Navigation Links
Media highlights in the Dec. 15 issue of Biophysical Journal
Date:12/7/2007

Bethesda, MD - The December 15th issue of Biophysical Journal, published by the Biophysical Society, is now available online. Topics of interest include cardiac contraction, x-ray diffraction, DNA elasticity, optical trapping; single-molecule, ADP-bound cross-bridges; cooperativity, and sarcomere.

Volume 93, Issue 12, December 15, 2007


Effects of Sustained Length-Dependent Activation on In Situ Cross-Bridge Dynamics in Rat Hearts

James T Pearson, Monash University
Mikiyasu Shirai, Hiroshima International University
Hirotsugu Tsuchimochi, National Cardiovascular Center
Daryl O Schwenke, University of Otago
Takayuki Ishida, Hiroshima International University
Kenji Kangawa, National Cardiovascular Center
Hiroyuki Suga, National Cardiovascular Center
Naoto Yagi, JASRI, SPring-8

Keywords: cardiac contraction; interfilament spacing; myosin cross-bridges; x-ray diffraction

The intrinsic ability of the heart to adjust the strength of its contractions to the amount of blood filling the heart has been the subject of much interest, and even more speculation. This fundamental mechanism that regulates heart work with every single beat is vital to our existence. Breakdown of this cellular mechanism of control leads to lung congestion and heart failure. The force of contraction is essentially determined by the interactions of two large proteins, actin and myosin. Our group now demonstrates that the cellular mechanism involves sensing the spacing between the filaments of myosin and actin as the heart fills with blood. The strength of contraction is then adjusted according to the stretch of the proteins within the muscle fibres. We have been able to do this by rapidly analyzing the scatter of pulses of synchrotron x-ray radiation off the muscle fibres of the intact heart as it contracts spontaneously. Many other proteins are known to be associated with actin and my
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
301-634-7176
Biophysical Society
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. September Geology and GSA Today media highlights
2. Heart of Herschel to be presented to media
3. Last chance for media to register for ECCO 14 -- the European Cancer Conference
4. October Geology and GSA Today media highlights
5. Media highlights in the November issues of Biophysical Journal
6. November GEOLOGY and GSA TODAY Media Highlights
7. Nanotechnology and the media: The inside story
8. December GEOLOGY and GSA TODAY media highlights
9. Better protection for biomedial devices could result from Rutgers-Camden research
10. Highlights from the September 2007 Journal of the American Dietetic Association
11. AGU journal highlights -- Sept. 6, 2007

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2009)...eavy traffic corridors in the cities of Long Beach...roportion of preventable childhood asthma, and the...n the disease has likely been underestimated, acco... California (USC). , The study, which appears i...blic Health , estimated that nine percent of all c...
(Date:11/4/2009)...ancouver, BC - Lowly bacteria, it turns out, hold ...turing plants around the world clean up toxic wast..., specifically RDX, were invented back in World Wa...decades. These high-energy compounds are often us...ful version of TNT. , But with increased knowl...
(Date:11/4/2009)...he University of Oklahoma at Norman has received m...funding agencies as part of the federal stimulus p...ng received by OU researchers to $23 million. Thi...search ranging from archaeology to weather. , "T...atic approach to matching areasof scholarly excell...
Breaking Biology News(10 mins):USC study finds big air pollution impacts on local communities 2Genomic research will enable greener cleanup of military explosive test sites 2OU achieves $10 million in stimulus grants for 33 projects on the Norman campus 2OU achieves $10 million in stimulus grants for 33 projects on the Norman campus 3New Medical Imaging Organization Launched to Represent Industry Personnel and Diagnostic Clinics 51599 1New Medical Imaging Organization Launched to Represent Industry Personnel and Diagnostic Clinics 51599 2Inspiration Biopharmaceuticals Presents Safety Data on IB1001 a Novel Recombinant Factor IX for the Treatment of Hemophilia at the International Soci 13015 1Inspiration Biopharmaceuticals Presents Safety Data on IB1001 a Novel Recombinant Factor IX for the Treatment of Hemophilia at the International Soci 13015 2JBFCS Surpasses Fundraising Goal For Hudson Valley Bike Ride Despite Difficult Financial Times 51594 1JBFCS Surpasses Fundraising Goal For Hudson Valley Bike Ride Despite Difficult Financial Times 51594 2
...a Tech researchers in computer science and biology...X, to create models and algorithms that make it po... leading to cell division. They have demonstrated ...orithms provide powerful tools for studying the co...ologist John Tyson, who studies the cell cycle, is...
...ity of Newcastle researcher Kathryn Skelding, fund...ralytics Ltd, has been working on a new treatment ...improvement on conventional chemotherapy and radia...ells. , "In theory, the virus is able to selective...er cells, including breast cancers, whilst leaving...
...ent, chronic pain has risen dramatically among ful...ers today opt to go to their jobs rather than call...sm ?a negative impact on work despite being physic...y, are from a 2006 national survey conducted by Ha....painandwork.com ), sponsored by PriCaraƔ, Unit of...
Other Biology News:Virginia Tech's System X supercomputer provides super tool for simulation of cell division 2Virginia Tech's System X supercomputer provides super tool for simulation of cell division 3Common cold virus may kill breast cancer cells 2Chronic pain up almost 40 percent among US workers in past decade 2
(Date:11/6/2009)...ONTO, Nov. 6 /PRNewswire-FirstCall/ - Microbix Bio...it has re-filed the Form 52-109F1 Certification of...tive Officer and James Long, the Chief Financial O...y 12, 2009 in connection with the annual audited f...0, 2008. ,, The Company initially filed the ann...
(Date:11/6/2009)...ORA, Ontario, Nov. 6 Hel... HXBPF) today announced that John Docherty, presid...erriman Curhan Ford,s 6th annual Investor Summit o...l in New York City. Mr. Docherty will provide an ...ent programs L-DOS47 and Topical Interferon Alpha-...
(Date:11/6/2009)... VIENNA, Austria, November 6 EUCOD...manufacturing, and marketing enzymes for the,chemi...nto a research,agreement with Bio Sidus, the leadi..., The agreement gives EUCODIS Bioscience exc...est - to Bio Sidus, proprietary collection of,psyc...
(Date:11/6/2009)...ING VALLEY, Calif., Nov. 6 Calbiot... a Small Business Innovative Research (SBIR) Phase...Material command. Under terms of the agreement, Ca...SRs) for the diagnosis of Dengue virus. ,, D...resents a major threat to military forces deployed...
Breaking Biology Technology:Helix BioPharma to Present at Merriman Curhan Ford's Investor Summit 2009 on November 10th 2Helix BioPharma to Present at Merriman Curhan Ford's Investor Summit 2009 on November 10th 3EUCODIS Bioscience to Explore Novel Enzymatic Activities in Antarctic Bacteria Library From Bio Sidus 2Calbiotech Awarded U.S. Army Phase I SBIR Research Contract to Develop Analyte Specific Reagents for the Diagnosis of Dengue Fever Virus 2
...tober 27 Stallergenes has,just obtained authoriza...ng,a phase III clinical trial in the United States...gic rhinoconjunctivitis to grass pollens in adults...in 450 American patients,during the 2009 pollen se...e of the product in adults and to support the appl...
...Oct. 27 Dr. Annie De Groot, CEO of,EpiVax, is the...gs about,the activation of natural regulatory T ce... or "Tregitopes." These findings were published in... medical journal published by,the American Society...chel Caspi of the National Institutes,of Health (N...
... Edmontonians magazine is partnering with ...chnology community and its companies and prove how...ct businesses. , Edmonton...onthly business publication serving the Capital Re...t, Innovation, Ingenuity project with the goal of...
Other Biology Technology:Stallergenes: Launch of a Phase III Clinical Trial in Adults for Oralair(R) Grasses in the United States Operating Income Expected to Remain Stable in 2009 2Stallergenes: Launch of a Phase III Clinical Trial in Adults for Oralair(R) Grasses in the United States Operating Income Expected to Remain Stable in 2009 3Publication on 'Tregitopes' in Blood Journal of October 2008 2Edmonton's Technology Community: Using Social Media to Raise Awareness 2
Rabbit Anti-ZNF261 Polyclonal Antibody, Unconjugated from Abcam
Psp1406 I from Takara Mirus Bio
Mouse Anti-Integrin alpha M Monoclonal Antibody, Unconjugated, Clone ICRF 44 from Novus Biologicals
Rabbit Anti-CKB, N-Terminus Polyclonal Antibody, Unconjugated from Abgent
Biology Products: