Navigation Links
Mechanism for link between high fat diet and risk of prostate cancer and disorders unveiled
Date:7/14/2010

CLEVELAND July 14, 2010 Prostate cancer is the second leading cause of cancer-related deaths in men with an estimated 192,280 new cases diagnosed in the US in 2009 (Jemal 2009). Diet is considered one of the most important controllable risk factors for inflammation and prostate diseases including benign prostatic hyperplsia (BPH), prostatitis, and prostate cancer.

Sanjay Gupta, MS, PhD, Carter Kissell associate professor & research director in the Department of Urology and associate professor in the Department of Nutrition in the Case Western Reserve School of Medicine, and his team of post-doctoral fellows have focused on understanding the mechanisms of the deleterious effects of a high fat diet on the prostate. Previously, Dr. Gupta's team demonstrated that nuclear factor kappa B (NF-B), a protein complex that controls DNA transcription which is activated as a result of inflammation and stress, is constitutively activate in human prostate adenocarcinoma and is related to tumor progression (Shukla S et al, Neoplasia, 2004).

In a study, "High Fat Diet Increases NF-B Signaling in the Prostate of Reporter Mice", released online today in the journal "The Prostate" (http://www3.interscience.wiley.com/journal/106561909/issue), Dr. Gupta and his team demonstrate that a high fat diet results in activation of NF-B in the abdominal cavity, thymus, spleen, and prostate (Vykhovanets et al, The Prostate, 2010). Non obese NF-B reporter mice were fed a high fat diet for four, eight, and 12 weeks. Compared with mice fed a regular diet, the high fat diet group had significant increases in prostate weight, and in the prostate expression of markers of oxidative stress (such as NADPH), and inflammation (such as the downstream targets of NF-B: nitric oxide synthase, and cyclooxygenase [COX-2]) were increased. These studies provide direct evidence that a high fat diet causes proliferation, inflammation, and oxidative stress that can lead to benign prostatic hyperplasia, prostatitis, and cancer of the prostate, some of the most common disorders affecting adult men.

"Our studies provide evidence that a high-fat diet increases the activation of NF-B along with elevated levels of NADPH oxidase components which might lead to intraprostatic inflammation. This study strengthens the link between a high-fat diettypical of "Western style" high fat dietas a potential cause of prostatic diseases including BPG and prostate cancer," said Dr. Gupta.


'/>"/>

Contact: Christina DeAngelis
christina.deangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Plant breathing mechanism discovered
2. Experiment turns up the heat on natural selection, reveals new details of an evolutionary mechanism
3. Researchers discover mechanism that limits scar formation
4. Researchers discover new mechanism for clearing blockages from smallest blood vessels
5. Surprising infection inducing mechanism found in bacteria
6. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
7. Key mechanism identified in metastatic breast cancer
8. Scientists crack code of critical bacterial defense mechanism
9. Study reveals a mechanism for mate selection
10. Study shows compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse
11. USC researchers identify key mechanism that guides cells to form heart tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... 25, 2016 , ... Lajollacooks4u has become a rising hotspot for specialized team ... its top attractions. Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, ... team-building experience. , Each event kicks off with an olive oil and salt-tasting competition. ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Scientists at ... line options being tried for mesothelioma may be hampering the research that could lead ... research. Click here to read it now. , The team evaluated 98 ...
(Date:5/24/2016)... 2016   MedyMatch Technology Ltd ., the data analytics ... decision support tools in the emergency room, announced today that ... Advanced Technology Industries (IATI) BioMed Conference. The ... 15th National Life Sciences and Technology Week, and is being ... in Tel Aviv, Israel . Gene ...
(Date:5/23/2016)... Ind. , May 23, 2016 Zimmer Biomet ... musculoskeletal healthcare, today announced that its Board of Directors has ... for the second quarter of 2016. The ... or about July 29, 2016 to stockholders of record as ... declarations of dividends are subject to approval of the Board ...
Breaking Biology Technology: