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Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer
Date:10/27/2013

to track the presence of papillary thyroid cancer by a microRNA blood test," said Lee. Dr. Lee added that the current blood test for the detection of recurrent papillary thyroid cancer is not accurate in up to a quarter of patients either because of interference from the patients' antibodies or other cancer-related factors. "Therefore, an alternative blood test measuring microRNA levels would be a great complement to what is already available," he said. Blood levels of the microRNAs may not be a good initial diagnostic tool for papillary thyroid cancer, though, because study participants with multinodular goiter, which is a common non-cancer thyroid condition, also had elevated levels in their blood. Also, the specific threshold miRNA level at which additional treatment would be warranted remains to be clarified.

Follow-up studies are needed to see if blood levels of microRNA-222 and microRNA-146b actually do increase when cancer recurs. Also, the accuracy of both testsperformed on tumors and on blood samplesneeds to be improved before the tests can become clinically useful.


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Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

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