Navigation Links
McLean Hospital researchers awarded $1.9 9 million grant for stem cell, blood research
Date:9/29/2010

Belmont, MAResearchers at Harvard-Affiliated McLean Hospital have been awarded a $1.9 million National Institutes of Health Director's Opportunity Award to continue their research into creating human induced pluripotent (iPS) stem cells using a method aimed at eliminating the risk of cancer and other problems associated with other options such as genome-integrating viral methods.

The three-year grant, made possible through the American Recovery and Reinvestment Act of 2009, was awarded to a research team headed by Kwang-Soo Kim, PhD, director of the Molecular Neurobiology Laboratory at McLean, and Robert Lanza at Stem Cell & Regenerative Medicine International (SCRMI), which is a joint venture with Advanced Cell Technology (ACT) of Worcester and CHA Biotech of Korea.

The joint venture involving ACT has been active in researching the use of these protein-induced pluripotent stem cells as a source of universal red blood cells and platelets for transfusion.

"This was really perfect timing for us because this work is a little bit beyond the capability of a single laboratory. It is technically demanding, labor intensive and expensive research," said Kim. "The award will support our continued research into iPS cell use that both avoids the risk of cancer growth and genetic dysfunction and provides a potential source of unlimited blood supply."

In 2009, Kim's team published an important study in the journal Cell Stem Cell, showing the ability to create stem cells out of human skin cells, eliminating the risk of cancer and removing some of the ethical concerns associated with embryonic stem cells. The paper described using proteins rather than genes or viruses to reprogram human skin cells, eliminating the risk of cancers or other abnormalities developing in the reprogrammed cells associated with the use of genes or viruses.

"The technique is hoped to result in the availability of the first clinic-ready human induced iPS cells, which could ultimately result in the development of treatments for a variety of illnesses, including Alzheimer's and Parkinson's," said Kim. "The technique of using a patient's own skin cells also eliminates the problem of immune rejection that is associated with using embryonic stem cells."

The researchers not only want to apply the technology for stem cell therapy but also for disease modeling, a process that would allow for their use in the laboratory to study disease mechanisms and in pharmaceutical companies to screen new medications.

"The ultimate goal is to use them in personalized cell therapy," explained Kim.

At the same time, the grant money will be used to see whether the iPS cells can be turned into blood lineage cells, including platelets. The SCRMI lab, headed by Lanza, has already shown the ability to make blood lineage cells from human embryonic stem cells.

If the same can be done from human iPS cells, it might be able to generate blood cells for certain patients so they can receive transfusions of blood and platelets from themselves, Kim said.

It would eliminate the problem of rejection and would provide blood lineage cells such as platelets that will be extremely useful in potentially life-threatening situations of blood shortages, he said.

A third goal of the research is to seek to make iPS cells from tissues of patients who have the rare universal blood types Rh- and O-, he added. "If we can make an unlimited amount of blood from these iPS cells, the blood could be used universally, particularly in crisis situations such as war," he said.

"Dr. Lanza's team has the world's top expertise in how to differentiate human embryonic stem cells or iPS cells to blood lineage cells," Kim said. "That is why they have combined with my lab, where we have the expertise to generate iPS cells using the protein method."


'/>"/>

Contact: Adriana Bobinchock
abobinchock@partners.org
617-855-2110
McLean Hospital
Source:Eurekalert

Related biology news :

1. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
2. Vitamin C rapidly improves emotional state of acutely hospitalized patients, say LDI researchers
3. Opioid use to relieve pain and suffering at end of life is safe in hospital-at-home setting
4. Researchers at Childrens Hospital Los Angeles find diet-induced obesity accelerates leukemia
5. Memorial Hospital Selects DigitalPersona Pro to Enhance HIPAA Security
6. Texas Childrens Hospital vaccine experts present 4 studies
7. Nude-colored hospital gowns could help doctors better detect hard-to-see symptoms
8. Temple University Hospital and PASNAP Negotiations Break Off: Talks to Resume Later Today
9. Researchers find Clostridium difficile is more common than MRSA in southeast community hospitals
10. Hospital scanner could curb nuclear waste threat
11. University Hospitals Case Medical Center testing gene therapy for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:5/24/2016)... Calif. , May 24, 2016 Ampronix facilitates superior patient care by ... LMD3251MT  3D medical LCD display is the latest premium product recently added to the ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... Raleigh, NC (PRWEB) , ... June 27, 2016 ... ... a mission to bring innovative medical technologies, services and solutions to the healthcare ... development and implementation of various distribution, manufacturing, sales and marketing strategies that are ...
(Date:6/27/2016)...   Ginkgo Bioworks , a leading organism ... today awarded as one of the World Economic ... most innovative companies. Ginkgo Bioworks is engineering biology ... world in the nutrition, health and consumer goods ... customers including Fortune 500 companies to design microbes ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
Breaking Biology Technology: