Navigation Links
McMaster study unveils lifeline for 'antibiotic of last resort'
Date:4/11/2010

Hamilton, ON (April 9, 2010) A new study led by the scientific director of the Michael G. DeGroote Institute for Infectious Disease Research has uncovered for the first time how bacteria recognize and develop resistance to a powerful antibiotic used to treat superbug infections.

Gerry Wright, a professor in the Department of Biochemistry and Biomedical Sciences at McMaster University in collaboration with colleagues at the John Innes Centre in Norwich, and the University of Cambridge in the UK, have identified the specific mechanism that triggers resistance to vancomycin.

The discovery reveals new understanding about what is happening at the molecular level in vancomycin resistance. It also represents an essential first step in developing new antibiotics that can evade the sensing mechanism of bacteria and overcome resistance.

The research, funded in part by the Canadian Institutes of Health Research and the Canada Research Chairs program, will be published online in the high-impact journal Nature Chemical Biology on April 11, 2010.

"Vancomycin is the antibiotic of last resort and is only given when all other treatments fail," said Wright, who holds the Canada Research Chair in Molecular Studies of Antibiotics and an endowed research Chair in Infection and Anti-Infective Research.

"For years it was thought that resistance would be slow to emerge since vancomycin works in an unusual way. But with the widespread use of the drug to treat infections caused by the hospital superbug MRSA, it has become a serious clinical problem."

MRSA is the short-form for methicillin-resistant staphylococcus aureus, a bacterial infection that is highly resistant to some antibiotics. MRSA bacteria are responsible for a large percentage of hospital-acquired staph infections, but may also be acquired in the community.

Vancomycin is used to treat enterococcal infections that develop in patients following abdomina
'/>"/>

Contact: Susan Emigh
emighs@mcmaster.ca
905-518-3642
McMaster University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research network at McMaster aims to build a better eye
2. McMaster researchers discover new mode of how diseases evolve
3. McMaster University engineering professor receives Humboldt Research Award
4. FSU marine ecologist wins grant to study endangered sawfish
5. Pitt-led international study identifies human enzyme that breaks down potentially toxic nanomaterials, opens door to novel drug delivery
6. Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials
7. BUSPH study links rheumatoid arthritis to vitamin D deficiency
8. 4,000-year study supports use of prescribed burns in Southern Appalachians
9. New study shows rising water temperatures in US streams and rivers
10. MSU leads global effort to study link between people, planet
11. Peregrine reports new study from Duke shows anti-HIV potential of targeting PS on cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
(Date:7/10/2014)... , July 1, 2014 Smart ... way for convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), ... GOOG ), Apple Inc. (NASDAQ: AAPL ... Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric ... to announce that the second series of 30 second spots ...
(Date:7/10/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ) ... Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, ... report to their offering ... Touch-Less Sensing Market to Grow Exponentially. Touch-less sensing ... the companies were unable to leverage this technology ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... change the world has seen in the last 100,000 years ... interglacial period. New research from the Niels Bohr Institute at ... the rise in temperature and the rise in the atmospheric ... time. The results have been published in the scientific journal, ...
... new study finds that mice have a distinct neural ... is associated with instinctually important smells such as those ... in Proceedings of the National Academy of Sciences ... have specially hardwired neural circuitry to trigger instinctive behavior ...
... breeders announced a new high-yielding variety of oats. ... height, withstands falling over (lodging), matures earlier and produces ... seed yield potential, exceeding the Rodgers variety by 20 ... 32.2-pound bushel compared to 31.9-pound bushel for Rodgers," said ...
Cached Biology News:Rise in temperatures and CO2 follow each other closely in climate change 2Rise in temperatures and CO2 follow each other closely in climate change 3Mice have distinct subsystem to handle smell associated with fear 2Mice have distinct subsystem to handle smell associated with fear 3Clemson plant breeders roll out new oat variety 2
(Date:7/10/2014)... Calabasas, CA (PRWEB) July 10, 2014 ... academic institutions and professional associations, addressed the challenges of ... & Medical Device Industries” through strategic sourcing. Describing the ... ) with the Supply Chain Management Institute ( SCMI) ... the event on June 24 at the Kroc Institute ...
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
(Date:7/10/2014)... help in the fight against terrorism with the creation ... explosives with the use of light and special glass ... Actuators B: Chemical , the researchers describe a novel ... as low as 6.3 ppm (parts per million). It ... , "Traditionally explosives detection has involved looking for metals ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... New Research Base and First Molecule Discovered by ... Leading global biopharmaceutical company, Ferring Pharmaceuticals, and ... new and expanded, 38,000-square-foot facility located in Sorrento ... further development of peptide research and therapeutics. ...
... CITY, China, Feb. 11 /PRNewswire-Asia-FirstCall/ -- ... CBPO) (,China Biologic, or the,Company,), one ... in the,People,s Republic of China (,PRC,), ... subsidiary, Shandong Taibang Biological Products Co.,Ltd. ...
... Md., Feb. 11 Vanda Pharmaceuticals Inc. (Nasdaq: ... development and commercialization of clinical-stage product candidates for central ... for the fourth quarter ended December 31, 2008. ... the fourth quarter of 2008, compared to $10.9 million ...
Cached Biology Technology:Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 2Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 3Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix 4China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 2China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 3Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 2Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 3Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 4Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 5Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 6Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 7Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 8Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 9Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2008 Results 10
PlusOne Acrylamide PAGE, 1 kg. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Mouse Aminopeptidase P2/XPNPEP2 Affinity Purified PAb Protein Family: Aminopeptidases, Metalloproteases...
... is extensively scrutinized, including negative ... All horses are of U.S. ... are controlled and documented to ... Pricing: $12/unit for ...
Mouse Aminopeptidase P2/XPNPEP2 Biotinylated Aff Pur PAb Keywords: AminopeptidaseP2, Metalloproteinase, Metalloprotease, X-Prolyl Aminopeptidase 2, X-Pro Aminopeptidase 2, Membrane-bound Prote...
Biology Products: