Navigation Links
Mechanisms of wound healing are clarified in MBL zebrafish study
Date:10/29/2013

WOODS HOLE, Mass. A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. These cells fill the wound in and help prevent infection while new skin cells regenerate.

How do these neighboring skin cells know which way to migrate? What directional cues are they receiving from the wound site? A new paper by Mark Messerli and David Graham of the MBL's Eugene Bell Center for Regenerative Biology and Tissue Engineering clarifies the role of calcium signaling in this medically significant communication between skin cells.

Messerli and Graham conducted the study using zebrafish skin cells, which migrate much faster than human cells. "Fish have to heal quickly," Messerli says. "They are surrounded by microbes and fungi in the water. They are constantly losing scales, which generates a wound. So the wound has to be healed in the epidermis first and then a new scale has to be built. Fish skin cells (keratinocytes) migrate five times faster at room temperature than mammalian cells do at 37 degrees C. So it is very easy to track and follow their migratory paths in a short period of time. "

The study brought fresh insights on the role of calcium signaling in inducing cellular organization and directed migration of skin cells. "When we started this study, we were looking at calcium signaling at the single-cell level, which is how it has been looked at for decades. How do single cells see injury?" Messerli says.

To their surprise, by the end of the study they were looking at the calcium signals not just in single cells but in sheets of cells that surround wounds. "The periphery of the wound itself appears to form a graded calcium signal that could direct migration and growth toward the center of the wound. This is what we are looking at now," Messerli says.

The team's approach was to use advanced microscopy to monitor cellular calcium signals and mol
'/>"/>

Contact: Diana Kenney
dkenney@mbl.edu
508-289-7139
Marine Biological Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scientists at Mainz University decode mechanisms of cell orientation in the brain
2. Evolution of diverse sex-determining mechanisms in mammals
3. Researchers uncover cellular mechanisms for attention in the brain
4. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
5. New study identifies unique mechanisms of antibiotic resistance
6. Series of studies first to examine acupunctures mechanisms of action
7. Whole genome sequencing of wild rice reveals the mechanisms underlying oryza genome evolution
8. Antarctic and Arctic insects use different genetic mechanisms to cope with lack of water
9. Mechanisms regulating inflammation associated with type 2 diabetes, cancer identified
10. 1 disease, 2 mechanisms
11. Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mechanisms of wound healing are clarified in MBL zebrafish study
(Date:5/14/2015)... , May 14, 2015  Verificient ... identity verification and online remote proctoring, announced ... software-as-a-service (SaaS) company and creator of the ... of the two companies will benefit from ... Canvas. As a fully integrated ...
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... study, scientists sampled the presence of 20 species of ... in the Adirondack Park. Calculating their occurrence at increasing ... are 36 percent more likely to occur near the ... that "human-sensitive" species were 26 percent less likely. Beyond ...
... of Nottingham has been used in a breakthrough study ... fully functioning fetal heart. The abdominal fetal ECG ... of Electrical and Electronic Engineering and on commercial sale ... company Monica Healthcare Ltd, has been used to observe ...
... to replace artificial preservatives in bread, making it tastier., ... mould fermented in sourdough bread, Michael Ganzle, professor and ... of Agricultural, Food and Nutritional Science and fellow researchers ... keep bread fresh without changing its flavour. Preservatives ...
Cached Biology News:WCS Adirondack Park study shows exurban residences impact bird communities up to 200 meters away 2WCS Adirondack Park study shows exurban residences impact bird communities up to 200 meters away 3Nottingham technology in heart development breakthrough 2Nottingham technology in heart development breakthrough 3Nottingham technology in heart development breakthrough 4
(Date:5/26/2015)... China , May 26, 2015 Tianyin ... company that specializes in the patented biopharmaceutical, modernized traditional ... (API), announced that the Company,s Annual Meeting of Shareholders ... scheduled to be held at the Company,s office located ... conference call, at 9:00 AM (local time in ...
(Date:5/26/2015)... May 26, 2015  A simple blood test developed ... to detect early Alzheimer,s disease is a step closer ... Detailed standardized guidelines that are needed before a blood ... in Alzheimer,s & Dementia . The guidelines establish ... working group that includes UNT Health Science Center. ...
(Date:5/26/2015)... Mr. Kevin Xu , President of MEBO International, on ... and President Bill Clinton for their sympathy and ... Rongxiang Xu , Kevin,s father. As a ... Dr. Xu,s commitment to the advancement of science and his ... be forgotten. As a renowned life scientist, Dr. Xu devoted ...
(Date:5/26/2015)... 26, 2015  AbbVie (NYSE: ABBV ), ... has completed the acquisition of Pharmacyclics, Inc. enhancing ... is a leader in the hematological oncology market ... treat hematological cancers, a $24 billion global market. ... AbbVie,s broad late-stage oncology pipeline, has the potential ...
Breaking Biology Technology:TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2Dr. Rongxiang Xu, Beyond A Legend 2AbbVie Completes Acquisition of Pharmacyclics 2AbbVie Completes Acquisition of Pharmacyclics 3AbbVie Completes Acquisition of Pharmacyclics 4AbbVie Completes Acquisition of Pharmacyclics 5AbbVie Completes Acquisition of Pharmacyclics 6
... In its anniversary year joimax® presents numerous ... opening up the series of the big autumn congresses ... presents the now complete product range for endoscopic spinal ... new Multiuse-Set comprises instruments for endoscopic facet joint denervation ...
... -- Third ocular product partnered with ... Oxford BioMedica plc ("Oxford BioMedica" or "the Company") (LSE: ... the US Food and Drug Administration (FDA) has approved ... I/IIa clinical development of UshStat ® , a novel ...
... Sutro Biopharma, a biopharmaceutical company developing novel ... today announced that the company,s proprietary biochemical protein ... of novel protein therapeutics will be presented at ... Trevor Hallam, Ph.D., chief scientific officer of Sutro, ...
Cached Biology Technology:joimax® Launches Numerous Innovations at EuroSpine Milan From 19 To 21 October 2011 2Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 2Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 3Oxford BioMedica Announces US IND Approval for Novel Ocular Product in Usher Syndrome Type 1B 4Sutro Biopharma to Present its Biochemical Protein Synthesis Technology at BioProduction Conference 2011 in Berlin 2