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Measles virus, a weapon against cancer?
Date:1/12/2011

measles infection," said UTMB professor Werner Braun, an author of the study. "We have a long-standing collaboration with his group, using our theoretical predictions and computational methods to help them better target their experimental work."

UTMB Health research scientist Numan Oezguen used computer-based molecular modeling to predict interaction sites and suggested specific mutations that would alter the interaction and mobility of the attachment protein heads. Results of these experiments performed by the Mayo Clinic team led by Cattaneo showed that cell entry of the measles virus depends on a twisting motion of the attachment protein's heads.

To produce an accurate portrait of the dynamic mechanism the Mayo Clinic group created measles viruses with mutations affecting the mobility of their attachment protein heads, and then tested the mutated viruses to determine each type's ability to infect cells. "What Dr. Cattaneo's experiments showed was that the motion of these two parts of the attachment protein has a dramatic effect on infectivity," Braun said. "In a simplified sense, we think this works like a lever if the cell receptors pull on the attachment protein properly, they generate this type of motion, and this triggers the fusion protein and leads to infectivity."


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Contact: Jim Kelly
jpkelly@utmb.edu
409-772-6397
University of Texas Medical Branch at Galveston
Source:Eurekalert

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