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Measuring molecules to improve drug design
Date:2/6/2009

C microscopy is an improvement on an older technology, called FRET, which can measure distances from 1-10 nanometres. DAC can measure 1-250 nanometres, giving a more complete picture of drug-membrane receptor interactions. It will complement other techniques like X-ray crystallography.

The DAC software was tested using fluorescent polystyrene microspheres only 100 nm across about one thousandth the width of a hair.

"We are currently looking at more samples that require the ability to see single molecules with very high contrast. Results are extremely encouraging and we are starting to explore commercial possibilities," Dr Vallotton says.


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Contact: Carrie Bengston
Carrie.Bengston@csiro.au
61-293-253-224
CSIRO Australia
Source:Eurekalert

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