the ...er plants) to find out how their photosynthesis an...change over the last 50 years. , Using types of ep...om Professor Howard Griffiths, lab in Cambridge ha...
Other Biology News:Shampoo detergent added to paint makes surfaces self-sterilizing 2A Father’s Day Gift: Free DNA Paternity Testing 2A Father’s Day Gift: Free DNA Paternity Testing 3A Father’s Day Gift: Free DNA Paternity Testing 4A Father’s Day Gift: Free DNA Paternity Testing 5Modification of program enables prediction of gene transcription 2Modification of program enables prediction of gene transcription 3
(Date:11/21/2008)...hat it will dramatically outshine traditional comp...large databases, factoring large numbers, creating...ture of materials. , A quantum step in that dire... Stanford researchers who announced their success ...ing in the Ginzton Laboratory, they,ve employed ul...
(Date:11/21/2008)... MichBio, the association for,Michigan,s bioscien...essionals,and service providers to its fourth ann... the Rock Financial ShowPlace in Novi, MI. The Mi...higan bioscience industry professionals.,In addit...e 2009 Expo is,planned for November 17-18 at the ...
(Date:11/21/2008)...UCTURING ALTERNATIVES ONGOING , , VANCOUVER...aceuticals, Inc. (NASDAQ: ANPI , TSX: ANP), a gl...ompany, today announced that the Company had been ...nture Partners (New Leaf) that they had elected to...7, 2008. Angiotech had announced on September 22, ...
(Date:11/21/2008)... -- Gen-Probe,s (Nasdaq: GPRO ),CE-marked APTIM...ool to more,accurately detect high-risk human pap...with cervical cancer or precancerous lesions, acco...ic posters presented last week by,independent and...ence of the,European Research Organization on Gen...
Breaking Biology Technology:Stanford: Quantum computing spins closer 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 3Angiotech announces termination of note purchase agreement with Ares Management and New Leaf Venture Partners 2Angiotech announces termination of note purchase agreement with Ares Management and New Leaf Venture Partners 3Angiotech announces termination of note purchase agreement with Ares Management and New Leaf Venture Partners 4Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 2Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 3Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 4Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 5
... To complement the two- and four-port Ethernet ca...munications has released software for Apple G4 an...puter into one interface with more bandwidth. , ,T...it Ethernet cards for Apple Xserve and Power Mac p... G4, Windows and Linux. President Corky Seeber has...
...dical College of Wisconsin has implemented IBM s...computing infrastructure support system for proteo...enter JS20 the industrys first blade system based...ume globally in April 2004. The MCW is the initia... the JS20 running SUSE LINUX. Sequest is an applic...
...cent trade mission made clear that China represent.... But we also learned that Wisconsin companies do... must take important steps to protect their intell...n to China, we saw that significant counterfeiting...ses and the Chinese government to prevent it. The...
...nte Corporation , the financial technology subsidi...dnesday the signing of a definitive agreement to a.... , ,The privately held Kirchman Corporation is a ...vices to the banking industry. The Kirchman Corpor...te within the Metavante Financial Services Group. ...
Other Biology Technology:Small Tree boosts bandwidth for Apple G4 and G5 servers 2Medical College of Wisconsin enhances research with IBM Blade server 2Protecting your intellectual property in overseas markets 2Metavante acquires Florida banking corporation 2
Custom Human Cytokine Antibody Array, Choose from hundreds of proteins. from Raybiotech, Inc.
Human LAIR2 Biotinylated Affinity Purified PAb
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma.
PGF1α-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGF1α by GC- or LC-mass spectrometry.
Biology Products: