Navigation Links
Measles virus, a weapon against cancer?
Date:1/12/2011

measles infection," said UTMB professor Werner Braun, an author of the study. "We have a long-standing collaboration with his group, using our theoretical predictions and computational methods to help them better target their experimental work."

UTMB Health research scientist Numan Oezguen used computer-based molecular modeling to predict interaction sites and suggested specific mutations that would alter the interaction and mobility of the attachment protein heads. Results of these experiments performed by the Mayo Clinic team led by Cattaneo showed that cell entry of the measles virus depends on a twisting motion of the attachment protein's heads.

To produce an accurate portrait of the dynamic mechanism the Mayo Clinic group created measles viruses with mutations affecting the mobility of their attachment protein heads, and then tested the mutated viruses to determine each type's ability to infect cells. "What Dr. Cattaneo's experiments showed was that the motion of these two parts of the attachment protein has a dramatic effect on infectivity," Braun said. "In a simplified sense, we think this works like a lever if the cell receptors pull on the attachment protein properly, they generate this type of motion, and this triggers the fusion protein and leads to infectivity."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-6397
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Mayo researchers describe measles viral protein movement
2. Researchers recreate SARS virus, open door for potential defenses against future strains
3. Hepatitis C virus faces new weapon from Florida State scientists
4. New medical weapons to protect against anthrax attacks
5. Understanding robustness in organisms -- a potential weapon against infectious diseases
6. Atrazine is the main weapon against weeds in sweet corn, with few alternatives
7. Multifunctional polymer neutralizes both biological and chemical weapons
8. UCF professors vaccine could be lethal weapon against malaria, cholera
9. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
10. Researchers identify potential new weapon in battle against HIV infection
11. Control of blood vessels a possible weapon against obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 ResearchMoz ... Government Biometric Systems Market 2014-2024   Business Strategies, Industry ... Biometric Systems Market 2014-2024" offers the reader detailed ... the next ten years, alongside potential market opportunities ... forecasts. To view the table of ...
(Date:7/30/2014)... shrinking ranges and a changing climate threaten some ... plants, and so conservationists establish seed collections to ... in hopes of preserving some genetic diversity., For ... simple models that offer a one-size-fits-all approach for ... saving 50 seed samples regardless of species, pollination ...
(Date:7/30/2014)... humans figured out how to create colors, nature had ... wings of many different hues, for example. Now scientists ... environmentally friendly way to make colored plastics. Their paper ... of materials rather than dyes, to produce color ... , N. Asger Mortensen, Anders Kristensen and colleagues point ...
Breaking Biology News(10 mins):Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10Saving seeds the right way can save the world's plants 2
... prey. The tentacled snake from South East Asia has developed ... a way to startle its prey so that the fish ... away. In addition, the fish,s reaction is so predictable that ... the fish,s head will be instead of tracking its actual ...
... ANN ARBOR, Mich. It,s common knowledge that a ... tracts. Antibiotics at least temporarily disturb the normal balance. ... and if the full array of "good bacteria" return ... In studies in mice, University of Michigan scientists have ...
... Kingston, ON A new approach to tracking ... more light on the potentially endangered Arctic animal and ... Integrating the traditional knowledge of Inuit hunters with state-of-the-art ... Peter V.C. de Groot and Peter Boag, is cheaper ...
Cached Biology News:Discovery of a water snake that startles fish in a way that makes them flee into its jaws 2Discovery of a water snake that startles fish in a way that makes them flee into its jaws 3Antibiotics take toll on beneficial microbes in gut 2Antibiotics take toll on beneficial microbes in gut 3New tracking approach will help protect polar bears 2
(Date:7/30/2014)... 2014  Replikins Ltd. today released new data on ... Before the current outbreaks, the mean Ebola Reston gene ... between 1995 and 2002 was 1.1; the mean Replikin ... sixteen-fold in 2013, thus predicting the current outbreaks in ... been shown to be able to predict outbreaks (1). ...
(Date:7/30/2014)... 2014   Wyle has been named ... Mission Support Services (FILMSS) contract awarded by the ... terms of the contract, Wyle will provide mission ... Calif. In particular, Wyle will provide program and ... on the International Space Station and collaborative science ...
(Date:7/30/2014)... Vycom announces the addition of Thermax PVC to ... Mutual (FM) 4910 fire propagation and smoke generation criteria ... tools, fume hoods, furniture and cabinetry. These criteria reduce ... used in electronic chip manufacturing. , Flametec ... workability and superior aesthetics. It is available in a ...
(Date:7/30/2014)... , July 30, 2014 Researchers often ... interrogate biology, but such devices can do much ... As such, researchers have looked to patterned ... vitro metabolic engineering to characterize – and ... New devices are envisioned to recreate animal and ...
Breaking Biology Technology:Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4
... PRGO ; TASE) announced today that Joseph ... Merrill Lynch Global Pharmaceutical,Biotechnology and Medical Device Conference ... the Grand Hyatt Hotel in New York., ... that develops,manufactures and distributes over-the-counter (OTC) and prescription,pharmaceuticals, ...
... 5 CardioTech,International, Inc. (Amex: CTE ), ... devices for the treatment of cardiovascular and other,diseases, ... 2008 third,quarter financial results before the market opens ... Company will host a conference call for,investors at ...
... PRINCETON, N.J., Feb. 5 Celator Pharmaceuticals today,announced ... scheduled,to present on the company,s business operations and ... Organization (BIO) CEO,and Investor Conference on Tuesday, February ... New York City., About Celator, Celator ...
Cached Biology Technology:CardioTech Announces Conference Call on February 12 at 2:30 PM Eastern for Third Quarter of Fiscal 2008 2
... the value of your microarray data ... the support you need from consultation ... most up to date methods. Utilize ... Gene Expression Profiling Service or from ...
... of your microarray data using Asuragens bioinformatics ... from consultation to extensive data analysis using ... our expertise in combination with the Gene ... microarray experiments., ,Normalization and basic statistical analysis ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. Material: cap ...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap, packed in double bag. (20/ca) Packaging: ...
Biology Products: