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Measuring life's tugs and nudges
Date:12/9/2013

formed each droplet was, the scientists could precisely calculate the force exerted on it by the neighboring cells adhering to it and by the extracellular matrix.

Using the new method, the scientists were able to quantitate the forces within lab-grown 3D aggregates of mouse mammary tumor cells, and within living 3D tissues from embryonic mouse jaws. They found that an individual cell exerted huge forces 24 times as much pressure on the droplet as the jaws of an ant and that the cells exerted the same amount of force in cultured aggregates as in tissues, lending confidence to the method's accuracy.

In his new lab at UCSB, Camps now uses the method to determine the spatial patterns of forces that shape different embryonic structures in fish, chicken, and other organisms.


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Contact: Dan Ferber
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

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