Navigation Links
Measuring molecules to improve drug design
Date:2/6/2009

CSIRO has patented an improved microscopy method for measuring the shapes and sizes of proteins which could help scientists create new pharmaceuticals that are a better match for the proteins they target.

The method, called Differential Aberration Correction (DAC) microscopy, measures distances at the molecular level in two and three dimensions using conventional fluorescence microscopy.

A special feature of the new method, written up recently in the Journal of Microscopy, is that it allows scientists to measure proteins in solution, which is how they exist in nature, instead of using coated or crystallised proteins as other techniques do. This is particularly important for rational drug design but has broader life sciences applications.

The leader of CSIRO's Biotech Imaging team, Dr Pascal Vallotton, says DAC microscopy measures distances a million times smaller than a tape measure can in nanometres rather than millimetres. One nanometre is one billionth of a metre.

"Just as a tailor measures up a person for a suit, we want to use our technique to measure accurate dimensions of proteins called membrane receptors," Dr Vallotton says.

"These proteins sit on cell boundaries, acting as gate-keepers, and they represent a class of biomolecules targetted by over 50 per cent of pharmaceuticals.

"Understanding the complex structures of these molecules and how new drugs affect their structure will help drug companies design more effective pharmaceuticals."

Cells are often viewed using conventional fluorescence microscopy. However, images obtained this way are inaccurate because light is bent differently for different wavelengths through the microscope. Several universities have attempted complex and onerous hardware-based solutions to try to fix this problem.

CSIRO researchers instead used a software-based approach that precisely corrects the distortion at every point in the image.

DA
'/>"/>

Contact: Carrie Bengston
Carrie.Bengston@csiro.au
61-293-253-224
CSIRO Australia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Atmospheric measuring device for understanding smog formation
2. Positron emission tomography superior to standard evaluation tools in measuring treatment response
3. New approach to measuring carbon in forests
4. Biosensor for measuring stress in cells
5. Measuring the stress of forested areas
6. Measuring calcium in serpentine soils
7. Measuring water from space
8. Clemson scientists shed light on molecules in living cells
9. New molecules discovered that block cancer cells from modifying cell DNA
10. Curry-derived molecules might be too spicy for colorectal cancers
11. New book presents methods to poke and prod individual molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced a new implementation of its ... rapid and secure transactions and reliable identification for ... a turnkey solution providing mouse and keyboard peripheral ... fingerprint ID solutions into their product offerings, bringing ...
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/24/2015)... 24, 2015 Research and Markets ... the "Global 2D Gesture Recognition Market 2015-2019" ... The analysts forecast the Global 2D Gesture Recognition ... over the period 2014-2019 The increased ... is one of the major trends in the ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2
... Researchers at the Johns Hopkins University School of Medicine ... human brain cancer cells using nanoparticles that can be ... to use. The shelf-stable particles may obviate the need ... safety concerns. The report appears in the August issue ...
... study of over 50 000 pregnancies revealed that women ... gave birth to babies with a similar birthweight to ... Nick Macklon, from the Department of Obstetrics and Gynaecology, ... the European Society of Human Reproduction and Embryology today ...
... the University of Maryland School of Medicine have found ... eats plant material cellulose at temperatures near ... the microbe,s cellulose-digesting enzyme, called a cellulase, is most ... Fahrenheit), significantly above the 100oC (212oF) boiling point of ...
Cached Biology News:Just add water and treat brain cancer 2Giving up smoking averts the adverse birth outcomes associated with tobacco 2Hot springs microbe yields record-breaking, heat-tolerant enzyme 2Hot springs microbe yields record-breaking, heat-tolerant enzyme 3
(Date:3/5/2015)... DIEGO and TORONTO , ... TSX: APS), a clinical-stage company developing new therapeutics and ... today announced that William G. Rice , Ph.D., ... the upcoming 27th Annual ROTH Conference on Tuesday, March ... The Ritz Carlton, Laguna Niguel, CA. ...
(Date:3/5/2015)... The next implants made from the ... mark (European) approval. The CE mark is necessary for ... and the European Union. Following the Class IIb approval ... implants supplied by the Turkey-based company Osimplant for the ... Cervical Expandable Bladed HA PEEK Cage line of spinal ...
(Date:3/4/2015)... , March 4, 2015  Brooklyn residents now have ... and chronic pain and injuries. Nunzio Saulle , ... grand opening of his NJS Physical Medicine and Rehabilitation ... on Thursday, March 5, 2015. Health Plus Management, LLC ... is located at 1178 Flatbush Avenue. This new PM&R ...
(Date:3/4/2015)... 2015 PRC Clinical, a ... Francisco Bay Area, will exhibit and present at the ... on March 25th and 26th in Tel Aviv, ... with Israeli life science companies seeking to conduct U.S. ... services span all phases of human trials, from Phase ...
Breaking Biology Technology:Aptose Biosciences to Present at the 27th Annual ROTH Conference 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 3Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 3NJS Physical Medicine & Rehabilitation Opening on Flatbush Avenue, Brooklyn, NY 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 4
... has discovered and characterized a promising chemically modified Vitamin ... In animal studies, 2MD increases bone growth while leaving ... times the level of other compounds. , ,According to ... levels in the blood. Too little calcium can cause ...
... MADISON - A veteran television reporter recently asked me to ... expect to find jobs after they complete their education. The ... know, I would invest every penny I have in those ... Labor Day passes in Wisconsin, the question about jobs for ...
... MADISON, WI - The U.S. Department of Health and ... Regional Centers of Excellence (RCE) for Biodefense and Emerging ... with 11 other Midwestern institutions to form the Midwestern ... The Midwestern center, based at the University of Chicago ...
Cached Biology Technology:Biotech Pioneer Discusses Breakthrough in Osteoporosis Treatment 2Heres how todays Wisconsin children will find jobs tomorrow 2Heres how todays Wisconsin children will find jobs tomorrow 3UW-Madison Gets Federal Biodefense Funds 2
... 45° Fixed Angle Rotor ... Centra CL2, Centra CL3CL3R, and ... concentration of sputum samples and ... samples. Provides individual aerosol containment. ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
Biology Products: