Navigation Links
Mechanism found connecting metastatic breast cancer and arthritis
Date:4/1/2012

New research shows it may be no accident when doctors observe how patients suffering from both breast cancer and arthritis seem to have more aggressive cancer. However, the new-found interaction between the two diseases may also suggest a possible treatment.

A potential relationship between metastatic breast cancer and autoimmune arthritis, as suggested by past epidemiological studies, has led researchers from the University of North Carolina at Charlotte to perform a series of mouse model experiments that appear to confirm the connection.

"Epidemiological studies have implied that breast cancer survival is significantly lower in patients who also had autoimmune arthritis," noted Pinku Mukherjee, Irwin Belk Distinguished Scholar of Cancer Research at UNC Charlotte, whose lab conducted the experiments. "As there is no obvious reason this should be so, we were interested in exploring possible cancer mechanisms that might explain why."

The experiments point to an intimate relationship between mast cells immune system cells that are located in various tissues and that can cause inflammation and metastatic tumors.

In previously published studies, UNC Charlotte cancer researcher Lopamudra Das Roy and her mentor Mukherjee established that breast cancer associated metastases were significantly higher in arthritic mice, with a threefold increase in lung metastases and a twofold increase in bone metastases.

In their most recent work, the researchers found that mast cells and their associated inflammation are present in larger numbers in the bones and lungs of arthritic mice than they are in non-arthritic mice. Their findings point to a relationship between the cKit receptor found on mast cells and the transmembrane stem cell factor (SCF) ligand found on metastatic breast cancer cells. The interaction between SCF and cKit appears to play a critical role in facilitating metastasis.

"We confirmed the relationship w
'/>"/>

Contact: James Hathaway
jbhathaw@uncc.ed
704-687-5743
University of North Carolina at Charlotte
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers unravel genetic mechanism of fatty liver disease in obese children
2. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
3. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
4. Mechanism for Burgess Shale-type preservation
5. Another mechanism discovered by which sulforaphane prevents cancer
6. MDC researchers reveal molecular mechanism underlying severe anomalies of the forebrain
7. Immunological mechanisms of oncolytic adenoviral therapy
8. How protein networks stabilize muscle fibers: Same mechanism as for DNA
9. Sweeping genetic analysis of rare disease yields common mechanism of hypertension
10. Scientists uncover novel mechanism of glioblastoma development
11. Research team discovers genes and disease mechanisms behind a common form of muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... ground by alternately squeezing and stretching muscles along the ... of contractions. Snails and sea cucumbers also use this ... gastrointestinal tracts operate by a similar action, squeezing muscles ... Now researchers at MIT, Harvard University and Seoul ...
... of the Pediatric Infectious Diseases Society ( JPIDS ... to date of the impact on reducing the days ... prospective-audit-with-feedback antibiotic stewardship program (ASP). The study utilized ... the Child Health Corporation of America. A companion ...
... , Fresno, Calif. Consuming grapes may help protect ... new research published in the Journal of Nutrition ... risk factors for heart disease in men with metabolic ... inflammation. Natural components found in grapes, known as ...
Cached Biology News:Soft autonomous robot inches along like an earthworm 2Soft autonomous robot inches along like an earthworm 3First antibiotic stewardship probed in the Journal of the Pediatric Infectious Diseases Society 2Eating grapes may help protect heart health in men with metabolic syndrome, new study suggests 2
(Date:12/17/2014)... 2014 Xeno Diagnostics has again ... most recent COLA inspection. Xeno has met all ... healthcare accreditation organization. Accreditation is earned only by ... day-to-day operations, demonstrate continued accuracy in the performance ... laboratory survey. , While the Laboratory ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 Audacity, ... activation agency and member of the Huntsworth Health Group, ... to its executive team. In her role, Gonzales will ... , “We are incredibly honored to welcome a talent ... Chief and CEO, Gaëtan Fraikin. “She is a proven ...
(Date:12/17/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... as changes to Martine Rothblatt , Ph.D,s compensation ... United Therapeutics announced the promotion of Roger ... and David Zaccardelli , Pharm.D. to Executive Vice ... promotions, Dr. Rothblatt,s title will change from Chairman and ...
(Date:12/17/2014)... SAN FRANCISCO, Calif. , Dec. 17, 2014 ... results of a Phase 2 study evaluating the ... the treatment of patients with severe, chronic itch ... current standard of care, including topical steroids and ... was percent change in Visual Analog Scale (VAS) ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4
... Every year as the DEMO conference comes together , there's ... great in their own right, but for one reason or ... our invitation to launch at DEMO. , ,One such company ... summer. Founded by ex-Microsofter Soraya Bittencort, Mountain View, Calif.-based Nutrihand ...
... - University of Wisconsin assistant professor Helen Blackwell is being ... her work with bacteria and infections. , , Technology Review ... of Technology , recognized Blackwell as one of its top ... assistant professor of chemistry at UW-Madison, was honored for her ...
... each will receive $15,000 in funding for technology ... Gov. Jim Doyle announced Wednesday. , , Pointone ... Assistance Grant to hire professional grant research and ... company, in Wauwatosa, was established in 2001 to ...
Cached Biology Technology:The one that got away 2The one that got away 3UW researcher named top innovator 2
...
...
... The FDSS6000 System is an imaging ... assay development and high throughput screening ... luminescence modalities., The Hamamatsu light sources ... our companys decades-long experience in photon ...
... for enhanced translation of cloned sequences in vitro ... The maps for pCITE-2b(+) and pCITE-2c(+) are the ... is a 3793 bp plasmid; it lacks Nde ... sites. Subtract 7 bp from all sites beyond ...
Biology Products: