Navigation Links
Mechanical stress can help or hinder wound healing depending on time of application
Date:10/24/2011

ion with Nathaniel Huebsch and David Mooney from Harvard University.

In one group of animals, plates screwed onto the bones to maintain limb stability prevented mechanical forces from being applied to the affected bone. In another group, plates allowed compressive loads along the bone axis to be transferred, but prevented twisting and bending of the limbs. The researchers used contrast-enhanced micro-computed tomography imaging and histology to quantify new bone and blood vessel formation.

The experiments showed that exerting mechanical forces on the injury site immediately after healing began significantly inhibited vascular growth into the bone defect region. The volume of blood vessels and their connectivity were reduced by 66 and 91 percent, respectively, compared to the group for which no force was applied. The lack of vascular growth into the defect produced a 75 percent reduction in bone formation and failure to heal the defect.

But the study found that the same mechanical force that hindered repair early in the healing process became helpful later on.

When the injury site experienced no mechanical force until four weeks after the injury, blood vessels grew into the defect and vascular remodeling began. With delayed loading, the researchers observed a reduction in quantity and connectivity of blood vessels, but the average vessel thickness increased. In addition, bone formation improved by 20 percent compared to when no force was applied, and strong tissue biomaterial integration was evident.

"We found that having a very stable environment initially is very important because mechanical stresses applied early on disrupted very small vessels that were forming," said Guldberg, who is also the director of the Petit Institute for Bioengineering and Bioscience at Georgia Tech. "If you wait until those vessels have grown in and they're a little more mature, applying a mechanical stimulus then induces remodeling so that
'/>"/>

Contact: Abby Robinson
abby@innovate.gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Lockheed Martins HULCâ„¢ Robotic Exoskeleton Enters Biomechanical Testing at U.S. Army Natick Soldier Systems Center
2. Virginia Tech mechanical engineers win measurement science best paper award
3. Muscle filaments make mechanical strain visible
4. Air flows in mechanical device reveal secrets of speech pathology
5. Bioengineers provide adult stem cells with simultaneous chemical, electrical and mechanical cues
6. UCLA physicists control chemical reactions mechanically
7. Scientists identify molecules involved in touch and other mechanically activated systems
8. Mechanical regulation of cell substrates effects stem cell development, adhesion
9. Cellular mechanical forces may initiate angiogenesis
10. Scientists create artificial human skin with biomechanical properties using tissue engineering
11. Small mechanical forces have big impact on embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mechanical stress can help or hinder wound healing depending on time of application
(Date:8/29/2014)... Dartmouth researchers explored the type and number of connections ... assortativity plays on robustness in a study published in ... study found that the assortativity signature contributes to a ... seems that varying the out-out assortativity of TFN models ... of the other three types of assortativity," said Dov ...
(Date:8/29/2014)... Kansas City, MO. - In a cell,s nucleus, ... known as histones, an amalgam biologists call chromatin. ... as a nuclear "sidekick," the mere packing material ... Recently, however, biologists have developed a greater appreciation ... In 2012, investigators from multiple research institutions studying ...
(Date:8/28/2014)... Entomological Society of America (ESA) is pleased to announce ... Member of the Society. Honorary Membership acknowledges those who ... significant involvement in the affairs of the Society that ... are selected by the ESA Governing Board and then ... be honored at the Awards Ceremony at Entomology 2014, ...
Breaking Biology News(10 mins):Assortativity signatures of transcription factor networks contribute to robustness 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Fred Baxendale selected as Honorary Member of the Entomological Society of America 2
... DC (February 19 2014) The lifelong debate of ... watch. A recent paper published in the Journal ... the serotonin-transporter gene was linked to children who engaged ... violent video games. Sanne Nikkelen, Helen Vossen, and ...
... stick insects don,t need to stick. In fact, when moving ... required to ,unstick, again with every step. , ... insects have specialised pads on their legs designed to produce ... stick insects aren,t sticking at all, but harnessing powerful friction ...
... Qi, from QUT,s Institute of Health and Biomedical Innovation, studied ... years and found variations in temperatures coupled with spikes in ... completed as part of his PhD, has helped to pinpoint ... suicide. "What we found was that when the difference ...
Cached Biology News:Genetics linked to children viewing high amounts of violent media 2How stick insects honed friction to grip without sticking 2How stick insects honed friction to grip without sticking 3Climate change linked to increase in Australia's suicide rates: QUT study 2
(Date:8/28/2014)... converters are important devices in spintronics, an electronic ... of electrons but also on their spin and ... of electric into magnetic signals and vice versa. ... from the Institute of Physics at Johannes Gutenberg ... UK, Prague, and Japan, has for the first ...
(Date:8/28/2014)... Aug. 28, 2014   SunTrust Robinson Humphrey ... veterans to its equity research team in biotechnology ... expansion in equity research demonstrates our commitment to ... to enhance their investment decision making," said ... "We continue to make significant investments in differentiated ...
(Date:8/28/2014)... August 27, 2014 Scientists, researchers, and ... SPIE Laser Damage 2014 symposium. Marking its ... high-power lasers will run 14-17 September. The event is ... and photonics . , The premier conference for basic ... damage to optical materials will engage researchers and engineers ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... is offering a promotion for Eppendorf Safe ... customers to purchase the highest quality tubes at ... are ideal for customers doing chemical, medical, pharmaceutical, ... technicians who are not regularly able to afford ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... CREEK, Calif., Sept. 11 A project to ... will be funded by a,new $1.6 million, three-year ... and others., The agreement, intended to bring ... is between The National Fragile X Foundation (NFXF),the ...
... - Validates Position as Leading Innovator in Pharmaceutical ... MonoSol Rx, a drug delivery,company specializing in ... it has been granted U.S. patent No. 7,425,292 ... The patent, which is expected to issue ...
... (Nasdaq: NTII ), today announced it will release,its ... September,16, 2008., The Company will also host a ... year-end call are as follows:, -- Date: ... ET, 9:30 a.m. CT, 7:30 a.m. PT -- ...
Cached Biology Technology:$1.6 Million Agreement to Accelerate Fragile X Research, Inspire Hope 2MonoSol Rx Granted Strategic US Patent for Thin Film Manufacturing Process 2MonoSol Rx Granted Strategic US Patent for Thin Film Manufacturing Process 3Neurobiological Technologies Announces Dates for 2008 Fiscal Year End Financial Results Conference Call and Presentation at MCF Investor Summit 2
... The Bio-Stack is compatible with BioTeks ... Speed, ease of use and walkaway ... microplate process. When used with the ... dispenser, the Bio-Stacks small footprint fits ...
... in the evolution of laboratory automation. A ... labware to multiple laboratory instruments, LabLinx gives ... of ordinary microplate robots. It allows the ... to meet any labs specific automation needs, ...
... ELx50 is a fast and versatile automated ... our patented Dual-ActionTM 16-channel manifold. This breakthrough ... dispense and aspiration manifolds for overfill washing ... 384-well formats. The problem of fitting dispense ...
... the use of small interfering RNA (siRNA) ... RNA interference (RNAi) pathway have generated tremendous ... fields. siRNA for experimental use can be ... and then transfected into the target cells ...
Biology Products: