Navigation Links
McMaster researchers discover new mode of how diseases evolve
Date:2/16/2009

Hamilton, ON (February 13, 2009) - Researchers of the Michael G. DeGroote Institute for Infectious Disease Research have discovered a new way that bacteria evolve into something that can make you sick.

The finding, published in the Feb. 16 issue of the Proceedings of the National Academy of Sciences, has implications for how scientists identify and assign risk to emerging diseases in the environment.

The researchers found that bacteria can develop into illness-causing pathogens by rewiring regulatory DNA, the genetic material that controls disease-causing genes in a body. Previously, disease evolution was thought to occur mainly through the addition or deletion of genes.

Brian Coombes, an assistant professor in the Department of Biochemistry and Biomedical Sciences, was the lead investigator of the study which involved researchers at McMaster University, the University of Melbourne, Australia and the University of Illinois at Chicago, USA.

"Bacterial cells contain about 5,000 different genes, but only a fraction of them are used at any given time," Coombes said. "The difference between being able to cause disease, or not cause disease, lies in where, when and what genes in this collection are turned on. We've discovered how bacteria evolve to turn on just the right combination of genes in order to cause disease in a host. It's similar to playing a musical instrument you have to play the right keys in the right order to make music."

With infectious diseases on the rise, the McMaster finding has implications on how new pathogens are identified in the environment. Scientists currently monitor the risk of new diseases by assessing the gene content of bacteria found in water, food and animals.

"This opens up significant new challenges for us as we move forward with this idea of assigning risk to new pathogens," Coombes said. "Because now, we know it's not just gene content it is gene content plus regulation of those genes."


'/>"/>

Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University
Source:Eurekalert

Related biology news :

1. McMaster University engineering professor receives Humboldt Research Award
2. Researchers shed new light on connection between brain and loneliness
3. Texas researchers provide emissions data for livestock industry
4. Biodiversity itself begets a species cascade, researchers say
5. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
6. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
7. NSF-funded workshops help young researchers teach science
8. Researchers observe evolution chain reaction
9. Researchers examine role of climate change in disease spread
10. Mayo Clinic researchers suspect a novel gene is causing restless legs syndrome in a large family
11. Researchers disprove 15-year-old theory about the nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Wound Market with the addition of its newest module, US Hemostats & Sealants. ... for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used ...
(Date:10/11/2017)... CA (PRWEB) , ... October 11, 2017 , ... ... upregulate any gene in its endogenous context, enabling overexpression experiments and avoiding the ... system with small RNA guides is transformative for performing systematic gain-of-function studies. ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
Breaking Biology Technology: