Navigation Links
Mechanical forces driving breast cancer lead to key molecular discovery
Date:3/27/2014

ls. The miR-18a dials down the levels of a protective, tumor-suppressing protein called PTEN, which often is disabled in cancerous cells, leading to abnormal biochemical signaling that can promote cancer growth.

Stiffening of the tissue microenvironment in tumors

Weaver is a trained biochemist, and has been a trailblazer in the study of tissue mechanics and cancer for 15 years. Mouw is a mechanical engineer. The newly reported UCSF discovery highlights the importance of mechanical forces in the development of cancer, which usually is thought of in biochemical terms.

Armed with modern lab techniques, Weaver has made many discoveries about the mechanical and structural properties of tumor tissue and the stiffening that can occur. For example, she was the first to identify the cross-linking of structural elements within the ECM as a precursor to cancer progression.

Her research team's latest findings are of clinical interest because they may lead to earlier identification of certain difficult-to-treat breast cancers. About 60 percent of breast cancers can be easily identified as a type known as luminal breast cancer, but there are two subtypes of luminal breast cancer that are difficult to distinguish.

Luminal A breast cancer accounts for about 40 percent of all breast cancers, while luminal B breast cancer comprises about 20 percent. On average, women with luminal B breast cancer do not survive as long after treatment without breast cancer recurring, and they are less likely to respond to hormone therapies such as tamoxifen. Lack of a good diagnostic tool results in overtreatment of many luminal A breast cancers, Weaver said.

According to Shelley Hwang, MD, PhD, chief of breast surgery at Duke University Hospital, former UCSF faculty member and a clinical collaborator for the Nature Medicine study, "Current methods for distinguishing luminal A breast cancer from luminal B breast cancer are expensive and t
'/>"/>

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer cant hide; better heart shocks; mechanical leeches
2. Northwestern researchers examine mechanical bases for the emergence of undulatory swimmers
3. Biomechanical performances of old-fashioned leather and modern football helmets
4. Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
5. Deep inside the body, tiny mechanical microscope
6. Force of nature: Defining the mechanical mechanisms in living cells
7. Mechanical properties and microstructure of cranial and beak bones of the woodpecker and the lark
8. Europe is joining forces against neglected parasitic diseases
9. Crop-infecting virus forces aphids to spread disease
10. Patients and scientists join forces to tackle Friedreichs Ataxia
11. ORNL study uses neutron scattering, supercomputing to demystify forces at play in biofuel production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... MOUNTAIN VIEW, Calif. , Aug. 5, 2015 /PRNewswire/ ... it exhibits continuous growth in applications, penetration into newer ... year after year. The global biosensors space has seen ... having exited the market so far. (Photo ... from Frost & Sullivan, Analysis of the Global ...
(Date:8/3/2015)... Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... today announced that members of the executive management team ... Crest Global Technology Leadership Forum on Tuesday, August 11, ... be held at the Sonnenalp Resort in ... may include forward-looking information. An audio webcast of the ...
(Date:7/31/2015)... de julho de 2015 A 10 a. ... será realizada pela BGI de 22-25 de outubro de 2015, ... A conferência está celebrando seu 10 o. aniversário ... se tornou uma das reuniões mais influentes do mundo ... mais dinâmicos, entusiastas e prazerosos. A ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... Gel-like material shows promise as oral insulin pill for diabetes, ... a gel-like material that could help speed the long-awaited arrival ... mouth, rather than with injections. The study is scheduled for ... In the report, Nicholas A. Peppas and colleagues point ...
... young male offspring who suffer a dominant mother, a brother ... And all because of follicular testosterone. A growing body of ... females conceive more sons. Grant et al., in an article ... of Reproduction , find that the sex of bovine embryos ...
... Shelbyville Police Department, WALL, N.J., March ... BKYI), a leader in finger-based biometric,identification and ... of a contract from the Shelbyville, IN ... data system. Using,MobileCop(TM) software, BIO-key,s wireless messaging ...
Cached Biology News:American Chemical Society's Weekly PressPac -- April 16, 2008 2American Chemical Society's Weekly PressPac -- April 16, 2008 3American Chemical Society's Weekly PressPac -- April 16, 2008 4American Chemical Society's Weekly PressPac -- April 16, 2008 5American Chemical Society's Weekly PressPac -- April 16, 2008 6American Chemical Society's Weekly PressPac -- April 16, 2008 7American Chemical Society's Weekly PressPac -- April 16, 2008 8Biology of Reproduction highlights 2BIO-key(R) Receives New Mobile Data Contract Award From Indiana Police Agency 2BIO-key(R) Receives New Mobile Data Contract Award From Indiana Police Agency 3
(Date:9/1/2015)... ... September 01, 2015 , ... Industry leader iLab Solutions ... In this newly-created position, Gibbs will lead iLab’s business operations in the region, ... tools. This entails not only introducing iLab to potential partners but support and ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... of California Los Angeles, Boston University School of Medicine, Frederick National Laboratory for ... One, the world’s first multidisciplinary Open Access journal. , Christopher Ryan PhD, ...
(Date:9/1/2015)... 1, 2015 Shire plc (LSE: SHP, ... Mathew to its Board of Directors as a Non-Executive ... Compliance & Risk Committee of the Shire Board. Both appointments ... Sara previously served as Chairman, President and Chief Executive Officer ... During her 12-year tenure at D&B, she helped drive the ...
(Date:8/31/2015)... , Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... $5.7 million. The orders are for air emission abatement projects in ... note is a large order for a municipality in the ... be replacing a competitor,s system that failed to meet the ... engineered solutions," said Derek S. Webb , President and ...
Breaking Biology Technology:iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Shire Appoints Sara Mathew to Board of Directors 2
... Terumo Heart, Inc. announced,today that five patients have ... an important early milestone in the U.S.,Pivotal Trial. ... the five implants,at the University of Michigan Cardiovascular ... performed off-pump., "We congratulate Dr. Pagani on ...
... in Kentucky, Indiana,Tennessee, Georgia, Alabama, Ohio and West ... Instruments Inc.,announced that it has appointed Laboratory Supply ... Tennessee, Georgia,Alabama, Ohio and West Virginia. LABSCO, the ... the United States, will sell,Nikon,s market leading i-Series ...
... Awards to Honor Outstanding Healthcare Providers, LEXINGTON, ... its "Passion & Results" award, and is now ... laboratorians,physicians and nurses who have demonstrated true passion ... to enhance the quality of,patient care. Three winners ...
Cached Biology Technology:Fifth DuraHeart(TM) U.S. Implant Marks Important Milestone in U.S. Pivotal Trial 2Nikon Instruments Appoints LABSCO its Clinical Distributor in Six States 2Instrumentation Laboratory Announces 'Passion & Results' Awards Program 2
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Guava has made microcapillary flow cytometry accessible ... experts alike will appreciate the latest addition ... Pluseasy to use, surprising affordable, and very ... system includes such features as absolute cell ...
...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Biology Products: