Navigation Links
McMaster researchers find missing genes may separate coach potato from active cousin
Date:9/5/2011

Hamilton, ON (September 05, 2011) You may think your lack of resolve to get off the couch to exercise is because you're lazy, but McMaster University researchers have discovered it may be you are missing key genes.

The researchers made their unexpected finding while working with healthy, specially-bred mice, some of which had two genes in muscle essential for exercise removed. The genes control the protein AMP-activated protein kinase (AMPK), an enzyme that is switched on when you exercise.

"Mice love to run," said Gregory Steinberg, associate professor of medicine in the Michael G. DeGroote School of Medicine and Canada Research Chair in Metabolism and Obesity.

"While the normal mice could run for miles, those without the genes in their muscle could only run the same distance as down the hall and back. It was remarkable. The mice looked identical to their brothers or sisters but within seconds we knew which ones had the genes and which one didn't."

The researchers found the mice without the muscle AMPK genes had lower levels of mitochondria and an impaired ability for their muscles to take up glucose while they exercise.

"When you exercise you get more mitochondria growing in your muscle. If you don't exercise, the number of mitochondria goes down. By removing these genes we identified the key regulator of the mitochondria is the enzyme AMPK," said Steinberg.

Thousands of scientists around the world are working on AMPK but the McMaster team is the first to demonstrate its essential role in exercise. Their research appears in the current issue of the Proceedings of the National Academy of Sciences.

Steinberg said the findings are important for individuals who find it difficult to exercise, such as the obese, asthmatics and people in wheelchairs. Their inability to exercise may lead to other complications such as diabetes and heart disease.

The study, he thinks, has a message for
'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Exercise boosts health by influencing stem cells to become bone, not fat, McMaster researchers find
2. McMaster scientists turn skin into blood
3. McMaster, NVIDIA establish first CUDA Teaching Centre in Canada
4. McMaster study unveils lifeline for antibiotic of last resort
5. New research network at McMaster aims to build a better eye
6. McMaster researchers discover new mode of how diseases evolve
7. New mutations in leukemia: Researchers found mechanism that can help design future therapies
8. Yale researchers solve mystery of disappearing bird digit
9. Researchers explain how railways within cells are built in order to transport essential cargos
10. Louisiana Tech University researchers, NASA partner to conduct zero-gravity experiments
11. Breast cancer risk drops when diet includes walnuts, Marshall researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... on September 13, 2014. The fire is human-caused and ... 2,300 acres in size and is mostly being fueled ... calm Monday night due to higher humidity. Yesterday ... beginning to construct a fireline on the West and North ... on the fire: , 7 20-person Crews, 4 Hot Shot ...
(Date:9/16/2014)... viruses that make us sick can take up residence ... sneeze, cough or other troublesome symptom, according to new ... Louis. , On average, healthy individuals carry about ... report online in BioMed Central Biology . The ... diversity of viruses in healthy people. , The ...
(Date:9/16/2014)... doom for the dinosaurs 66 million years ago decimated ... greater extent than their deciduous peers, according to a ... in the journal PLOS Biology . , ... of fossilized leaves of angiosperms flowering plants ... the ecology of a diverse plant community thriving during ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4
... researchers, Eric Hoffman, PhD, of Childrens Research Institute ... relatively short order, medicines next innovation--individualized molecular therapies--will ... dystrophies, and other disorders. In the ... Medicine, Dr. Hoffman posits that the results of ...
... living in the United States are suffering from some ... in Africa, Asia, and Latin America, says the Editor-in-Chief ... entitled Poverty and Neglected Diseases in the Other America, ... Vaccine Institute) says that there is evidence that the ...
... examined, Hispanic women were found to have the highest prevalence ... Asian Americans having the lowest prevalence (0.5 percent), according to ... Mutations in the tumor suppressor gene BRCA1 confer high ... age 70 years has been estimated at 65 percent for ...
Cached Biology News:New clinical trial results show how personalized medicine will alter treatment of genetic disorders 2Poor Americans in the United States suffer hidden burden of parasitic and other neglected diseases 2Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 2Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer 3
(Date:9/17/2014)... Escape Alert, LLC . filed international patents for an ... if their pet has escaped and enable them to track their ... pet’s body. This is the first implantable microchip with GPS. ... for many years, they are passive until read by scanners, do ... location or alert the owner that the pet has escaped. ...
(Date:9/17/2014)... NASA’s MESSENGER has just celebrated its 10 year ... have one of its latch valves, V27200-818, operating onboard ... investigation of the planet Mercury. It is only the ... provided a vast amount of information and images of ... utilize solenoids that also include permanent magnets to maintain ...
(Date:9/17/2014)... The Alliance for Clinical Research ... collaborative building a global system to enhance safety, ... Phase 3 of its Site Accreditation and Standards ... Kalali, Vice-President, Global Head, Neuroscience Center of Excellence ... Quality Integration (CQI) Consulting will lead the effort ...
(Date:9/16/2014)... 2014 This report analyzes the worldwide markets for ... Hardware, and Biocontent. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
Breaking Biology Technology:Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 2Implantable Microchip for Pets with GPS Tracking - Patent Filed by Escape Alert, LLC. 3Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23
... ... costs by partnering with a highly specialized medical tubing manufacturer , ... (PRWEB) March 10, 2010 -- There’s a ... medical tubing supplier. Unless certain steps are taken to ensure that designs and ...
... husband and wife research team has found a way to ... injuries faster and more simply than current methods. And they,ve ... car wreck, bomb blast or disease leaves too little cover. ... and mechanical & aerospace engineering at Case Western Reserve University, ...
... ... ... ... ...
Cached Biology Technology:Medical Device Designers Avoid the Pitfalls of Outsourcing Medical Tubing 2Medical Device Designers Avoid the Pitfalls of Outsourcing Medical Tubing 3Cleveland researchers use natural and artificial sheaths to mend traumatic bone loss 2Cleveland researchers use natural and artificial sheaths to mend traumatic bone loss 3Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 2Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 3Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 4Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 5Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 6Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 7Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 8Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 9Abbott Enhances Pharmaceutical Pipeline with Acquisition of Facet Biotech 10
... The Label IT siRNA Tracker Intracellular ... to directly label and deliver siRNA, of ... manner, for in vitro tracking experiments. Subcellular ... expression can be monitored following introduction of ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
... through the extracellular matrix (ECM) is an ... cells initiate invasion by adhering to and ... Proteolytic enzymes, such as MMP collagenases, dissolve ... membrane) surrounding the blood vessels to allow ...
... Cell Invasion Assay is designed to determine ... as a significant barrier to invasion or ... in a convenient, high-throughput, 96-well format. The ... all types of adherent cells such as ...
Biology Products: