Navigation Links
McMaster researchers discover new mode of how diseases evolve
Date:2/16/2009

Hamilton, ON (February 13, 2009) - Researchers of the Michael G. DeGroote Institute for Infectious Disease Research have discovered a new way that bacteria evolve into something that can make you sick.

The finding, published in the Feb. 16 issue of the Proceedings of the National Academy of Sciences, has implications for how scientists identify and assign risk to emerging diseases in the environment.

The researchers found that bacteria can develop into illness-causing pathogens by rewiring regulatory DNA, the genetic material that controls disease-causing genes in a body. Previously, disease evolution was thought to occur mainly through the addition or deletion of genes.

Brian Coombes, an assistant professor in the Department of Biochemistry and Biomedical Sciences, was the lead investigator of the study which involved researchers at McMaster University, the University of Melbourne, Australia and the University of Illinois at Chicago, USA.

"Bacterial cells contain about 5,000 different genes, but only a fraction of them are used at any given time," Coombes said. "The difference between being able to cause disease, or not cause disease, lies in where, when and what genes in this collection are turned on. We've discovered how bacteria evolve to turn on just the right combination of genes in order to cause disease in a host. It's similar to playing a musical instrument you have to play the right keys in the right order to make music."

With infectious diseases on the rise, the McMaster finding has implications on how new pathogens are identified in the environment. Scientists currently monitor the risk of new diseases by assessing the gene content of bacteria found in water, food and animals.

"This opens up significant new challenges for us as we move forward with this idea of assigning risk to new pathogens," Coombes said. "Because now, we know it's not just gene content it is gene content plus regulation of those genes."


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related biology news :

1. McMaster University engineering professor receives Humboldt Research Award
2. Researchers shed new light on connection between brain and loneliness
3. Texas researchers provide emissions data for livestock industry
4. Biodiversity itself begets a species cascade, researchers say
5. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
6. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
7. NSF-funded workshops help young researchers teach science
8. Researchers observe evolution chain reaction
9. Researchers examine role of climate change in disease spread
10. Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
11. Researchers disprove 15-year-old theory about the nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/28/2016)... Jan. 28, 2016 Synaptics (NASDAQ: SYNA ), a ... its second quarter ended December 31, 2015. ... of fiscal 2016 increased 2 percent compared to the comparable quarter ... of fiscal 2016 was $35.0 million, or $0.93 per diluted share. ... income for the first quarter of fiscal 2016 grew 9 percent ...
(Date:1/25/2016)...  Glencoe Software, the world-leading supplier of image data ... provide the data management solution OMERO Plus for the ... Photo - http://photos.prnewswire.com/prnh/20160125/325328LOGO ... Phenotypic analysis measures the characteristics and behavior of ... states such as health and disease, the presence or ...
(Date:1/21/2016)... , January 21, 2016 ... to a new market research report "Emotion Detection and ... Others), Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020", published by MarketsandMarkets, ... expected to reach USD 22.65 Billion by 2020, ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... Clinovo ... free and validated Electronic Data Capture (EDC) system ClinCaptureand its new Contract Research ... West Coast 2016 Conference in San Mateo, California on February 10th and 11th. ...
(Date:2/9/2016)... ... 2016 , ... The American Academy of Thermology (AAT) has announced ... AAT Member Certification Qualification Course for Technicians via a two part webinar on July ... a detailed review of hardware, software, and camera setup/operations, aligns with the in-person member ...
(Date:2/9/2016)... ... February 09, 2016 , ... PharmApprove ... for the National Organization for Rare Disorders (NORD). Dorman will lead PharmApprove efforts ... are heard throughout the drug regulatory review process. , “Adding Diane Dorman is ...
(Date:2/9/2016)... YORK , Feb. 9, 2016 This ... analyzes the current and future prospects of the market ... this report include companies engaged in the manufacture of ... an executive summary with a market snapshot providing the ... scope of this report. This section also provides the ...
Breaking Biology Technology: