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Measles virus plays role in Paget's disease of bone, Pitt-led team says
Date:1/14/2011

ponses. Osteoclasts appeared normal, though, when the precursor cells came from PD patients who didn't make MVNP.

"It's not clear why this would happen," Dr. Roodman said. "It could be that other viruses or genes are triggering PD in these patients."

Mice with a p62 gene mutation and MVNP developed dramatic bone lesions. Other tests indicate that the presence of MVNP increases production of the cell-signaling protein interleukin-6, which in turn leads to osteoclast changes that are seen in PD.

The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles vaccination or that another environmental factor involved in PD has changed.


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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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