Navigation Links
Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
Date:12/7/2007

During muscle regeneration, which is a natural response to injury and disease, environmental cues cause adult muscle stem cells (satellite cells) to shift from dormancy to actively building new muscle tissue. Although the signaling pathways controlling muscle regeneration are fairly well known, how these signals lead to altered chromatin structure remains undiscovered. A group of scientists at the Burnham Institute for Medical Research in La Jolla, CA, analyzed the mechanism by which certain cellular signaling cues cause epigenetic modifications when released within the regenerative microenvironment, thus controlling the expression of genes that regulate growth and differentiation of muscle stem cells that repair injured muscle.

In a recent publication in Molecular Cell, the scientific group, led by Pier Lorenzo Puri, MD, Ph.D., shows how two signaling pathways, PI3K/AKT and p38, work together to assemble components of the protein complexes responsible for muscle-specific transcription, and how each pathway is responsible for a distinct step in the transcription process. Additionally, the team was able to pharmacologically separate these two steps, showing that selective interference with either cascade leads to incomplete assembly of protein complexes, thus preventing muscle-specific gene expression. The results point to possible pharmacological avenues for selective control of gene expression in adult muscle stem cells that may have therapeutic potential in regenerative medicine.


'/>"/>

Contact: Andrea Moser
amoser@burnham.org
858-646-3146
Burnham Institute
Source:Eurekalert

Page: 1

Related biology news :

1. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
2. Scientists find clue to mechanisms of gene signaling and regulation
3. Neural stem cell study reveals mechanism that may play role in cancer
4. New insight into the mechanisms of voltage sensing and transduction in biological processes
5. Mechanism for the in-vivo transport of siRNA
6. Scientists decipher mechanism behind antimicrobial hole punchers
7. Enhanced DNA-repair mechanism can cause breast cancer
8. Scientists enhance Mother Natures carbon handling mechanism
9. A mechanism to explain biological cross-talk between 24-hour body cycle and metabolism
10. Gene regulation, not just genes, is what sets humans apart
11. Evolution is driven by gene regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
(Date:11/7/2014)... , Nov. 7, 2014  In conjunction with the ... Police Departments, The Community Foundation of the Verdugos has ... DNA JUSTICE PROJECT," a $250,000 initiative to keep the ... phase. In its first six months of existence, the Lab ... evidence support for local law enforcement. "Because our ...
(Date:11/6/2014)... cancer deaths occur because of metastasis, yet progress ... been slow. , "It,s been particularly challenging to ... Gujral, research fellow in systems biology at Harvard ... detected until after they,ve already metastasized." , Gujral ... that should help researchers better understand how metastasis ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3
... Transposons are the Clark Kents of a genome. ... activity, these free-floating bits of genetic material have for ... of plants and animals, dramatically increasing a genome,s size. ... DNA was passive "junk" and knew little about it. ...
... 10, 2008) A study published in the current ... suggests that mature adipocytes - fat cells - could ... central nervous system disorders. , According to the study,s ... Medical Science, St. Mariana University School of Medicine, Kawasaki, ...
... Antioxidant-rich honey is a healthy alternative to chemical additives ... new University of Illinois study. "To capitalize on ... using honey in salad dressings," said Nicki Engeseth, a ... found that the antioxidants in honey protected the quality ...
Cached Biology News:New research shows how gene function drives natural selection in important class of genetic elements 2New research shows how gene function drives natural selection in important class of genetic elements 3Transplanted fat cells restore function after spinal cord injury 2Honey adds health benefits, is natural preservative and sweetener in salad dressings 2
(Date:11/26/2014)... Nov. 26, 2014 The announced sales of ... company is looking to expand in non-healthcare areas, says ... healthcare market research firm says that  Siemens is the ... biennial survey of the IVD market , with 5.5 ... in its composition would likely affect IVD market shares.  ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... from a survey of European physicians at the ... Innovation and Biological Therapies" at the Spanish Ministry ... hosted by EuropaBio and the Spanish Bioindustry Association ... Health, physicians from Spanish oncology and rheumatology societies, ...
(Date:11/26/2014)... 26, 2014 The ETC (Emerging ... technology innovation centers, announced today that applications for ... December 1st. “Do you have a big idea?,” ... want to know about it. AccelerateBaltimore helps you ... product in just 13 weeks.” Interested game ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to ... County (New Jersey) Chamber of Commerce as a ... organization in the North Jersey area, offers Whitehouse ... key clients in the pharmaceutical and biotechnology areas ... Membership enables Whitehouse Laboratories a higher level of ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2ASBM Presents European Physicians Survey at Spanish Ministry of Health 2AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3
... Introduction , ... 1 O 2 , is of considerable interest in environmental applications, ... been directed towards understanding the biological effects of 1 O 2 ... a dye, oxygen, and light. <P,>An understanding of the mechanisms that produce ...
... , ... The brightly-colored coral reefs that make scuba-diving and snorkeling ... essential to the survival of many species of fish and underwater life. ... hide from the larger predators, but also some fish actually survive by ...
... Introduction , ... human hair can be quantified with fluorescence spectroscopy. This is of significant interest ... , , ... involved in hair-care products, we performed the following evaluation using fluorescence spectroscopy. Two ...
Cached Biology Technology:Singlet Oxygen measurement 2Fluorescent pigments in living coral 2Fluorescent pigments in living coral 3Assessing UV damage of hair 2
Rabbit polyclonal to IL23 P19 ( Abpromise for all tested applications). Antigen: Synthetic 16 amino acid peptide from near the amino terminus of human IL23 P19 Entrez Gene ID: 51561 Swiss...
Complement C1q subcomponent subunit C precursor. [Source:Uniprot/SWISSPROT;Acc:P02747] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Monoclonal Mouse Anti-Human Cytokeratin 16 (48 kD)...
Mouse monoclonal [CRC64] to Integrin alpha 2b + beta 3 ( Abpromise for all tested applications). Antigen: Human platelets Entrez Gene ID: 23295 Swiss Protein ID: P05106...
Biology Products: