Navigation Links
McGill/JGH researchers successfully reverse multiple sclerosis in animals
Date:8/11/2009

at the Jewish General and McGill's Centre for Translational Research. "GIFT15 is a new protein hormone composed of two distinct proteins, and when they're stuck together they lead to a completely unexpected biological effect."

This effect, explained Galipeau, converts B-cells -- a common form of white blood cell normally involved in immune response -- into powerful immune-suppressive cells. Unlike their better-known cousins, T-cells, naturally-occurring immune-suppressing B-cells are almost unknown in nature and the notion of using them to control immunity is very new.

"GIFT15 can take your normal, run-of-the-mill B-cells and convert them -- in a Superman or Jekyll -Hyde sort of way -- into these super-powerful B-regulatory cells," Galipeau explained. "We can do that in a petri dish. We took normal B-cells from mice, and sprinkled GIFT15 on them, which led to this Jekyll and Hyde effect.

"And when we gave them back intravenously to mice ill with multiple sclerosis, the disease went away."

MS must be caught in its earliest stages, Galipeau cautioned, and clinical studies are needed to test the treatment's efficacy and safety in humans. No significant side-effects showed up in the mice, he said, and the treatment was fully effective with a single dose.

"It's easy to collect B-cells from a patient," he added. "It's just like donating blood. We purify them in the lab, treat them with GIFT15 in a petri dish, and give them back to the patient. That's what we did in mice, and that's what we believe we could do in people. It would be very easy to take the next step, it's just a question of finding the financial resources and partnerships to make this a reality."


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
2. Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding
3. University of Hawaii at Manoa researchers reveal ocean acidification at Station ALOHA
4. UBC researchers find first-ever wanderlust gene in tiny bony fish
5. Pitt researchers find promising candidate protein for cancer prevention vaccines
6. K-State researchers say after-school programs should promote activity, healthy nutrition
7. MU researchers create drought conditions to unearth solutions
8. Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers
9. UCSF researchers identify new drug target for Kaposis sarcoma
10. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
11. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
McGill/JGH researchers successfully  reverse multiple sclerosis in animals
(Date:3/2/2015)... VILNIUS, Lithuania , March 2, 2015   ... AI technologies, today introduced the SentiGaze Software Development ... developers to create applications that use off-the-shelf webcams to ... a user gazes at a monitor. Heatmaps can be ... determining the effectiveness of online advertising. The SDK can ...
(Date:2/23/2015)... , Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62114357 for DISTRIBUTED VOICE DIRECTED ... NXT-ID introduces a new groundbreaking payment method. Payment accounts ... account may only be accessed if both the speech ...
(Date:2/12/2015)... 12, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... 62/113114 for DISTRIBUTED METHOD AND SYSTEM TO ... patent further establishes NXT-ID,s position in the emerging "Internet ... the ability for multiple devices to collaborate with one ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3
... have reconstructed the past six thousand years in estuary ... algae abundance. Their findings, published in Global Change ... seagrass in the past 60 years. This shift could ... carbon sinks, to mitigate climate change. According to ...
... Warmer, drier summers and extreme weather events considered possible ... possibly fatal - for walnut trees, according to research ... a professor of forestry and natural resources, and Martin-Michel ... now a research scientist in the Ministry of Natural ...
... food system is needed to address future threats to ... world,s leading science organisations. ,The Commission on Sustainable ... commission of eminent scientists has released a blueprint ... of feeding the world in the face of climate ...
Cached Biology News:Walnut trees may not be able to withstand climate change 2Australian science joins global effort to transform food system 2Australian science joins global effort to transform food system 3
(Date:3/4/2015)... 04, 2015 USDM Life Sciences ... life sciences industry, hired David Blewitt as ... Cloud Compliance Services and Solutions at USDM Life Sciences ... applications while maintaining compliance with government regulations worldwide. ... an accomplished life sciences regulatory and IS compliance professional ...
(Date:3/4/2015)... 2015 /CNW/ - Resverlogix Corp. (TSX:RVX) (the "Company") ... collaborative research program with Emerald Logic, a ... Evolution Technology (FACET), Emerald Logic analyzed Resverlogix,s ... from each of 798 patients who participated ... ASSERT, SUSTAIN and ASSURE. The objective of ...
(Date:3/4/2015)... 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ... on the development and commercialization of innovative therapies ... today announced that it will release fourth quarter ... on Monday, March 9th, 2015. AcelRx management will ... Eastern Time (1:30 p.m. Pacific Time) on March ...
(Date:3/4/2015)... Jose, California (PRWEB) March 04, 2015 ... Reaction (PCR) represents one of the fastest growing technologies ... cell biologists in subcellular visualization is driving growth in ... need for deeper understanding of gene expressions will continue ... market. Expanding applications in fields ranging from pharma, biotech, ...
Breaking Biology Technology:USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 2Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 3Resverlogix Collaborates with Emerald Logic to Identify Factors Driving Drug Response and Efficacy in Phase 2 Program 4AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4
... Pfizer R&D Head Martin,Mackay, HHS Deputy Secretary Tevi Troy, ... at FDA/CMS Summit 2007, WASHINGTON, Nov. 15 ... approvals. Unfortunately for the biopharma sector and,investors, it,s a ... track,to grant marketing approval to 18 or fewer new ...
... publisher of the,journal STEM CELLS(R), has named Donald ... I. Civin, current STEM CELLS Editor, retires after ... journal,s most significant metrics:,Impact Factor, number of pages ... as editor-in-chief, Dr. Civin was assisted by,three outgoing ...
... Units to Focus on Convergence and New Opportunities, ... announced a series of organizational changes to sharpen its,focus ... in the,growing intersections of health care. These include the ... new business operating groups. The,changes are designed to accelerate ...
Cached Biology Technology:So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 2So Long, Old Friend: The End of the Blockbuster Drug Era? What 2008 Holds for Bringing Drugs to Market 3STEM CELLS Journal Names Co-Editors 2Johnson & Johnson Announces Changes to Accelerate Growth 2Johnson & Johnson Announces Changes to Accelerate Growth 3
Request Info...
...
... High Resolution - Efficiently ... 50 to 1000 bp. ... sizing PCR fragments, small ... restriction enzyme digestion, and ...
... Clone/PAD: ZMD.358. Immunogen: Synthetic ... region of human mouse and ... with human and mouse LRP5 ... (positive controls: mouse LRP5-pSEC-tag-transfected 293T ...
Biology Products: