Navigation Links
Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth
Date:11/17/2008

mor suppressor when it is bound to E-cadherin, and like a tumor promoter when it isn't," Dr. Anastasiadis says.

The researchers believe these findings could help explain why in some solid tumors, such as breast, lung, kidney, and melanoma, loss of E-cadherin is associated with a more aggressive, less treatable prognosis. "We think that when E-cadherin is lost, p120 is now free to turn on growth promotion pathways that can overtake the benefits of targeted chemotherapeutics," he says.

"So in breast cancer that is HER2-positive, anti-HER2 therapies such as Herceptin will not function well if p120 has turned on alternate growth mechanisms," Dr. Anastasiadis says. "A similar effect would also be expected in EGFR-positive lung cancer and anti-EGFR treatment." Both HER2 and EGFR are growth-promotion proteins.

A potential solution would be to design an agent that targets the tumor-promoting function of p120 that is not bound to E-cadherin, he says. "This won't be easy, but based on our current understanding of p120 function we believe it is possible," says Dr. Anastasiadis.


'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... , May 18, 2015 Fingerprint Cards ... FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if its ... until and including Q3 2015 and the sensors will be ... Communicated order values for 2015 hereby amount to 740 MSEK ... 2015 of 140 MSEK and a number of smaller orders ...
(Date:5/14/2015)... NEW YORK , May 14, 2015 ... specializing in identity verification and online remote ... Instructure, a software-as-a-service (SaaS) company and creator ... Shared customers of the two companies will ... Proctortrack in Canvas. As a ...
(Date:5/8/2015)... SAN JOSE, Calif. , May 8, 2015 ... human interface solutions, today announced that members of the executive ... J.P. Morgan 43rd Annual Technology, Media and Telecom Conference ... Westin Waterfront Hotel in Boston, MA ... Date: May 27, 2015 Time: 2:45pm ET Location: The New ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2
... Using underwater speakers to play noise at levels ... found that three-spined sticklebacks exposed to even brief noise ... at consuming the available food compared to those in ... author, said: "The fish appeared to be distracted by ...
... gut may not just be helping digest food but also ... functions of other organs, like the liver, according to research ... These findings offer new understanding of the symbiotic relationship between ... microbiota can impact overall health. "The gut microbiota enhances ...
... Elizabeth Canuel of the Virginia Institute of Marine ... U.S., Canada, and Mexico who have been awarded ... As a Leopold Fellow, Canuel will participate ... around Capitol Hilldesigned to promote effective communication of ...
Cached Biology News:Noise distracts fish from their dinner 2Gut bacteria can control organ functions 2VIMS professor selected as Leopold Fellow 2VIMS professor selected as Leopold Fellow 3
(Date:5/29/2015)...  Caris Life Sciences ® , a leading ... precision medicine, today announced the presentation of data ... of Caris Molecular Intelligence ® , the company,s ... identify targeted treatment options for patients with rare ... results of which are to be presented in ...
(Date:5/29/2015)... Seoul Semiconductor (CEO: Chung-hoon Lee, http://www.seoulsemicon.com ... 28th announced that it will increase the global ... efficient and high reliable LED product line-up for ... has developed efficient and reliable LED packages for ... for headlamps to global auto makers. Seoul Semiconductor’s ...
(Date:5/28/2015)... N.J. , May 28, 2015  Quest Diagnostics ... of diagnostic information services, announced that it is scheduled ... in New York.  Steve Rusckowski , the company,s ... and five point strategy.  The presentation is scheduled for ... The presentation will be webcast live during ...
(Date:5/28/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/6cg3zw/cell_therapy ) has announced ... "Cell Therapy - Technologies, Markets and Companies" ... and evaluates cell therapy technologies and methods, which ... in the practice of medicine. Hematopoietic stem cell ... transplants. Role of cells in drug discovery is ...
Breaking Biology Technology:Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6Seoul Semiconductor Increases the Global Automotive LED Market Share with its High Efficient and Reliable LEDs for Automotive Lightings 2Quest Diagnostics to Speak at the Jefferies 2015 Global Healthcare Conference 2Global Cell Therapy Market 2015-2020 - Technologies, Markets and Companies 2
... LAFAYETTE, Ind. - Purdue University scientists have developed a ... a biosensor electrode, a development that may lead to ... other diseases. Standard sensors employ metal electrodes coated ... electrical signal that can be measured. But the inefficiency ...
... ANGELES, Nov. 15, 2011 There is an old rhetorical ... one hears it, does it make a sound?" That same ... Morgellons disease . The medical community at large still dismisses ... these people,s suffering is being ignored doesn,t make their tragedy ...
... 2011 Quest Diagnostics Incorporated (NYSE: DGX ... and services, today announced that its Focus Diagnostics business ... test kit on the 3M™ Integrated Cycler for distribution ... designed to enable hospital labs to perform advanced molecular ...
Cached Biology Technology:New biosensor benefits from melding of carbon nanotubes, DNA 2The Foremost Expert on Morgellons Disease Highlights the Gravity of This Illness 2Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 2Quest Diagnostics CE Marks Simplexa™ Test for Cytomegalovirus for Sale in Europe 3
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Protein 3D structure prediction, via threading. Easy to use....
... Blot Processing Standard Tray (3 per ... gel staining and blot processing.Automated staining ... for proteins and nucleic acid analysis.Prepares ... and chromogenic detection.Programmable control of protocol, ...
DITHIOTHREITOL, 150UMOL, 1 EA. Dithiothreitol (DTT), 0.1 M Solution:, *0.1 M solution of DTT in high purity dH2O., *0.2 m filtered., *Storage: -20C. Category: SEQUENASE....
Biology Products: