Navigation Links
Mechanism discovered which aids Legionella to camouflage itself in the organism
Date:5/22/2013

The feared Legionella pneumophila bacteria is responsible for legionellosis, an infectious disease that can lead to pneumonia. In order to infect us, this pathogen has developed a complex method enabling it to camouflage itself and go unnoticed in our cells, thus avoiding these acting against the infectious bacteria.

Research led by the Basque biosciences research centre, CIC bioGUNE, in which teams from the National Institute of Health (NIH) of the USA and the National Supercomputation Centre in Barcelona (BSC) have also participated, has described for the first time a mechanism that aids this bacteria to camouflage itself in human cells. The research, recently published in the prestigious PLOS Pathogens, resolved the structure of the SidD protein of the Legionella pneumophila, involved in the interference of cell processes during infection.

Legionella, which lives in stagnant water, gains access to our organism through the respiratory tract, when we inhale contaminated microscopic drops of water. Once there, the cells of the immune system phagocytise it (that is, they 'swallow' it up), but are not able to destroy it. This is due to the fact that the bacteria manages to manipulate the host cell to go unnoticed inside it and multiply itself without being destroyed.

The strategy of the bacteria involves releasing about 300 proteins into the cell, which in turn act on the host proteins in order to avoid being recognized as an infectious agent and thus go unnoticed during the time necessary to multiply itself.

One of these proteins, concretely the Legionella SidD protein, regulates a chemical modification involved in the process of intracellular camouflage. It is precisely the function of this protein which the research by CIC bioGUNE, the NIH and the BSC has described. Once the Legionell has managed to multiply itself, the SidD protein unblocks cellular processes which favour the advance of th
'/>"/>

Contact: Irati Kortabitarte
i.kortabitarte@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1 2

Related biology news :

1. SUMO wrestling cells reveal new protective mechanism target for stroke
2. Laminopathies: Key components in the disease mechanism identified
3. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
4. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
5. Important fertility mechanism discovered
6. Epigenetic changes shed light on biological mechanism of autism
7. Mechanism of mutant histone protein in childhood brain cancer revealed
8. Researchers find novel mechanism regulating replication of insulin-producing beta cells
9. New study identifies unique mechanisms of antibiotic resistance
10. UMass Amherst researchers reveal mechanism of novel biological electron transfer
11. Series of studies first to examine acupunctures mechanisms of action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014 Research and Markets ( ... "Global Chemical Sensor Market 2015-2019" report ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend upcoming ... medical sensors in biomedical applications. Chemical sensors help ... correct diagnosis during surgical procedures. The Global Chemical ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology ... system measures the overall facial feature of a ... the distance between eyes. Facial recognition is used ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... for convenient, nutritious foods increases, pre-cut and packaged fruit ... to science to discover new ways to safely extend ... potential solution to vegetables, short market life may be ... technology currently in use in commercial food operations. ...
... sudden fluctuations in the weather could be developed, thanks to ... Scientists studying how tiny algae renew old or damaged cell ... suited to climates in which weather changes quickly. Researchers ... dictates how quickly they can adapt to environmental changes, such ...
... (December 13, 2011) The Wildlife Conservation Society tracked a ... equivalent of New York to Sydney and back again. , ... 2011. The animal nicknamed Jackson was tagged ... in southern Chile. WCS conservationists fitted Jackson with a small ...
Cached Biology News:Asparagus benefits from X-ray treatment 2Elephant seal travels 18,000 miles 2
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application ... product specification, manufacturing process, and product cost ... and applications. The analysis also covers upstream ... channels, industry development trend and proposals. In ...
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
(Date:12/24/2014)... December 23, 2014 PharmaBoardroom,s ... out today and available for free download , digs ... change and growth in the sector today. One ... successes has been in developing a homegrown pharmaceutical manufacturing base, ... production still remains some way off. A cursory comparison with ...
(Date:12/24/2014)... and NEW YORK , Dec. ... its open-label pilot study of mazindol in children with ... and Therapy in December 2014 . ... in children with attention deficit/hyperactivity disorder" ( Konofal et ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows that ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... of visible light and zinc oxide nanorods for destroying ... at the Asian Institute of Technology (AIT). Nanorods grown ... been found to be effective in killing both gram ... has immense possibilities for affordable and environmentally friendly water ...
... May 12, 2011 Stem Cell Assurance, Inc. (SCLZ.PK) ... for Registration of Securities on Form 10 pursuant to Section ... 10 includes audited financial statements as of December 31, 2009 ... this filing, effective July 11, 2011, the Company will become ...
... May 12, 2011 The Maryland Academy of Sciences ... recipients of its Annual Awards which recognize the accomplishments ... Dr. Ian Appelbaum, Associate Professor of Physics at the ... (OYS) award and Dr. Ganesh Sriram, Assistant Professor in ...
Cached Biology Technology:Exposing ZnO nanorods to visible light removes microbes 22011 Outstanding Young Scientist and Engineer Named; Baltimore City High School Students Awarded Glass Scholarships 2
Agarase cleaves agarose to neoagaro-oligosaccharides, and is used for,quantitative, gentle recovery of DNA from low melting point agarose....
Request Info...
Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, Serine Protease Regulators...
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble...
Biology Products: