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Measuring the number of protein molecules inside cells
Date:7/18/2014

o ensure the faithful transmission of chromosomes to the daughter cells during cell division. When cells divide, the CENP-A proteins are distributed to the daughter cells, and the number of molecules that each cell receives may vary. By having 400 molecules the cell can assure that a sufficient number of CENP-A is passed to form the centromeres. The calculation of the number of CENP-A molecules allows us to propose a mechanistic framework that can explain the formation and inheritance of centromeres".

When asked about the technical difficulties faced during this study Lars says: "We took 5 years to conduct this work, and for sure we would not be able to have done it 10 years ago. We need to develop new techniques continuously to be able to go further and answer novel questions, even to old biological problems. We have arrived at a time in biology where more and more laboratories will start looking at the quantitative aspects of the biological problem they are studying. The techniques we have employed can be quite helpful for that."


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Contact: Ana Mena
anamena@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

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