Navigation Links
Mechanical forces driving breast cancer lead to key molecular discovery
Date:3/27/2014

ls. The miR-18a dials down the levels of a protective, tumor-suppressing protein called PTEN, which often is disabled in cancerous cells, leading to abnormal biochemical signaling that can promote cancer growth.

Stiffening of the tissue microenvironment in tumors

Weaver is a trained biochemist, and has been a trailblazer in the study of tissue mechanics and cancer for 15 years. Mouw is a mechanical engineer. The newly reported UCSF discovery highlights the importance of mechanical forces in the development of cancer, which usually is thought of in biochemical terms.

Armed with modern lab techniques, Weaver has made many discoveries about the mechanical and structural properties of tumor tissue and the stiffening that can occur. For example, she was the first to identify the cross-linking of structural elements within the ECM as a precursor to cancer progression.

Her research team's latest findings are of clinical interest because they may lead to earlier identification of certain difficult-to-treat breast cancers. About 60 percent of breast cancers can be easily identified as a type known as luminal breast cancer, but there are two subtypes of luminal breast cancer that are difficult to distinguish.

Luminal A breast cancer accounts for about 40 percent of all breast cancers, while luminal B breast cancer comprises about 20 percent. On average, women with luminal B breast cancer do not survive as long after treatment without breast cancer recurring, and they are less likely to respond to hormone therapies such as tamoxifen. Lack of a good diagnostic tool results in overtreatment of many luminal A breast cancers, Weaver said.

According to Shelley Hwang, MD, PhD, chief of breast surgery at Duke University Hospital, former UCSF faculty member and a clinical collaborator for the Nature Medicine study, "Current methods for distinguishing luminal A breast cancer from luminal B breast cancer are expensive and t
'/>"/>

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer cant hide; better heart shocks; mechanical leeches
2. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
3. Biomechanical performances of old-fashioned leather and modern football helmets
4. Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
5. Deep inside the body, tiny mechanical microscope
6. Force of nature: Defining the mechanical mechanisms in living cells
7. Mechanical properties and microstructure of cranial and beak bones of the woodpecker and the lark
8. Europe is joining forces against neglected parasitic diseases
9. Crop-infecting virus forces aphids to spread disease
10. Patients and scientists join forces to tackle Friedreichs Ataxia
11. ORNL study uses neutron scattering, supercomputing to demystify forces at play in biofuel production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... JOSE, Calif. , Nov. 20, 2014   ... global leader in microcontroller (MCU) and touch technology solutions, ... digital temperature sensors with the widest V cc ... delivers higher temperature accuracy and faster I 2 C ... registers and serial EEPROM memory making them ideal for ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
... professor Deborah Steinberg of the Virginia Institute of Marine Science ... aboard the research vessel Laurence M. Gould. The VIMS ... in the waters along the west coast of the Antarctic ... microscopic animals that form the base of the Antarctic food ...
... binding oxygen to metalloporphyrins is a vital process for ... bound to the metal complex is also important in ... these binding mechanisms, scientists use porphyrin rings with a ... or silver support surface with these substances. An ...
... The world,s oceans are under siege. Conservation biologists regularly ... bluefin tuna, swordfish and sharks. Lose enough of these top-line ... oceanic web of life may collapse. In a new ... the University of Washington used a group of marine creatures ...
Cached Biology News:VIMS team returns to Antarctic Peninsula 2VIMS team returns to Antarctic Peninsula 3Direct observation of carbon monoxide binding to metal-porphyrines 2Species loss tied to ecosystem collapse and recovery 2Species loss tied to ecosystem collapse and recovery 3
(Date:11/21/2014)... DIEGO , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Marc Hedrick , M.D. will present live at VirtualInvestorConferences.com on ... 2014 TIME:    11:15 am PT / 2:15 pm ... URL into your browser,s address bar: http://bit.ly/1B2KGaL ... and receive event updates. This will be ...
(Date:11/18/2014)... , Nov. 18, 2014 Cord Blood ... sponsor of the 10th Annual World Stem Cell Summit, the ... stakeholders. The 2014 World Stem Cell Summit will be held ... Antonio, Texas . The World ... development of lifesaving cures and therapies, convening the most prominent ...
(Date:11/18/2014)... (PRWEB) November 17, 2014 ... open architecture blade-based and rackmount computing infrastructure, today ... K80 dual-GPU accelerator throughout its GPU-enabled blade server ... of the company’s latest proprietary 80-lane Gen3 PCIe ... discrete NVIDIA Tesla K80 dual-GPU accelerator cards in ...
(Date:11/18/2014)... CA (PRWEB) November 17, 2014 Athena Signature ... Salk , Dr. Beverly Emerson, a professor in the Regulatory ... genes. Her most recent discovery points to an “off switch” ... Emerson’s career and how her local research is making a ... present her findings and then join host Cheryl K. Goodman, ...
Breaking Biology Technology:Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3
... 2011 The current revision of two ... blood-related diseases must ensure the safety of patients and ... was a key message of a two-day conference, "Haematology ... Parliament and attended by doctors, researchers, parliamentarians, patients, organisations ...
... Sectra  (NASDAQ OMX Stockholm: SECT B) has ... NYSE: PHG). Philips will pay EUR 57.5 million in a ... operation today, September 1, 2011. "The deal ... continue our efforts and expand our business. In Medical Systems, ...
... Verenium Corporation (Nasdaq: VRNM ), ... and commercialization of high-performance enzymes, today announced James Levine, ... upcoming conferences. Mr. Levine will present at ... on Monday, September 12, 2011.  The presentation is expected ...
Cached Biology Technology:Crucial Directives Must be Revised to Protect Patients' Interests and Improve Access to Treatment 2Sectra and Philips Complete Modality Transaction 2Sectra and Philips Complete Modality Transaction 3Verenium to Present at Upcoming Conferences 2Verenium to Present at Upcoming Conferences 3