Navigation Links
Mechanisms of juvenile hormone action in insects could help fine tune pesticides
Date:12/27/2010

Just as raging hormones are part of the process of a child's maturation through the teen years to adulthood, juvenile hormones, a group of insect isoprenoids, play an important role as butterflies, fruit flies and mosquitoes transform their body structures as they molt from larva to pupa and then adults.

Unlike humans, in insects the juvenile hormone inhibits development of adult characteristics until the insects reach a proper stage. Juvenile hormones also play a prominent role in regulating reproductive maturation in adult insects and synthetic juvenile hormone mimics have been widely used as pesticides for mosquito controls.

Virginia Tech researchers have discovered an important step in the activation of juvenile hormone target genes. "Understanding the molecular details in the juvenile hormone signaling may lead to discovery of novel chemicals that target mosquitoes with more selectivity," said Jinsong Zhu, assistant professor of biochemistry with the Fralin Life Science Institute at Virginia Tech.

The research is reported in the early online edition of the Proceedings of the National Academy of Sciences the week of Dec. 27.

"The secretion of juvenile hormone is drastically reduced in the final larval stage, as a result of which the larva is transformed into a pupa. While an insect protein, Methoprene-tolerant (Met), has been postulated as the top candidate for juvenile hormone receptor, it remains unclear how this protein is activated by juvenile hormone," said Zhu.

He and his group believe that studying the hormone-regulated reproduction have a better chance of elucidating the molecular action of juvenile hormones. They discovered a protein partner for Met in the yellow fever mosquito Aedes aegypti. This protein, named FISC, forms a complex with Met when juvenile hormone is present. Binding of these two proteins to the regulatory regions of some juvenile hormone target genes is closely correlated with the expression levels of those target genes in the newly emerged adult mosquitoes. Reducing the protein levels of Met or FISC by genetic approaches leads to dampened expression of the juvenile hormone target genes, and decreased egg production after the female mosquitoes take a blood meal.

The study by Zhu's group clearly demonstrates that formation of Met-FISC complex is a critical step in juvenile hormone signaling pathway. Evidence presented in the Proceedings of the National Academy of Sciences paper also suggests that fruit flies use the same mechanism in mediating juvenile hormone responses during molting.

Zhu is now collaborating with Professor David Bevan's group in the biochemistry department to analyze the structure-function relationship of the Met protein.


'/>"/>

Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Related biology news :

1. The most aggressive forms of breast cancer elude cellular control mechanisms in order to expand
2. New book reviews mechanisms of T-cell and B-cell activation
3. Squid studies provide valuable insights into hearing mechanisms
4. Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
5. Keystone Symposia to hold conference in Seattle on immunological mechanisms of vaccination
6. New mechanisms of tumor resistance to targeted therapy in lung cancer are discovered
7. VIB and UGent researchers identify key mechanisms of cell division in plants
8. Seeing how evolutionary mechanisms yield biological diversity
9. IUPUI researchers tackle protein mechanisms behind limb regeneration
10. New research into the mechanisms of gene regulation
11. UT Southwestern researchers examine mechanisms that help cancer cells proliferate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... Annual Report on Form 10-K on Thursday April 13, 2017 with ... ... Relations section of the Company,s website at http://www.nxt-id.com  under "SEC ... . 2016 Year Highlights: Acquisition ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
Breaking Biology Technology: