Navigation Links
Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth
Date:11/17/2008

latest work.

P120 acts in cells by regulating the function of proteins called cadherins. Cadherins are membrane proteins that help cells stick to each other to form a tissue. On the outside of a cell's membrane, they act like Velcro, fusing to other cadherin proteins on adjacent cells. On the inside, they latch on to a chainwork of catenins, which are proteins that regulate a cell's shape and function. The best understood of the cadherins is E-cadherin, which binds all epithelial cells to each other, forming layers that cover the inside of organs and body cavities, and the outside skin of humans. In short, E-cadherin holds a human's cells and tissues together, Dr. Anastasiadis says.

P120 normally binds onto E-cadherin, strengthening cell-cell bonding. But in some cases it detaches from E-cadherin, which allows the cell to lose its adhesive grip to adjacent cells and switch on a program that promotes cell movement. The loss of E-cadherin expression during a process known as epithelial-mesenchymal transition (EMT) is one mechanism of activating p120's pro-migratory function, the researchers say. EMT is necessary during human development, or during wound healing in adults. But it is a process that is hijacked by tumors to allow cancer cells to migrate and colonize other organs. "When E-cadherin production is lost during the progression of cancer, p120 catenin induces invasion and metastasis," Dr. Anastasiadis says.

In this study, the researchers discovered that not only does p120 promote metastasis when it is not bound to E-cadherin, it also turns on growth-promoting genes and proteins. In laboratory and animal experiments, they found that "free" p120 makes cancer very aggressive, able to grow in conditions that other cancer cells can't. They specifically found that p120 activates a family of molecules that includes Ras and Rho, which promote cell growth and movement.

"What is really interesting here is that p120 is acting like a tu
'/>"/>

Contact: Paul Scotti
scotti.paul@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Fish can live in almost any aquatic environment on ... up many species are pushed to the limit. The ... could prove critical for how different species cope in ... the University of Gothenburg, published in the scientific journal ... Climate change continues apace thanks to increasing levels of ...
(Date:9/30/2014)... it comes to using marijuana, new research, involving mice ... Journal of Leukocyte Biology , suggests ... that you should. That,s because a team of Italian ... do serious long-term damage to the immune system. This ... diseases, such as multiple sclerosis, inflammatory bowel disease and ...
(Date:9/30/2014)... trouble getting pregnanteven with IVF? Here,s some hope: A ... The FASEB Journal , explains how ... known as PAWP, which induced embryo development in human ... embryo development by the sperm cell during fertilization. , ... a major paradigm shift in our understanding of human ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... and terrorist attacks may bring about profound spiritual ... for people that have experienced or witnessed these ... mental disorder caused by psychological trauma is termed ... damage alter as symptoms improve? As PTSD progresses, ...
... just published research that will help you every morning ... Vice-Chancellor will allow oceanographers and meteorologists to better predict ... as they travel across the globe. "Ocean cargo ... activities such as surfing, are all dependent on wave ...
... recently awarded a $449,641 grant by the Institute of Museum ... crowd sourcing and gaming to support the enhancement of texts ... December 2013 and ends in December 2015. The Garden will ... Botanical Garden on the project. , The BHL is ...
Cached Biology News:VC predicts the motion of the ocean 2Missouri Botanical Garden aims to improve access to digital texts through online gaming 2
(Date:9/30/2014)... Nematicide is a type of chemical ... parasitic roundworms, found in massive quantities virtually everywhere—in ... animals. Nematicides have tended to be broad-spectrum toxicants ... through the soil. A single gram of soil ... more than 10,000 species classified, they are one ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market is ... increased acceptance of new filtration technologies in end users ... also catalyzing the growth of laboratory filtration market. , ... at a strong CAGR during the forecast period of ... by 2019. The market is mainly driven by the ...
(Date:9/30/2014)... 30, 2014 Proove Biosciences , ... excited to announce a new genetic test built upon ... Pain Perception Test will provide physicians with an ... pain tolerance levels are stratified between individuals. With this ... a person has a genetic predisposition that will affect ...
(Date:9/30/2014)... Jose, California (PRWEB) September 30, 2014 ... measure the level of each type of cholesterol carrier ... since the presence of excessive cholesterol levels in the ... a precursor condition to heart attack and other cardiovascular ... fatality worldwide, therefore testing for cholesterol levels on a ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... ), focused on discovering, developing and,commercializing treatments for diabetes and ... -- 18th Annual Wachovia Nantucket Equity Conference on Monday, ... (Eastern Time) at The White Elephant in Nantucket ... Conference on Thursday, June 26, 2008 ...
... and Advance,Healthcare, WASHINGTON, June 16 The ... Act (HIPAA) is having a,negative impact on the ... that benefit society, says a newly-released report by ... Barriers to,Research and Discovery describes the unintended disruptive ...
... ROCKVILLE, Md., June 16 Novavax, Inc.,(Nasdaq: NVAX ... Singhvi, President and Chief Executive Officer, will be presenting ... on June 24, 2008 at,The ANdAZ Hotel in London, ... strategy, research and development progress. A link to the ...
Cached Biology Technology:HIPAA Privacy Rule Impedes Biomedical Research 2
100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
...
Tube-O-DIALYZER Floats, small....
Biology Products: