Navigation Links
Mechanism explains link between apolipoprotein E and Alzheimer's disease
Date:6/11/2008

Scientists have discovered a previously unknown mechanism by which apolipoprotein E, a molecule whose mutation is linked to Alzheimer's disease (AD), stimulates degradation of sticky amyloid beta (A?) protein within the brain. The research, published by Cell Press in the June 12 issue of the journal Neuron, may lead to a powerful new therapy for this devastating disease.

One of the primary characteristics of AD is the accumulation and deposition of neuron-damaging clumps of A? protein. Apolipoprotein E (ApoE), a cholesterol transport protein, is known to be a key regulator of brain A? levels, and it is likely that processes that regulate ApoE activity will influence A? deposition and clearance. "An isoform of ApoE, ApoE4, has been shown to confer dramatically increased risk for late-onset AD; however, the basis for this remains one of the major unanswered questions of disease pathogenesis," writes study author Dr. Gary E. Landreth from the Alzheimer Research Laboratory at Case Western Reserve University School of Medicine in Cleveland, Ohio.

Dr. Landreth and colleagues sought to unravel the link between ApoE, A? clearance in the brain, and an enhanced risk for AD. The researchers found that ApoE profoundly enhanced the intracellular and extracellular degradation of A?. This enhancement varied for different isoforms of ApoE with the ApoE4 isoform exhibiting an impaired ability to promote A? degradation when compared to other ApoE isoforms. The number of lipid molecules associated with ApoE was also critical to its ability to stimulate A? degradation. Activation of liver X receptors (LXRs) to enhance expression of lipidated ApoE significantly facilitated A? degradation. Importantly, use of an LXR agonist to increase lipidated forms of ApoE in a mouse model of AD resulted in reduced A? plaque levels and an improvement in contextual memory.

The results of this study document a major role for ApoE in the stimulation of A? degradation wit
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
2. Fruit fly avoidance mechanism could lead to new ways to control pain in humans
3. Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain
4. Scientists clarify a mechanism of epigenetic inheritance
5. CSHL scientists identify a mechanism that helps fruit flies lock-in memories
6. A common genetic mechanism discovered in nitrogen-fixing plants
7. Mechanisms of plant-fungi symbiosis characterized by DOE Joint Genome Institute
8. Scientists uncover a novel mechanism that regulates carbon dioxide fixation in plants
9. The Uukuniemi virus helps to explain the infection mechanism of bunyaviruses
10. USC researchers identify mechanism that controls activation of stem cells during hair regeneration
11. New treatment mechanisms for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Chinese University of Hong Kong, BGI and other ... to salt tolerance, with implication for improving this important ... online in Nature Communications provides an effective ... , Soybean is an important crop for the world. ... less genetic diversities than their wild counterparts. Among the ...
(Date:7/11/2014)... WASH. July 11, 2014 Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... to read a mouse,s mind, it takes some fluorescent protein ... Stanford scientists have demonstrated a technique for observing hundreds of ... real time, and have linked that activity to long-term information ... studying new therapies for neurodegenerative diseases such as Alzheimer,s. ...
... about to take up residence in the laboratories of Virginia ... to learn more about the water-running lizard,s ability to dart ... it increases its locomotion efficiency by producing more force on ... And these engineers are surprised at how some frog ...
... study led by an international team of biologists has identified some ... of their brain at a time. The study was published ... headed by scientists at UCLA and the University of Toronto. It ... half awake and asleep. Findings from this study may explain the ...
Cached Biology News:Stanford researchers develop tool for reading the minds of mice 2Nature's phenomena might teach Virginia Tech engineers new tricks 2Nature's phenomena might teach Virginia Tech engineers new tricks 3New study shows how seals sleep with only half their brain at a time 2
(Date:7/11/2014)... , July 11, 2014 /CNW/ - Sunovion Pharmaceuticals ... APTIOM TM (eslicarbazepine acetate) for use as a ... in patients with epilepsy who are not satisfactorily controlled ... for use in patients under 18 years of age. ... common neurological disorders and according to Epilepsy Canada, it ...
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
(Date:7/10/2014)... 10, 2014 Product and process ... low abundance and are often “lost in the ... , Join presenters Dr. Rowel Tobias, Senior Scientist, ... Anders, Head of Quality at Nanotherapeutics, Inc., to ... can speed detection and quantitation while achieving the ...
(Date:7/10/2014)... 10, 2014 Understanding the need for ... lines, and the gap that currently exists in this ... its industry-leading portfolio of validated ion channel and GPCR ... cell lines, as ion channels control many critical physiological ... activity creates the potential to treat a variety of ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... Emmanuel Labourier , Ambion, Inc , ... from the same sample Enrich for , ... , for assessing siRNA or miRNA expression and ... (siRNAs) and , microRNAs (miRNAs) have emerged as ...
... , High ... Only ethically sourced tissue is used , Custom RNA isolations from tissue ... Begins at the Source , Use ... that you are getting the highest , quality ...
... In Vitro Translation Kit , ... of protein than reticulocyte , lysate systems , ... biological activity than other E. coli , lysate systems ... researchers studying protein function and , ...
Cached Biology Technology:Isolate It All: siRNA miRNA , Total RNA Native Protein 2Isolate It All: siRNA miRNA , Total RNA Native Protein 3Isolate It All: siRNA miRNA , Total RNA Native Protein 4Isolate It All: siRNA miRNA , Total RNA Native Protein 5Isolate It All: siRNA miRNA , Total RNA Native Protein 6Isolate It All: siRNA miRNA , Total RNA Native Protein 7Isolate It All: siRNA miRNA , Total RNA Native Protein 8Isolate It All: siRNA miRNA , Total RNA Native Protein 9High Quality RNA Isolation Services 2Increase Protein Activity and Yield 2Increase Protein Activity and Yield 3
... 20 System revolutionizes DNA sequencing, delivering sequence ... The Genome Sequencer 20 System includes: ... consumables for library construction, amplification, and sequencing ... novo assembly The instrument ...
... Proteolytic degradation is critical to the ... and regulatory proteins as important and ... metabolism, heat shock and stress response, ... receptors and ion channels, cell cycle ...
Compound(s) tested through a broad panel of 38 ligand binding and enzyme assays targeting the Central Nervous System. Used to determine selectivity and potential CV/Renal liabilities of compounds....
... demonstrated that oxidative stress is involved in ... stress is the condition in which an ... exist leading to the damage of a ... stress is through several antioxidant systems4 that ...
Biology Products: