Navigation Links
Mechanisms involved in resistance to the bacteria Salmonella studied in a Ph.D. thesis

This press release is available in Spanish.

In their natural environment bacteria develop by forming communities of micro-organisms called biofilms that afford them greater resistance. These biofilms on farms and premises where food is processed lead to considerable economic losses besides being a potential source of contamination and transmission of the pathogen. In her PhD thesis,Violeta Zorraquino-Salvo has studied a specific protein type that activates the formation of biofilm in Salmonella and regulates bacterial motility. "Having a better idea of the mechanisms involved in these processes will help to design new, more effective strategies for preventing the formation of biofilm and its potential harm in the clinical, food and industrial ambit," points out the researcher.

Two decades ago it was discovered that a small molecule (the so-called c-di-GMP) could on its own hamper motility and activate the formation of biofilm. "This molecule is part of a signal transduction system: there are different sensory membranes on the membrane of the bacteria that pick up stimuli from the outside and transduce them into different intracellular levels of c-di-GMP, thus regulating different biological processes like biofilm formation. "In the first part of her thesis Zorraquino removed all the sensory proteins from the Salmonella's genome."We created a mutant Salmonella incapable of picking up stimuli from the medium in which it lives and therefore of producing biofilm under any circumstances. "After that, each sensory protein was inserted one by one to be able to analyse, under different ambient conditions, how each one contributed to the formation of biofilm. "We showed that under each condition tested, only some proteins are active, so each one is most likely responsible for the formation of biofilm whena given condition is present."

These results have enabled researchers to get a better idea about the mechanism by which Salmonella activates the formation of biofilm. "We have generated new knowledge that could be used to design new strategies to help to prevent the formation of biofilm in our factories and on our farms," as Violeta Zorraquino pointed out.

Bacterial motility

The second part of her research focussed on studying the effect of the same molecule (c-di-GMP) in another of Salmonella's biological processes: bacterial motility.A bacterium is capable of moving freely in a liquid medium by rotating its flagella, and when it reaches a suitable surface, it sticks to it and begins to create the biofilm."There is an intervening stepbetween being motile and sticking to a surfacein which the bacterium has to stop the rotation of its flagella completely. We have discovered what is responsible for this intervening step: cellulose, which is a component of biofilm, and the synthesis of which is activated in the presence of the c-di-GMP molecule."


Contact: Oihane Lakar Iraizoz
Elhuyar Fundazioa

Related biology news :

1. FASEB SRC announces: Molecular Mechanisms & Physiological Consequences of Protein Aggregation
2. FASEB SRC announces conference registration open for: Neural Mechanisms in Cardiovascular Regulation
3. FASEB SRC announces conference registration open for: Mechanisms in Plant Development Conference
4. X-rays reveal the self-defence mechanisms of bacteria
5. Mechanisms for a beneficial effect of moderate alcohol consumption on osteoporosis in women
6. Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body
7. Force of nature: Defining the mechanical mechanisms in living cells
8. Symposium: Protein-Folding Diseases: Models & Mechanisms
9. Discovery of mechanisms predicting response to new treatments in colon cancer
10. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
11. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
Post Your Comments:
(Date:10/29/2015)... Oct. 29, 2015 Daon, a global leader ... has released a new version of its IdentityX ... North America have already installed IdentityX ... includes a FIDO UAF certified server component ... to activate FIDO features. These customers include some of ...
(Date:10/27/2015)... YORK , Oct. 27, 2015 In ... major issues of concern for various industry verticals such ... is due to the growing demand for secure & ... in various ,sectors, such as hacking of bank accounts, ... for electronic equipment such as PC,s, laptops, and smartphones ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... 01, 2015 , ... Matthew “Tex” VerMilyea, PhD, HCLD, has joined Texas Fertility ... all IVF lab procedures as well as continue his research efforts into the emerging ... to Auckland, New Zealand to bring home a High Complexity Clinical Laboratory Director named ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... join physicians, aesthetic practitioners and aesthetics professionals from Central America and abroad for ... held in Panama City, Panama Feb. 17-19, 2016. Testart will present and discuss ...
(Date:11/30/2015)... ... 30, 2015 , ... Global Stem Cells Group ... the Santiago Marriott. The Global Stem Cells Group GMP facility is equipped with ... qualified medical researchers and practitioners, experienced in administering stem cell protocols using highly ...
(Date:11/30/2015)... , Dec. 1, 2015  An interventional radiology technique shows ... the preliminary results of a study being presented today at ... North America (RSNA). --> ... for decades by interventional radiologists as a way to stop ... procedure as a means of treating obesity is new. ...
Breaking Biology Technology: