Navigation Links
Mechanism behind demethylation pinpointed in APC gene mutants
Date:9/17/2010

Salt Lake City, September 17, 2010Colon cancer is the second most common cancer in the United States and causes more than 50,000 deaths each year. It has been known for some time that mutations in the APC gene occur in more than 85 percent of all sporadic colon cancers. Now researchers at Huntsman Cancer Institute at the University of Utah demonstrate in a study featured today in Cell the mechanism by which mutation of the APC gene affects a cellular process known as DNA methylation. DNA methylation is a chemical modification made to DNA that plays an important role in dictating how DNA is read and interpreted by a cell.

The group, led by David Jones, Ph.D., and Bradley Cairns, Ph.D., have now linked loss of Apc with DNA demethylase, an enzyme system that erases DNA methylation. Studies using human tissues and zebarafish demonstrate that this system is highly active in tissues harboring mutated Apc and may provide an explanation for the previously known loss of DNA methylation seen in early stage tumors. The activity of the DNA demethylase appears to stall the normal development of intestinal cells, leaving them in a stem cell-like state. Normal development was restored upon inhibition of the DNA demethylase system. The experiments conducted by the group also demonstrated that the mechanistic connection between APC mutation and demethylation is conveyed through changes in the amount of retinoic acid (RA), an important regulatory compound derived from dietary vitamin A.

"We believe that clarification of the mechanism leading to demethylation will have broad implications for a variety of cancers. Our increased understanding of the mechanics connecting APC mutation and demethylation presents new opportunities for colon cancer intervention and may lead the way to developing a truly finely tuned approach to treatment," said Jones. Cairns added, "Since the mechanism of action of the demethylase can inherently create new mutations, misregulation
'/>"/>

Contact: Linda Aagard
linda.aagard@hci.utah.edu
801-587-7639
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Conaway Lab identifies novel mechanism for regulation of gene expression
2. Rong Li Lab probes mechanism of asymmetry in meiotic cell division
3. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
4. Scientists unveil mechanism for up and down in plants
5. New cell division mechanism discovered
6. Corn researchers discover novel gene shut-off mechanisms
7. New regulatory mechanism discovered for cell identify and behavior in forming organs
8. Biomedical engineers detective work reveals antibiotic mechanism
9. Mechanisms of cardiovascular disease and cancer give clues to new therapies
10. Argonne scientists discover possible mechanism for creating handedness in biological molecules
11. A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... crucial for providing essential fatty acids and energy ... There has been concern that soybean-based emulsions could ... to its composition. Combination lipid emulsions based on ... been developed to address this concern. , However, ... concern may be unwarranted, according to a review ...
(Date:7/22/2014)... research from the Monell Center reveals that simply believing ... inflammation in asthmatics for at least 24 hours following ... play in health-related outcomes. , "Asthmatics often are anxious ... odor is harmful, our bodies react as if that ... Jan, PhD, a Monell physiologist. "Both patients and care ...
(Date:7/22/2014)... survival rates of 12 different shark species when ... found large differences in survival,rates across the 12 ... being the most,vulnerable. The study, led by researchers ... of,Marine and Atmospheric Science and UM Abess Center ... consider for future conservation measures for sharks in ...
Breaking Biology News(10 mins):In asthma, it's not just what you smell, but what you think you smell 2In asthma, it's not just what you smell, but what you think you smell 3New study reveals vulnerability of sharks as collateral damage in commercial fishing 2
... NY -- Think of the smell of an orange, a lemon, ... sweetness. And yet each fresh, bright scent is distinguishable from ... chemical compounds. How, then does the brain tell them apart? ... chemical signature as a particular scent? Researchers at ...
... at the University of Saskatchewan have discovered new potential ... buckthorn, according to a new study published today in ... showed that these fruits were nutrient-rich and that the ... for fruit growers in Saskatchewan as these results add ...
... ability of invasive plants to rapidly adapt to local climates -- ... in how quickly they spread. According to new research published ... is rapid evolution -- as much as resistance to local pests ... northern Ontario. "The ability of invasive species to rapidly adapt ...
Cached Biology News:Neuron 'claws' in the brain enable flies to distinguish 1 scent from another 2New potential for nutrient-rich prairie fruits 2Adaptability to local climate helps invasive species thrive 2
(Date:7/22/2014)... Piscataway, NJ (PR Web) July 21, 2014 (PRWEB) ... Jersey Center for Biomaterials, at Rutgers University. ... exchange information and ideas across the full spectrum ... focusing on selected research and development topics that ... application. Activities have been programmed to:, ...
(Date:7/22/2014)... Dr. Terry Baughn, a senior lecturer in mechanical engineering ... named Engineer of the Year by the North Texas ... , ASME has more than 130,000 members in 158 ... share technology to assist the engineering community, benefiting the ... the Texas Society of Professional Engineers honors banquet. Baughn ...
(Date:7/22/2014)... 2014 Rice Lake Weighing ... 2014 NCSL International Workshop and Symposium July 28-31 ... CONDEC pressure instrumentation, OIML M1 weights, precision lab ... customized sets, Essential Weights™. , NCSL International was ... in solving the common problems faced by measurement ...
(Date:7/22/2014)... CAMBRIDGE, Massachusetts og SHENZHEN ... BGI Tech Solutions Co., LTD, (BGI Tech), et ... globale lancering af en ny human whole exome-sekvenseringstjeneste ... Complete Genomics, højt anset i branchen for ... og højfølsom registrering af alle typer varianter, blev ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2UT Dallas professor receives Engineer of the Year award 2Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2BGI Tech lancerer Human Whole Exome-sekvenseringstjeneste på Complete Genomics avancerede platform 2
... thermal analysis equipment market is poised to exceed $539 million by ... are few lucrative areas that are expected to drive the industry,s ... ... CA (PRWEB) November 10, 2008 -- Economic trends, mergers & acquisitions ...
... CriticalMix Drug Delivery Technology and own Pipeline ... ... England, November 10 Critical,Pharmaceuticals, the speciality pharmaceuticals company, today ... totalling,GBP650,000. Based on the company,s success in developing its unique,CriticalMix ...
... electric power generator able to produce alternating current through ... encapsulated in a flexible plastic substrate with two ends ... generator is the fourth generation of devices designed to ... zinc oxide structures to harvest mechanical energy from the ...
Cached Biology Technology:Calorimeters and Thermal Analysis Equipment Market to Exceed $539 Million by 2012, According to New Report by Global Industry Analysts 2Calorimeters and Thermal Analysis Equipment Market to Exceed $539 Million by 2012, According to New Report by Global Industry Analysts 3Critical Pharmaceuticals Raise GBP650K 2Critical Pharmaceuticals Raise GBP650K 3New small-scale generator produces alternating current by stretching zinc oxide wires 2New small-scale generator produces alternating current by stretching zinc oxide wires 3
... CoA ligase (AMP forming), Acetate thiokinase ... content. Physical form: Lyophilized powder ... reduced glutathione Preparation Unit Definition: ... S-acetyl coenzyme A from acetate, ATP and ...
... is a new product number, created ... If showing no availability yet, please ... (Z71,487-9) or contact customer service for ... 100 mm, No. of sidearm 4 ...
... is a nucleoside antibiotic ... is a potent translational ... and eukaryotic cells. Resistance ... by the products of ...
... Aph-1a (Aph-1aL,S Loop 92-115), O2F1 Affinity ... a multiprotein complex consisting of presenilin, ... proteins are necessary for full proteolytic ... cleavage of a number of integral ...
Biology Products: