Navigation Links
Mechanism affecting risk of prostate cancer is found
Date:1/13/2014

A research group at Biocenter Oulu in Finland has identified a mechanism related to a transcription factor that binds much more strongly onto a particular SNP variant, thereby initiating a genetic programme which enhances prostate cancer proliferation and metastasis. The study opens up an important new direction in investigating the mechanisms related to the way in which SNP variations cause an elevated risk of prostate cancer and other human diseases. Published in Nature Genetics, the study was partly funded by the Academy of Finland.

Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer-related deaths in men worldwide. In Finland, more than 4,000 new cases are diagnosed every year.

The human genome is mainly identical throughout the human population worldwide. However, millions of small variations or polymorphisms, often located in a single nucleotide, can be found between individuals. These variations are known as single nucleotide polymorphisms (SNP). Using DNA samples from tens of thousands of prostate cancer patients and healthy men, comparative genetic studies, known as genome-wide association studies, have identified dozens of SNPs associated with the risk of prostate cancer. However, because most of these SNPs are not found in the protein-coding regions of the genome, finding the genes that contribute to the risk of prostate cancer is difficult. For this reason, the question of how these single nucleotide genetic variations or SNPs lead to a risk of prostate cancer has not yet been answered.

The research for this international and multidisciplinary study was led by Junior Investigator Gonghong Wei, with a team of scientists from several universities and research institutes. These included three universities in Finland (Oulu, Tampere and Helsinki), Karolinska Institutet in Sweden and Fudan University in China.


'/>"/>

Contact: Dr. Gonghong Wei
gonghong.wei@oulu.fi
358-504-288-121
Academy of Finland
Source:Eurekalert

Page: 1

Related biology news :

1. Mechanism for Burgess Shale-type preservation
2. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
3. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
4. Researchers unravel genetic mechanism of fatty liver disease in obese children
5. Mechanism found connecting metastatic breast cancer and arthritis
6. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
7. New genetic mechanism of immune deficiency discovered
8. Housekeeping mechanism for brain stem cells discovered
9. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
10. Researchers find mechanism that gives plants balance
11. New key mechanism in cell division discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... 2015 In the current ... outperforms the strongest competitors, showing outstanding performance in ... system is capable of a throughput of 5.000.000 ... to be ten times faster than most competitors ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) ...
(Date:4/1/2015)... BOSTON , April 1, 2015   Medisafe ... 1.5 million users across iOS and ... has begun integrating biofeedback into the platform to allow ... health outcomes. For the first time, patients will be ... missing a dose impacts important biometrics, such as glucose ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has announced ... 2015-2019" report to their offering. The ... at a CAGR of 23.5 percent over the period ... and the growth prospects of the Global Iris Recognition ... size, the report considers the revenue generated from sales ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... determined that milk thistle extract, a widely used ... on the course of patients with alcoholic liver ... These findings are published in The American ... studies, milk thistle extracts have been shown to ...
... more than half of children with sore throat, exceeding ... antibiotics for 27 percent of children who received an ... 9 issue of JAMA. , Pharyngitis (inflammation of the ... to family medicine physicians and pediatricians, according to background ...
... young scientists in the University of York's Department of ... patients some of the unpleasant and dangerous side-effects of ... together with post-doctoral research fellow Mark Godber, have developed ... tumours more efficiently. , Now, the group has secured ...
Cached Biology News:Children overprescribed antibiotics for sore throat 2Young scientists turn to gel to ease side-effects of cancer treatment 2
(Date:4/28/2015)... Spartan Bioscience today announced that Paul ... by the Ottawa Chamber of Commerce as one of ... selected from over 240 applicants based on his business ... Spartan, Dr. Lem founded Plexagen Diagnostics, and also served ... a Medical Degree from the University of Ottawa, and ...
(Date:4/27/2015)... , April 27, 2015  For about a ... is their ability to utilize and catabolize glucose ... cancer cells is called the ,Warburg phenomenon", that ... of high oxygen presence, leading to enhanced lactate ... cells still choose glucose fermentation. A variety of ...
(Date:4/27/2015)... Diego, Calif. (PRWEB) April 27, 2015 ... of drug and chemical toxicity carries implications for advancing ... speaker April 28 at National University , the ... and presentation by Dr. Hanzlik, a professor at the ... drug metabolism and drug design, starts at 5 p.m. ...
(Date:4/27/2015)... BRUNSWICK, New Jersey , 27 ... société de découverte médicamenteuse spécialisée dans ... antibiotiques destinés à soigner les infections ... aujourd,hui la présentation de données prouvant ... majeur, le TXA709, dans la lutte ...
Breaking Biology Technology:Spartan Bioscience Announces Paul Lem Named Ottawa’s Top 40 Under 40 2Study Indicates Cancer Cells Alter Glucose Metabolism to Enhance Energy Production and Cell Growth 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 2TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 4TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 5TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 6
... in a line of reports paints a bleak picture ... such financing could be at its lowest level in ... to year's end. , ,The Money Tree Survey ... and the National Venture Capital Association, indicates that, unless ...
... Chippewa Valley representatives hope to score points with medical ... the largest medical device tradeshow in the Midwest. ... Minneapolis Convention Center on November 2nd and 3rd is ... company executives. , ,The twelve representatives include economic development ...
... Madison, Wis. - Sonic Foundry Inc. announced today ... "E-rate" program, which offers schools around the country the ... , ,The E-rate program is designed to provide discounts ... for the cost of education technology. Funded technology includes ...
Cached Biology Technology:While some bemoan lack of venture capital, entrepreneur touts `bootstrapping' for cash 2While some bemoan lack of venture capital, entrepreneur touts `bootstrapping' for cash 3While some bemoan lack of venture capital, entrepreneur touts `bootstrapping' for cash 4Chippewa Valley reps hope to score at Twin Cities tradeshow 2
TUNEL Apoptosis Detection Kit...
... assay kit measures NOS activity by monitoring ... This assay is simple, sensitive, and specific ... with both crude and purified enzyme preparations. ... for 50 total reactions. Radiolabeled arginine and ...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Mouse Axl MAb (Clone 175128)...
Biology Products: