Navigation Links
McMaster study unveils lifeline for 'antibiotic of last resort'
Date:4/11/2010

Hamilton, ON (April 9, 2010) A new study led by the scientific director of the Michael G. DeGroote Institute for Infectious Disease Research has uncovered for the first time how bacteria recognize and develop resistance to a powerful antibiotic used to treat superbug infections.

Gerry Wright, a professor in the Department of Biochemistry and Biomedical Sciences at McMaster University in collaboration with colleagues at the John Innes Centre in Norwich, and the University of Cambridge in the UK, have identified the specific mechanism that triggers resistance to vancomycin.

The discovery reveals new understanding about what is happening at the molecular level in vancomycin resistance. It also represents an essential first step in developing new antibiotics that can evade the sensing mechanism of bacteria and overcome resistance.

The research, funded in part by the Canadian Institutes of Health Research and the Canada Research Chairs program, will be published online in the high-impact journal Nature Chemical Biology on April 11, 2010.

"Vancomycin is the antibiotic of last resort and is only given when all other treatments fail," said Wright, who holds the Canada Research Chair in Molecular Studies of Antibiotics and an endowed research Chair in Infection and Anti-Infective Research.

"For years it was thought that resistance would be slow to emerge since vancomycin works in an unusual way. But with the widespread use of the drug to treat infections caused by the hospital superbug MRSA, it has become a serious clinical problem."

MRSA is the short-form for methicillin-resistant staphylococcus aureus, a bacterial infection that is highly resistant to some antibiotics. MRSA bacteria are responsible for a large percentage of hospital-acquired staph infections, but may also be acquired in the community.

Vancomycin is used to treat enterococcal infections that develop in patients following abdomina
'/>"/>

Contact: Susan Emigh
emighs@mcmaster.ca
905-518-3642
McMaster University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research network at McMaster aims to build a better eye
2. McMaster researchers discover new mode of how diseases evolve
3. McMaster University engineering professor receives Humboldt Research Award
4. FSU marine ecologist wins grant to study endangered sawfish
5. Pitt-led international study identifies human enzyme that breaks down potentially toxic nanomaterials, opens door to novel drug delivery
6. Pitt-led study identifies human enzyme that breaks down potentially toxic nanomaterials
7. BUSPH study links rheumatoid arthritis to vitamin D deficiency
8. 4,000-year study supports use of prescribed burns in Southern Appalachians
9. New study shows rising water temperatures in US streams and rivers
10. MSU leads global effort to study link between people, planet
11. Peregrine reports new study from Duke shows anti-HIV potential of targeting PS on cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... , Oct. 15, 2014 Sandata ... for home and community-based care, today announced it ... implementing Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™) ... is a home health company founded in 1996 ... . The study details ...
(Date:10/15/2014)... rapidly and to an unexpected extent. The outbreak does ... the virus shows a new disease dynamic in regions, ... reason, the German National Academy of Sciences Leopoldina, acatech ... the Union of the German Academies of Sciences and ... today. , In the statement the academies call for ...
(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
... 2011 /PRNewswire-Asia/ -- Clearbridge Accelerator announced today that it ... venture capitalist based in the Silicon Valley. Mr Draper, ... Draper Fisher Jurvetson (DFJ), is well known for making ... Clearbridge Accelerator is a technology incubator that ...
... researchers have developed the first lab-on-a-chip sensor to provide fast ... The sensor is both environmentally and child friendly, and ... a UC researcher is leading a long-term health study on ... University of Cincinnati researchers to create a sensor that provides ...
... of the newest edition of its authoritative reference for ... edition, is available in both print and, for the ... of the Manual of Clinical Microbiology marks a significant ... Editor-in-Chief James Versalovic of Texas Children,s Hospital. "For the ...
Cached Biology News:Singapore Technology Incubator Receives Investment from Silicon Valley "Super-Angel" 2Singapore Technology Incubator Receives Investment from Silicon Valley "Super-Angel" 3Singapore Technology Incubator Receives Investment from Silicon Valley "Super-Angel" 4Singapore Technology Incubator Receives Investment from Silicon Valley "Super-Angel" 5Singapore Technology Incubator Receives Investment from Silicon Valley "Super-Angel" 6New UC sensor promises rapid detection of dangerous heavy metal levels in humans 2New UC sensor promises rapid detection of dangerous heavy metal levels in humans 3New edition of Manual of Clinical Microbiology offers digital access 2
(Date:10/19/2014)... 19, 2014 The Asia-Pacific Bromine ... in Asia-Pacific with analysis and forecast of revenue. ... Pacific Bromine Market report, to get an idea ... a glimpse of the segmentation in the Asia-Pacific ... and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The Asian arthroscopic devices report defines and ... forecast of revenue. The arthroscopic devices market in Asia ... at a CAGR of 6.5% from 2013 to 2018. ... devices market, to get an idea of the in-depth ... segmentation of arthroscopic devices market in the same region, ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 According to ... Resource & Well Type - Global Trends & Forecasts ... estimated $31 billion in 2011. This value is expected ... billion by 2017, with 10% CAGR during the same ... hydraulic fracturing production market in terms of hydraulic horse ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 2Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 3Hydraulic Fracturing Market Projected To Reach $64 Billion by 2017 - New Report by MarketsandMarkets 4
... Corporation,(Nasdaq: NEOG ) announced today that its revenues ... 31, increased 26% from the previous year,s first,quarter to ... year,s $3,011,000 to $3,733,000, or to $0.25 per share ... Neogen,s first quarter revenues, net income, and earnings ...
... for antibody therapeutics, BASEL, Switzerland, Sept. 24 ... has completed the acquisition of 100% of the ... (TSX: ARI). On,September 19th, the Ontario Superior Court, ... the security holders and announced in a,press release ...
... Journal to Honor http://www.animetrics.com/ [Animetrics] at "Top 100 Private ... ... September 24, 2008 -- Animetrics® Inc., a leading developer of 3D ... named one New Hampshire,s 10 private companies to watch by Business ...
Cached Biology Technology:Neogen Reports 26% Increase in Revenues 2Neogen Reports 26% Increase in Revenues 3Neogen Reports 26% Increase in Revenues 4Neogen Reports 26% Increase in Revenues 5Neogen Reports 26% Increase in Revenues 6Roche completes acquisition of ARIUS 2Animetrics Inc. Named One of Business NH Magazine's '10 Companies to Watch' for its Significant Revenue Growth 2
Anti-Goat HRP-DAB Cell & Tissue Staining Kit...
... The Light Diagnostics Cytomegalovirus (CMV) pp65 Antigenemia ... qualitative identification of lower matrix protein pp65 ... Kit Components: ... One bottle containing 220 mL of buffered ...
... The CultureWell cell culture ... for preparing cultured cells for ... uses medical-grade silicone gaskets preassembled ... cell culture plates. The entire ...
nuclear cap binding protein subunit 1, 80kDa, mRNA...
Biology Products: