Navigation Links
Mechanisms for a beneficial effect of moderate alcohol consumption on osteoporosis in women
Date:8/2/2012

Women after menopause tend to develop weaker bones from what is known as osteoporosis, which may lead to fractures (especially hip fractures) from falling. The weakness of the bones results from an imbalance between the normal resorption (a type of dissolving of old bone) and the laying down of new bone, an ongoing process for both men and women referred to as "bone turnover." For poorly understood reasons, after menopause the resorption of old bone in women continues but new bone is laid down less well, leading to a decrease in bone density. A variety of substances (calcium, vitamin D and various medications) have been used in an attempt to prevent the development of osteoporosis; in epidemiologic studies, moderate drinking of alcohol has also been shown to lower this risk.

An intervention by Marrone JA et al published in Menopause, involved 40 healthy postmenopausal women of an average age of 56. The authors measured factors that relate to osteoporosis in post-menopausal women while subjects were consuming alcohol (19g a day), after they had stopped drinking, and after they had resumed their alcohol consumption. The authors state that excessive bone turnover, combined with an imbalance whereby bone resorption exceeds bone formation, is the principal cause of post-menopausal bone loss and conclude that alcohol decreases the turnover of bone in post-menopausal women, which leads to less resorption of bone, hence less osteoporosis. The study also showed that abstinence from alcohol resulted in increased markers of bone turnover (hence, higher risk of developing osteoporosis), whereas resumption of alcohol consumption reduced bone turnover markers.

The authors attribute a cellular mechanism for the observed lower risk of osteoporosis among women who consume moderate amounts of alcohol.

International Scientific Forum on Alcohol Research reviewers considered this to be an innovative and well-done study. The key questions raised were how alcohol may affect bone metabolism in a longer period of time than was tested in this study. Reviewers realized that such long-term intervention trials are very difficult and expensive to carry out. On the other hand, many prospective epidemiologic studies in the elderly have shown greater bone mineral density and a lower risk of fractures among regular moderate drinkers than among abstainers. The most important aspect of this study may be that it has helped identify cellular mechanisms for the increased bone density observed in post-menopausal women who are moderate alcohol consumers.


'/>"/>
Contact: R. Curtis Ellison
ellison@bu.edu
Boston University Medical Center
Source:Eurekalert

Related biology news :

1. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
2. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
3. Discovery of mechanisms predicting response to new treatments in colon cancer
4. Symposium: Protein-Folding Diseases: Models & Mechanisms
5. Force of nature: Defining the mechanical mechanisms in living cells
6. Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body
7. Plant perfumes woo beneficial bugs
8. Beneficial bacteria may help ward off infection
9. Effects of environmental toxicants reach down through generations
10. More effective method of imaging proteins
11. The effect of catch-up growth by various diets and resveratrol intervention on bone status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... , Feb. 25, 2017  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... Recidivism and Reentry. "Too often, too ... prisons and county jails are trying to tackle ... inmates and friends and family members. While significant steps ...
(Date:2/21/2017)... , February 21, 2017 ... 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr als ... einige Hindernisse zu überwinden gilt, um diese Prognose zu ... ... anderem die Mobilisierung der finanziellen Mittel für die Biobank, ...
(Date:2/13/2017)... -- Former 9/11 Commission border counsel and Special Counsel ... of Identity Strategy Partners, LLP, today releases the ... Order: Protecting the Nation From Foreign Terrorist Entry Into ... President Trump,s ,Travel Ban, Executive Order gains more notoriety ... travel ban, it is important that our national discourse ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... 2017 /PRNewswire/ - The University of Missouri Research Reactor ... of Sterigenics International, and General Atomics (GA), announce that ... the U.S. Nuclear Regulatory Commission (NRC). This marks a ... (Mo-99). Once operational, production from this facility will be ... Mo-99, which currently must be imported from outside ...
(Date:3/29/2017)... The Global Microfluidic Chips Market by Manufacturers, Countries, Type ... study on the existing state of the global Microfluidic Chips industry ... and Asia-Pacific , South ... Africa . ... Browse 172 Tables and Figures, 13 Major Company Profiles, spread ...
(Date:3/28/2017)... ... March 28, 2017 , ... Mass spectrometry is becoming ... of this technology is driven by its potential to perform challenging analyses in complex ... some challenges that must be addressed for it to be routinely used for medical ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... II Small Business Innovation Research (SBIR) grant from the National Science Foundation (NSF). ... two years to develop a suite of BioGel™ biopolymer materials for hygiene applications, ...
Breaking Biology Technology: