Navigation Links
Measles virus plays role in Paget's disease of bone, Pitt-led team says
Date:1/14/2011

PITTSBURGH, Jan. 14 A gene from the measles virus plays a key role in the development of Paget's disease of bone, according to a team of researchers led by the University of Pittsburgh School of Medicine. Their findings, recently published in Cell Metabolism, confirm a long-held speculation that the childhood infection is an environmental trigger for the disease and reveal how the viral gene contributes to the development of its characteristic bone lesions.

"Our earlier work showed that bone cells called osteoclasts in about 70 percent of these patients contain a certain measles virus protein," noted senior investigator, G. David Roodman, M.D., Ph.D., professor and vice chair for research, Department of Medicine. "Also, when we engineered normal osteoclasts in mice to contain, or express, the measles protein, pagetic bone lesions formed."

Osteoclast abnormalities lead to imbalance in the normal processes of bone dissolution and rebuilding. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, an estimated 1 million Americans have Paget's disease (PD) of bone. Bones are enlarged but fragile, leading to pain and a greater likelihood of fracture. Arthritis, hearing loss and kidney stones can occur.

In the new study, Dr. Roodman's team sought to understand the roles of mutations in a gene called p62, which is common among PD patients, and measles virus nucleocapsid protein (MVNP) by examining the marrow of affected and unaffected bones of 12 PD patients and of eight people without PD. They also bred mice with the p62 mutation and MVNP.

The team found that marrow from eight of the 12 PD patients expressed MVNP; three patients expressed the protein in both affected and unaffected bone sites, and four patients did not make it at either type of site. Osteoclast precursor cells from PD patients who made MVNP formed pagetic osteoclasts in test tube experiments and displayed other typical PD responses. Osteoclasts appeared normal, though, when the precursor cells came from PD patients who didn't make MVNP.

"It's not clear why this would happen," Dr. Roodman said. "It could be that other viruses or genes are triggering PD in these patients."

Mice with a p62 gene mutation and MVNP developed dramatic bone lesions. Other tests indicate that the presence of MVNP increases production of the cell-signaling protein interleukin-6, which in turn leads to osteoclast changes that are seen in PD.

The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles vaccination or that another environmental factor involved in PD has changed.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related biology news :

1. Measles virus, a weapon against cancer?
2. Mayo researchers describe measles viral protein movement
3. Virus killer gets supercharged
4. Scripps Research scientists identify key interaction in hepatitis C virus
5. Movement and threat of RNA viruses widespread in pollinator community
6. New research shows virus previously linked to chronic fatigue syndrome is a lab contaminant
7. Scientists identify how virus triggers cervical and mouth cancer
8. Ph.D. thesis describes 35 hitherto unknown families of endogenous retroviruses
9. Virus component helps improve gene expression without harming plant
10. Chimerix Antiviral CMX001 Inhibits JC Virus Replication in Preclinical Study; Late-Breaker Presented at Antiviral Congress 2010
11. UNC scientists identify cellular communicators for cancer virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... , March 3, 2016  2016FLEX, organized by ... week highlighting advancements in flexible, hybrid and printed ... setting attendance - have gathered for short courses, ... field of electronics. The Flex Conference celebrates its ... for companies, R&D organizations, and universities contributing to ...
(Date:3/2/2016)... DUBLIN , March 2, 2016 /PRNewswire/ ... has announced the addition of the  "Global ... to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... sector to grow at a CAGR of ... http://www.researchandmarkets.com/research/wzwqtz/global_biometrics ) has announced the addition ...
(Date:3/1/2016)... March 1, 2016 ... addition of the  "Global Biometric Access ... to their offering. --> ... of the  "Global Biometric Access Control ... their offering. --> Research ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... CAMBRIDGE, Mass. (PRWEB) , ... April 26, 2016 , ... ... Herr has been selected as one of three finalists for the European Inventor ... the EPO’s annual innovation prize will be announced at a ceremony in Lisbon on ...
(Date:4/26/2016)... , ... April 26, 2016 , ... Mr. Palmer created ... RPO, signing the first multi-million dollar, multi-year managed services contract in the U.S. intelligence ... Michael join our leadership team,” said John Younger, founder of Accolo. “We are ...
(Date:4/26/2016)... , ... April 26, 2016 , ... BioFactura, Inc ... Series A round of financing. Healthy investor interest drove significant oversubscription of the ... generic biologics, known as biosimilars, to the advanced preclinical stages. , Chief Executive Officer ...
(Date:4/26/2016)... , VIENNA and ... -- The prize recognizes the innovation ... revolutionary innovations that will benefit patients and laboratory ... ) , Norma Instruments ... trend setting products in the field of hematology, ...
Breaking Biology Technology: