Navigation Links
Mechanism affecting risk of prostate cancer is found
Date:1/13/2014

A research group at Biocenter Oulu in Finland has identified a mechanism related to a transcription factor that binds much more strongly onto a particular SNP variant, thereby initiating a genetic programme which enhances prostate cancer proliferation and metastasis. The study opens up an important new direction in investigating the mechanisms related to the way in which SNP variations cause an elevated risk of prostate cancer and other human diseases. Published in Nature Genetics, the study was partly funded by the Academy of Finland.

Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer-related deaths in men worldwide. In Finland, more than 4,000 new cases are diagnosed every year.

The human genome is mainly identical throughout the human population worldwide. However, millions of small variations or polymorphisms, often located in a single nucleotide, can be found between individuals. These variations are known as single nucleotide polymorphisms (SNP). Using DNA samples from tens of thousands of prostate cancer patients and healthy men, comparative genetic studies, known as genome-wide association studies, have identified dozens of SNPs associated with the risk of prostate cancer. However, because most of these SNPs are not found in the protein-coding regions of the genome, finding the genes that contribute to the risk of prostate cancer is difficult. For this reason, the question of how these single nucleotide genetic variations or SNPs lead to a risk of prostate cancer has not yet been answered.

The research for this international and multidisciplinary study was led by Junior Investigator Gonghong Wei, with a team of scientists from several universities and research institutes. These included three universities in Finland (Oulu, Tampere and Helsinki), Karolinska Institutet in Sweden and Fudan University in China.


'/>"/>

Contact: Dr. Gonghong Wei
gonghong.wei@oulu.fi
358-504-288-121
Academy of Finland
Source:Eurekalert

Page: 1

Related biology news :

1. Mechanism for Burgess Shale-type preservation
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
4. Researchers unravel genetic mechanism of fatty liver disease in obese children
5. Mechanism found connecting metastatic breast cancer and arthritis
6. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
7. New genetic mechanism of immune deficiency discovered
8. Housekeeping mechanism for brain stem cells discovered
9. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
10. Researchers find mechanism that gives plants balance
11. New key mechanism in cell division discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... Feb. 2, 2017  EyeLock LLC, a market leader ... white paper " What You Should Know About Biometrics ... ensuring user authenticity is a growing concern. In traditional ... users. However, traditional authentication schemes such as username/password suffer ... Biometric authentication offers an elegant solution to the problem ...
(Date:1/31/2017)... 2017  Spero Therapeutics, LLC, a biopharmaceutical company ... of bacterial infections, today announced it has acquired ... Pro Bono Bio Ltd (PBB) to bolster its ... forms of Gram-negative bacteria.   The assets acquired have ... PBB group company. "The acquisition of ...
(Date:1/26/2017)... , Jan. 26, 2017  Acuity Market ... for Biometrics and Digital Identity".  Acuity characterizes 2017 ... identity when increased adoption reflects a new understanding ... "Biometrics and digital identity are often ... Maxine Most , Principal of Acuity Market ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... 2017 China Biologic Products, Inc. (NASDAQ: CBPO) ("China ... company in China, today announced its financial results for the ... Fourth Quarter 2016 Financial Highlights Total ... in RMB terms, or increased by 13.6% in USD terms ... of 2015. Gross profit increased by 13.3% ...
(Date:2/23/2017)... ... February 23, 2017 , ... BellBrook ... portfolio to include an array of biochemical analyses critical for Lead Discovery. ... their hit-to-lead and SAR programs, including inhibitor potency and selectivity, mechanism of action, ...
(Date:2/23/2017)... ROCHESTER, Minn. , Feb. 23, 2017 /PRNewswire/ ... a new product line of oncolytic vaccinia viruses ... Genelux Corporation as part of Genelux,s proprietary, vaccinia ... "We are excited to enter into a partnership ... time, selected oncolytic vaccinia viruses for use in ...
(Date:2/23/2017)... ... 23, 2017 , ... The Greater Gift Initiative, Inc , (GGI) a ... Research . GGI's mission is to advance global health and highlight the greater good ... honor of each clinical trial volunteer. The vision of GGI is to serve as ...
Breaking Biology Technology: