Navigation Links
Media highlights for February in Biophysical Journal
Date:3/10/2008

Bethesda, MD A new and notable article entitled Passage Times for Polymer Translocation Pulled through a Narrow Pore appears in Volume 94, Issue 5, of the Biophysical Journal, which is available online.

Passage Times for Polymer Translocation Pulled through a Narrow Pore

When polymeric molecules squeeze through a nanometer-sized pore in membranes, in a process known as translocation, they leave a distinct signature at the pore. Present-day techniques can exploit translocation to recognize individual polymeric molecules by analyzing these signatures. Interestingly, one encounters translocation more frequently as a serious bottleneck: the prospect of polymeric molecules passing through nanometer-sized pores in inter/intra-cellular membranes hinders efficient delivery of drug molecules to their activation sites, and of healthy gene fragments to their target sites in gene therapy.

The physics of translocation is complex since our intuition, based on the macroscopic world, fails: concepts, such as "translocation is slow because the pore resists the passage of the molecule through friction", cannot be trusted at the nanoscale. Instead, other concepts like fluctuations in translocation dynamics at a molecular level are much more important.

Recently, we have made a significant breakthrough in understanding the physics of translocation. Starting from the microscopic dynamics of the polymeric molecule, we showed that its translocation behavior is strongly dominated by "memory effects" in the molecule. Each translocative step forward for the molecule through the pore generates a restoring tension that makes a following backward step through the pore very likely: as if the molecule remembers that it took a step forward, and it wants to return to the previous step. Consequently, every part of the molecule passes back and forth through the pore many, many times. Two most striking consequences of these wild fluctuations are that
'/>"/>

Contact: Ellen R. Weiss
eweiss@biophysics.org
301-634-7176
Biophysical Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2008 Ocean Sciences Meeting -- media advisory 2
2. March GEOLOGY and GSA TODAY media highlights
3. Media highlights in the March 1 issue of Biophysical Journal
4. Priming scientists for successful media interviews
5. Media highlights in the January issues of Biophysical Journal
6. February Geology and GSA Today media highlights
7. Media advisory -- 2008 Ocean Sciences Meeting
8. Oliguridylation-mediated histone mRNA decay
9. Immediate action needed to save corals from climate change
10. Media highlights in the Dec. 15 issue of Biophysical Journal
11. Better protection for biomedial devices could result from Rutgers-Camden research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2015)... June 26, 2015 ATL Technology, LLC, a top ... specialties in single use solutions, headquartered in Springville, ... (a California corporation with locations in ... San Jose, Costa Rica ). This acquisition ... with ATL Technology,s existing facility in ...
(Date:6/25/2015)... 2015  TAKE Solutions Ltd., a global business technology ... States Patent and Trademark Office (USPTO) for its "Method ... Solutions, Clinical Accelerators to reduce the time taken to ... standardization without the accelerators), thus reducing time to market. ... At the heart of the patented Clinical Data Standardization ...
(Date:6/24/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Sharp has selected its industry-leading Natural ... its latest flagship smartphone device, the AQUOS ZETA ... shipments of its fingerprint ID sensor technology, this ... and leadership in the biometrics market through its ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2TAKE Solutions Awarded Patent By USPTO 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... Research (LICR) and the University of California, San Diego ... identifying functional elements in the human genome, according to ... , While the DNA sequence can identify genes (the ... fundamental questions of 'how,' 'when' and 'where' gene products ...
... be caused by hypoglycemic coma actually occurs when glucose is ... rodents led by researchers at the San Francisco VA Medical ... and may be of clinical significance for the treatment of ... cannot be immediately extrapolated to humans. , Insulin is ...
... over a scientific paper that is putting Korea's scientific ... pitted a young Korean doctor, Jeong Hwan Kim, against ... the most powerful players in the country's struggle for ... threatening to disrupt Korea's efforts to recover scientific credibility ...
Cached Biology News:Beyond the DNA: Chemical signatures reveal genetic switches in the genome 2Glucose triggers brain cell death in rats after hypoglycemic coma 2Glucose triggers brain cell death in rats after hypoglycemic coma 3Row over study puts Korea's scientific community under scrutiny again 2
(Date:7/3/2015)... Forskare kan ansöka ... http://www.openinnovationinscience.at till det återkommande utbildningsprogrammet "Lab ... i Wien .  ... forskare och vetenskapsmän som genomfördes av Ludwig ... utmaningar bristen på incitament för att undersöka ...
(Date:7/2/2015)... GLEN ELLYN, Ill. , July 2, 2015 /PRNewswire-USNewswire/ ... and Colton Eakins are gaining invaluable real-world ... Institute of Technology this summer. The students ... Dr. Jeff Wereszczynski,s research group at IIT. ... Professors Dr. Tom Carter , Physics; Dr. ...
(Date:7/1/2015)... Costa Mesa, CA (PRWEB) , ... July 01, 2015 , ... ... and traumatic brain injury (TBI) using single photon emission computed tomography (SPECT) ... Columbia. The study, which examined over 20,000 brain scans and is believed to ...
(Date:7/1/2015)... , July 1, 2015   Neuraltus ... the development of groundbreaking drugs to treat neurodegenerative ... today that Robert G. Miller , M.D., Director ... Sutter Health,s California Pacific Medical Center in San Francisco, ... Association for $1.5 million to help fund a ...
Breaking Biology Technology:Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3COD Students Participate in Prestigious Summer Internships 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4
... to Expand Global Reach in Pioneering Field, ... today announced the acquisition of an ownership interest ... and services for,flexible, or adaptive, clinical trials. Headquartered ... has designed and implemented 80,adaptive programs over the ...
... DIEGO, Sept. 10 /PRNewswire-FirstCall/ - MIGENIX Inc.,(TSX: ... drugs for infectious,diseases will present results of ... at the 14th International Symposium on Hepatitis ... being held September 9th to 13th 2007,in ...
... Sept. 10 Pressure,BioSciences, Inc. (Nasdaq: PBIO ... of pressure cycling technology (PCT) in studies,to (1) ... of colon cancer, and (3) detect proteins associated ... in three presentations at the 29th,Annual Meeting of ...
Cached Biology Technology:United BioSource Acquires Interest in Leading Adaptive Design Technology Service Provider 2MIGENIX to Present Positive Celgosivir Viral Resistance Data at International HCV Meeting 2MIGENIX to Present Positive Celgosivir Viral Resistance Data at International HCV Meeting 3Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Society's 29th Annual Meeting 2Three Studies by Independent Scientists Highlighting Pressure Cycling Technology (PCT) to be Presented this Week at the British Mass Spectrometry Society's 29th Annual Meeting 3
... enhance luminescent signals and have low ... (or medium binding) polystyrene surface is ... through passive interactions,• Is suitable primarily ... such as antibodies, that have large ...
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... washing needs in both the 384-well format and ... an excellent solution for a variety applications in ... or Lead Optimization) and Research. , Unmatched ... set a standard for ultra-fast washing in both ...
... MULTI-FUN Incubator is a compact benchtop ... a microprocessor controller with a large ... and agitation speed. Air circulation inside ... incubator. Temperature can be easily calibrated ...
Biology Products: