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Mechanisms of juvenile hormone action in insects could help fine tune pesticides
Date:12/27/2010

Just as raging hormones are part of the process of a child's maturation through the teen years to adulthood, juvenile hormones, a group of insect isoprenoids, play an important role as butterflies, fruit flies and mosquitoes transform their body structures as they molt from larva to pupa and then adults.

Unlike humans, in insects the juvenile hormone inhibits development of adult characteristics until the insects reach a proper stage. Juvenile hormones also play a prominent role in regulating reproductive maturation in adult insects and synthetic juvenile hormone mimics have been widely used as pesticides for mosquito controls.

Virginia Tech researchers have discovered an important step in the activation of juvenile hormone target genes. "Understanding the molecular details in the juvenile hormone signaling may lead to discovery of novel chemicals that target mosquitoes with more selectivity," said Jinsong Zhu, assistant professor of biochemistry with the Fralin Life Science Institute at Virginia Tech.

The research is reported in the early online edition of the Proceedings of the National Academy of Sciences the week of Dec. 27.

"The secretion of juvenile hormone is drastically reduced in the final larval stage, as a result of which the larva is transformed into a pupa. While an insect protein, Methoprene-tolerant (Met), has been postulated as the top candidate for juvenile hormone receptor, it remains unclear how this protein is activated by juvenile hormone," said Zhu.

He and his group believe that studying the hormone-regulated reproduction have a better chance of elucidating the molecular action of juvenile hormones. They discovered a protein partner for Met in the yellow fever mosquito Aedes aegypti. This protein, named FISC, forms a complex with Met when juvenile hormone is present. Binding of these two proteins to the regulatory regions of some juvenile hormone target genes is closely correlated with t
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Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

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