Navigation Links
Mechanism discovered which aids Legionella to camouflage itself in the organism
Date:5/22/2013

The feared Legionella pneumophila bacteria is responsible for legionellosis, an infectious disease that can lead to pneumonia. In order to infect us, this pathogen has developed a complex method enabling it to camouflage itself and go unnoticed in our cells, thus avoiding these acting against the infectious bacteria.

Research led by the Basque biosciences research centre, CIC bioGUNE, in which teams from the National Institute of Health (NIH) of the USA and the National Supercomputation Centre in Barcelona (BSC) have also participated, has described for the first time a mechanism that aids this bacteria to camouflage itself in human cells. The research, recently published in the prestigious PLOS Pathogens, resolved the structure of the SidD protein of the Legionella pneumophila, involved in the interference of cell processes during infection.

Legionella, which lives in stagnant water, gains access to our organism through the respiratory tract, when we inhale contaminated microscopic drops of water. Once there, the cells of the immune system phagocytise it (that is, they 'swallow' it up), but are not able to destroy it. This is due to the fact that the bacteria manages to manipulate the host cell to go unnoticed inside it and multiply itself without being destroyed.

The strategy of the bacteria involves releasing about 300 proteins into the cell, which in turn act on the host proteins in order to avoid being recognized as an infectious agent and thus go unnoticed during the time necessary to multiply itself.

One of these proteins, concretely the Legionella SidD protein, regulates a chemical modification involved in the process of intracellular camouflage. It is precisely the function of this protein which the research by CIC bioGUNE, the NIH and the BSC has described. Once the Legionell has managed to multiply itself, the SidD protein unblocks cellular processes which favour the advance of th
'/>"/>

Contact: Irati Kortabitarte
i.kortabitarte@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1 2

Related biology news :

1. SUMO wrestling cells reveal new protective mechanism target for stroke
2. Laminopathies: Key components in the disease mechanism identified
3. Study uncovers mechanism for how grapes reduce heart failure associated with hypertension
4. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
5. Important fertility mechanism discovered
6. Epigenetic changes shed light on biological mechanism of autism
7. Mechanism of mutant histone protein in childhood brain cancer revealed
8. Researchers find novel mechanism regulating replication of insulin-producing beta cells
9. New study identifies unique mechanisms of antibiotic resistance
10. UMass Amherst researchers reveal mechanism of novel biological electron transfer
11. Series of studies first to examine acupunctures mechanisms of action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... children with traumatic injuries have identified an immune ... develop a hospital-acquired infection. The study, led by ... in June in the journal Shock , ... lead to the clinical implementation of quick-turnaround immune ... immune system damage following critical illness or injury ...
(Date:7/9/2014)... Ill. With over 100 diseases that can attack ... top of the most wanted list? University of Illinois ... that more research is needed on the fungus that ... with cool, damp growing conditions but Macrophomina phaseolina ... and dry drought conditions. , "As the climate continues ...
(Date:7/9/2014)... Adlie penguins shows that the population is 3.79 ... previously estimated. Adlie penguins have long been considered ... the effects of climate change and fishing in ... imagery, researchers from Stony Brook University and University ... permits regular monitoring of Adlie penguins across their ...
Breaking Biology News(10 mins):Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... CLEVELAND, Nov. 21, 2011 Already partnering with 43 ... world,s Top 100 Innovators, NineSigma today announced a record ... innovation is critical to their long-term growth. ... that never hesitate in their quest to innovate," said ...
... to measure their abundance has never been simple. A new ... and eight other scientists shows that expanding ocean dead zones ... wrinkle to that science. In the December 4 paper ... these scientists sound an alarm that expanding ocean dead zones ...
... Virginie Stevens ( CNRS ), Jean Clobert (CNRS), Michel ... show that interactions between dispersal and life-histories are complex, ... open access paper in the journal Ecology ... role in gene flow among populations, its evolutionary dynamics ...
Cached Biology News:Surging Demand for Innovation Services Leads to Record Expansion for NineSigma 2Surging Demand for Innovation Services Leads to Record Expansion for NineSigma 3Expanding dead zones shrinking tropical blue marlin habitat 2Expanding dead zones shrinking tropical blue marlin habitat 3Butterflies: 'Twice-punished' by habitat fragmentation and climate change 2
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... Wis. - NameProtect , a Madison-based supplier ... Wednesday it has entered a partnership with Corillian ... state of Oregon. , ,The companies will jointly market ... streamlining and improving both companies' anti-fraud solutions. The pairing ...
... is taking the business world by storm, or so it ... outsourcing topics featured in business and IT publications and websites. ... two recently released studies on outsourcing published by leading consulting ... accentuate the negative aspects of this management practice. , ,Both ...
... Madison, Wis. - Alfalight, Inc. , a ... and telecommunications markets, has been awarded $1.4 million in ... Diode Sources program, sponsored by the Defense Advanced ... the project is to increase a laser's power conversion ...
Cached Biology Technology:Is outsourcing reaching its limits or simply pausing for breath? 2Is outsourcing reaching its limits or simply pausing for breath? 3Is outsourcing reaching its limits or simply pausing for breath? 4Alfalight garners $1.4 million defense funding for diode program 2