Navigation Links
Mechanisms of wound healing are clarified in MBL zebrafish study
Date:10/29/2013

WOODS HOLE, Mass. A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. These cells fill the wound in and help prevent infection while new skin cells regenerate.

How do these neighboring skin cells know which way to migrate? What directional cues are they receiving from the wound site? A new paper by Mark Messerli and David Graham of the MBL's Eugene Bell Center for Regenerative Biology and Tissue Engineering clarifies the role of calcium signaling in this medically significant communication between skin cells.

Messerli and Graham conducted the study using zebrafish skin cells, which migrate much faster than human cells. "Fish have to heal quickly," Messerli says. "They are surrounded by microbes and fungi in the water. They are constantly losing scales, which generates a wound. So the wound has to be healed in the epidermis first and then a new scale has to be built. Fish skin cells (keratinocytes) migrate five times faster at room temperature than mammalian cells do at 37 degrees C. So it is very easy to track and follow their migratory paths in a short period of time. "

The study brought fresh insights on the role of calcium signaling in inducing cellular organization and directed migration of skin cells. "When we started this study, we were looking at calcium signaling at the single-cell level, which is how it has been looked at for decades. How do single cells see injury?" Messerli says.

To their surprise, by the end of the study they were looking at the calcium signals not just in single cells but in sheets of cells that surround wounds. "The periphery of the wound itself appears to form a graded calcium signal that could direct migration and growth toward the center of the wound. This is what we are looking at now," Messerli says.

The team's approach was to use advanced microscopy to monitor cellular calcium signals and mol
'/>"/>

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists at Mainz University decode mechanisms of cell orientation in the brain
2. Evolution of diverse sex-determining mechanisms in mammals
3. Researchers uncover cellular mechanisms for attention in the brain
4. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
5. New study identifies unique mechanisms of antibiotic resistance
6. Series of studies first to examine acupunctures mechanisms of action
7. Whole genome sequencing of wild rice reveals the mechanisms underlying oryza genome evolution
8. Antarctic and Arctic insects use different genetic mechanisms to cope with lack of water
9. Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified
10. 1 disease, 2 mechanisms
11. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mechanisms of wound healing are clarified in MBL zebrafish study
(Date:10/16/2014)... land managers have a new synthesis of recent research ... (MMC) forests in the two states. , The ... Oregon and Washington: A Synthesis of the Relevant Biophysical ... technical report published by the U.S. Forest Service,s Pacific ... request from managers for a synthesis of the large ...
(Date:10/16/2014)... – Post-menopausal women experienced improvements in vaginal atrophy, ... genital bleeding, after 12 weeks of daily 10 ... germ-based nutritional supplement previously shown to help relieve ... pilot study reported in a poster at the ... , "These data documented improved vaginal epithelium, ...
(Date:10/15/2014)... Life, is a non-traditional biophysics textbook and it describes ... a journey of discovery into biological systems and provides ... regulation. It is about how our genes make proteins ... billions of cells in an organism. It quantifies the ... which can be found on both large and small ...
Breaking Biology News(10 mins):New report synthesizes best available science on management of moist mixed-conifer forests 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2New book about life as seen from physics 2
... measured in a simple blood test may be a new ... asthma, Yale School of Medicine researchers report today in the ... YKL-40, brings investigators one step closer to a treatment for ... the disease that is difficult to treat, the researchers say. ...
... MAA new Brandeis University study of twins shows that ... hearing loss that often appears in late middle age. ... examined genetic and environmental factors affecting hearing loss in ... research confirms the importance of genetic factors in age-associated ...
... as well as snow fields and glaciers are the ... human livelihoods. Continuous observations are crucial to manage ... the environment and also to provide crucial forecasting services ... These tasks are routinely undertaken by the National Hydrological ...
Cached Biology News:Yale discovery suggests protein may play a role in severe asthma 2Space technology put into service for global water resources observations 2
(Date:10/20/2014)... 20, 2014 Mapp Biopharmaceutical,s valiant effort ... therapeutic to fight the Ebola outbreak will make ... the production of pharmaceuticals can be, according to ... that while some may be taken aback by ... with industry knowledge are well aware of the ...
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
(Date:10/20/2014)... Oct. 20, 2014 PureTech , a ... big healthcare problems, announced today the closing of ... participation from Invesco Perpetual, a $120 Billion group ... drive PureTech,s existing pipeline forward and to advance ... the scientific creativity to really go for the ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Vical Incorporated (Nasdaq:,VICL) and AnGes MG, Inc., have ... interest to license the development and marketing,rights for ... AnGes. AnGes,plans to conduct due diligence on the ... negotiate terms and conditions potentially leading,to a license, ...
... Includes Isilon Customer the Broad Institute of MIT and ... ... SEATTLE, Oct. 7 Isilon(R) Systems (Nasdaq:,ISLN), the leader in ... will address the growing data storage,challenges facing life science research ...
... chemistry to the ... of chemists among the goals, BUDAPEST, Hungary, LONDON ... that it has signed agreements with a,number of academic ... San Francisco, Boston University, Temple,University and the University of ...
Cached Biology Technology:Vical and AnGes MG Sign Letter of Intent for Pandemic Influenza Program 2Isilon CTO Addresses Life Science Data Storage Challenges at Harvard Medical School's BioMedical HPC Leadership Summit 2Isilon CTO Addresses Life Science Data Storage Challenges at Harvard Medical School's BioMedical HPC Leadership Summit 3ThalesNano, Inc. Forms Collaborations with Leading US Universities based on the Award Winning H-Cube(R) and H-Cube Midi(TM) 2
Rat monoclonal to UGGT ( Abpromise for all tested applications)....
... anti-phospho-FAK (Ser843) Immunogen: ... region encompassing the human, mouse, and ... Accession Number: NM_153831 ... evaluated by immunoblot. ...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
Rabbit polyclonal to Quinolinic acid ( Abpromise for all tested applications). Antigen: Synthetic quinolinic acid conjugated to bovine serum albumin....
Biology Products: