Navigation Links
Measuring life's tugs and nudges
Date:12/9/2013

BOSTON As embryonic tissue develops, cells push and pull on each other, and they must do so correctly for the tissue to develop properly. Now scientists at Harvard University have devised the first method to measure these forces in three-dimensional (3D) tissues and living embryos.

The method, which involves injecting tiny oil droplets, could lead to new tools to diagnose cancer, hypertension, connective tissue diseases, and more. Scientists from the Wyss Institute for Biological Engineering at Harvard University and the Harvard School of Engineering and Applied Sciences (SEAS) reported the work online December 8 in Nature Methods.

"Now that we can quantitate cellular forces, we can find entirely new ways to diagnose the extraordinarily wide range of diseases that alter cell contractility and tissue stiffness," said Don Ingber, M.D., Ph.D., Founding Director of the Wyss Institute, Professor of Bioengineering at SEAS, and senior author of the study. "Just as important, we can answer crucial questions about development that have lay dormant for decades."

Biological tissues don't just sit there inside the body they are constantly in motion, with cells tugging on and nudging other cells and the extracellular matrix the molecular scaffold that knits cells together into tissues. As a result, tissues live in a state of dynamic tension, like a partially stretched rubber band.

Studies in lab-grown cells suggest that mechanical forces are as important in regulating biological function as chemicals and genes. But scientists had no way of studying those control mechanisms in developing embryos because they had no way of quantifying mechanical forces at specific positions in living tissues.

Such forces are particularly important as the body develops from the fertilized egg into tissues and organs with specialized shapes and functions a process known as morphogenesis. Biologists studying morphogenesis knew that as the embryo develops, me
'/>"/>

Contact: Dan Ferber
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer
2. Measuring blood sugar with light
3. New technique for measuring tree growth cuts down on research time
4. Measuring microbes makes wetland health monitoring more affordable, says MU researcher
5. Measuring ultrasound for better treatment of muscle injuries
6. Measuring mercury: Common test may overestimate exposure from dental amalgam fillings
7. A new method for measuring the flow of traffic a street has to bear by measuring atmospheric noise
8. New tool for measuring frozen gas in ocean floor sediments
9. New protocol recommendations for measuring soil organic carbon sequestration
10. Measuring the exertion of mini-basketball players
11. Measuring dispersal -- how well are soft-sediment invertebrate communities connected on the seafloor?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Measuring life's tugs and nudges
(Date:5/18/2015)... GOTHENBURG, Sweden , May 18, 2015 ... touch fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from ... place from June until and including Q3 2015 and the ... Asia . Communicated order values for 2015 hereby amount ... revenues for Q1 2015 of 140 MSEK and a number ...
(Date:5/11/2015)... Curemark LLC, a privately held drug research ... Phase III double blind, randomized, placebo-controlled clinical trial to ... all children ages 3-8 with Autism. Previously, Curemark announced ... blinded clinical trial for CM-AT in children ages 3-8 ... enzyme chymotrypsin. This new trial will help determine whether ...
(Date:5/5/2015)... Conn. , May 5, 2015, NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, reminds ... Company,s Chief Technology Officer, is presenting  at CARTES SECURE CONNEXIONS ... May 5-7, 2015. The three-day conference is ... David is speaking in is themed Global Fraud: Where ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... in understanding how plants pass signals of stress due ... nucleus. They know that chloroplasts ?the cellular organelles that ... different signals that can indicate a plant is under ... facing over the coming decades through global warming, this ...
... Gore's film, An Inconvenient Truth, has generated greater awareness ... more rapid warming that has occurred within major cities. ... degrees hotter than their surroundings. These metropolitan hot spots, ... stress the animals and plants that make their home ...
... international group of scientists has announced a major ... the activities of genes in living organisms. ... to describe the complex events that occur when ... Understanding these events is crucial for developing new ...
Cached Biology News:Discovery of 'master switch' for the communication process between chloroplast and nuclei of plants 2Discovery of 'master switch' for the communication process between chloroplast and nuclei of plants 3City ants take the heat 2Uniform language for describing genes of pathogenic and beneficial microbes 2Uniform language for describing genes of pathogenic and beneficial microbes 3
(Date:6/2/2015)... , June 02, 2015 Research ... of Jain PharmaBiotech,s new report "Biomarkers - ... This report follows the broad definition ... be objectively measured and evaluated as an indicator ... as pharmacological responses to a therapeutic intervention. Tests ...
(Date:6/2/2015)... 2015 Cirrascale Corporation ®, ... rackmount computing and storage infrastructure for conventional and ... its high density scale-out, two-in-one video delivery and ... . The high density, two-in-one system supports the ... with Intel® Iris™ Pro graphics P6300 and provides ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 “Stem Cell Therapy ... more mainstream, and it is used often as an adjunct ... general practitioners are not yet aware or comfortable enough with ... therapy is most often reserved for the last resort cases ... pet can barely lift a paw to get around. It ...
(Date:6/2/2015)... 2, 2015   Sigma-Aldrich Corporation (NASDAQ: ... company, announced today it has entered into an ... genetically engineered human neural differentiated cells and accompanying ... neurological diseases. These new products, in combination with ... tools for the study of central nervous system ...
Breaking Biology Technology:Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 2Global Biomarkers Market Report 2015 - Technologies, Markets and Companies Analysis and Forecasts 2014-2024 3Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 2Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 3VetStem Biopharma, Proudly Announces a New Long Term Partnership with VCA West Los Angeles in Support of Stem Cell Therapy Training and Clinical Opportunities. 2VetStem Biopharma, Proudly Announces a New Long Term Partnership with VCA West Los Angeles in Support of Stem Cell Therapy Training and Clinical Opportunities. 3Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3
... The Wisconsin Department of Commerce has announced ... Wisconsin businesses for technology development projects. , ,NovaScan, a ... of materials used to identify different tissue types, will ... develop and test a prototype for clinical application of ...
... adison, Wis. - So you want to ... business! Where do you begin? , ,The idea usually comes ... an employee, or forming a business entity, protecting this commercial ... , ,But what type of intellectual property is this? ...
... the Health Insurance Portability and Accountability Act (HIPAA) ... can understand that since I am a practicing dentist with ... at stake. I am what they call a "stakeholder" in ... , ,More important than my job, I am a ...
Cached Biology Technology:Starting a tech business? Step 1 is minding the intellectual property 2Starting a tech business? Step 1 is minding the intellectual property 3Careful with that electronic health record, Mr. Leavitt 2Careful with that electronic health record, Mr. Leavitt 3Careful with that electronic health record, Mr. Leavitt 4
Lipofectin Reagent is the reagent of choice for some cell lines; cells of endothelial derivation transfect well with Lipofectin Reagent....
Request Info...
... Clone/PAD: 5B15-5B-11E. Immunogen: Synthetic peptide derived ... MUC5B protein. Specificity: Specific for ... On Western blots it identifies the target ... Human (positive controls: deglycosylated secreted media from ...
Lipid-rich bovine serum albumin for cell culture. It is chromatographically purified and has an IgG content 1.0% (w/w)....
Biology Products: